No phenotype data for mouse, yeast is essential ORTHOMCL1388: YPR165W, ENSP00000265538 YPR165W RHO1: GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) MGI:1096342 No phenotype data for mouse, yeast is nonessential ORTHOMCL4649: YMR193W, ENSP00000199706 YMR193W MRPL24: Mitochondrial ribosomal protein of the large subunit MGI:1915861 No phenotype data for mouse, yeast is essential ORTHOMCL4902: YNR035C, ENSP00000327137 YNR035C ARC35: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin MGI:1923959 No phenotype data for mouse, yeast is essential ORTHOMCL4043: YOR232W, ENSP00000264954 YOR232W MGE1: Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpE MGI:1334417 No phenotype data for mouse, yeast is nonessential ORTHOMCL863: YKL025C, ENSP00000282391 YKL025C PAN3: Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes MGI:1919837 No phenotype data for mouse, yeast is nonessential ORTHOMCL3283: YGL070C, ENSP00000221859 YGL070C RPB9: RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenance MGI:1917170 No phenotype data for mouse, yeast is essential ORTHOMCL3995: YDL111C, ENSP00000265564 YDL111C RRP42: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p MGI:1913696 Mouse only essential ORTHOMCL12009: YEL009C, ENSP00000252818 YEL009C GCN4: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels MGI:96648 Jund1: Jun proto-oncogene related gene d1 No phenotype data for mouse, yeast is nonessential ORTHOMCL4591: YDR329C, ENSP00000036971 YDR329C PEX3: Peroxisomal membrane protein (PMP) required to recruit Pex19p chaperone to peroxisomes; plays selective, essential, direct role in PMP import as a docking factor for Pex19p MGI:1929646 No phenotype data for mouse, yeast is essential ORTHOMCL3142: YMR197C, ENSP00000281221 YMR197C VTI1: Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways MGI:1855699 Neither essential ORTHOMCL6522: YDR305C, ENSP00000342087 YDR305C HNT2: Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins MGI:1277947 Fhit: fragile histidine triad gene No phenotype data for mouse, yeast is nonessential ORTHOMCL2849: YNL071W, ENSP00000280346 YNL071W LAT1: Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA MGI:2385311 No phenotype data for mouse, yeast is nonessential ORTHOMCL5451: YDL116W, ENSP00000229179 YDL116W NUP84: Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesis MGI:2143854 No phenotype data for mouse, yeast is nonessential ORTHOMCL5230: YHR051W, ENSP00000317780 YHR051W COX6: Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels MGI:88474 No systematic deletion data for yeast, no mouse data ORTHOMCL396: YHR119W, ENSP00000267197 YHR119W MGI:2652820 No phenotype data for mouse, yeast is essential ORTHOMCL3770: YIL143C, ENSP00000285398 YIL143C SSL2: Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3 MGI:95414 Both essential ORTHOMCL4169: YDR167W, ENSP00000299424 YDR167W TAF10: Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification MGI:1346320 Taf10: TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor No phenotype data for mouse, yeast is essential ORTHOMCL4053: YPR187W, ENSP00000215960 YPR187W RPO26: RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit MGI:1349393 No phenotype data for mouse, yeast is essential ORTHOMCL4086: YPR086W, ENSP00000260511 YPR086W SUA7: Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II MGI:2385191 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000089750 ORTHOMCL16368: YBR271W, ENSP00000300209 YBR271W : Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR271W is not as essential gene No phenotype data for mouse, yeast is nonessential ORTHOMCL6262: YBR279W, ENSP00000221265 YBR279W PAF1: RNA polymerase II-associated protein, defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genes MGI:1923988 No phenotype data for mouse, yeast is nonessential ORTHOMCL6688: YDR004W, ENSP00000343392 YDR004W RAD57: Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p MGI:1921585 No phenotype data for mouse, yeast is nonessential ORTHOMCL12651: YPL206C, ENSP00000284116 YPL206C : Protein that plays a role in metabolism of glycerophosphocholine to phosphatidylcholine; contains glycerophosphodiester phosphodiesterase motifs MGI:1913819 No phenotype data for mouse, yeast is essential ORTHOMCL4373: YNR043W, ENSP00000301012 YNR043W MVD1: Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer MGI:2179327 No phenotype data for mouse, yeast is essential ORTHOMCL3346: YNL232W, ENSP00000306711 YNL232W CSL4: Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradation MGI:1913833 Mouse only essential ORTHOMCL3954: YCL008C, ENSP00000251968 YCL008C STP22: Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype MGI:106581 Tsg101: tumor susceptibility gene 101 No phenotype data for mouse, yeast is essential ORTHOMCL4691: YPR016C, ENSP00000246231 YPR016C TIF6: Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits MGI:1196288 No phenotype data for mouse, yeast is essential ORTHOMCL2236: YMR296C, ENSP00000262554 YMR296C LCB1: Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine MGI:1099431 No phenotype data for mouse, yeast is essential ORTHOMCL3713: YNL178W, ENSP00000278572 YNL178W RPS3: Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins MGI:1350917 No phenotype data for mouse, yeast is nonessential ORTHOMCL8692: YHR116W, ENSP00000347469 YHR116W COX23: Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p MGI:1913683 Mouse only essential ORTHOMCL5327: YMR080C, ENSP00000262803 YMR080C NAM7: ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance MGI:107995 Upf1: UPF1 regulator of nonsense transcripts homolog (yeast) No phenotype data for mouse, yeast is nonessential ORTHOMCL5167: YBL082C, ENSP00000311641 YBL082C ALG3: Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins MGI:1098592 No phenotype data for mouse, yeast is nonessential ORTHOMCL4455: YKL100C, ENSP00000262657 YKL100C : Hypothetical protein MGI:95886 No phenotype data for mouse, yeast is nonessential ORTHOMCL3130: YBR222C, ENSP00000320646 YBR222C PCS60: Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase MGI:2182591 No phenotype data for mouse, yeast is nonessential ORTHOMCL3517: YOR323C, ENSP00000265984 YOR323C PRO2: Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis MGI:1888908 No phenotype data for mouse, yeast is essential ORTHOMCL6056: YER146W, ENSP00000223084 YER146W LSM5: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA MGI:1913623 No phenotype data for mouse, yeast is essential ORTHOMCL6186: YLR127C, ENSP00000314004 YLR127C APC2: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53p MGI:2139135 No phenotype data for mouse, yeast is essential ORTHOMCL2707: YPR110C, ENSP00000304153 YPR110C RPC40: RNA polymerase subunit, common to RNA polymerase I and III MGI:103288 No phenotype data for mouse, yeast is essential ORTHOMCL4661: YGR047C, ENSP00000263956 YGR047C TFC4: One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 MGI:2138383 No phenotype data for mouse, yeast is essential ORTHOMCL4244: YMR049C, ENSP00000304151 YMR049C ERB1: Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1 MGI:1334460 No phenotype data for mouse, yeast is nonessential ORTHOMCL4400: YER151C, ENSP00000219473 YER151C UBP3: Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin MGI:894652 No phenotype data for mouse, yeast is nonessential ORTHOMCL2572: YMR292W, ENSP00000229314 YMR292W GOT1: Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2p MGI:1914214 No phenotype data for mouse, yeast is essential ORTHOMCL4908: YPR190C, ENSP00000334564 YPR190C RPC82: RNA polymerase III subunit C82 MGI:1921664 No phenotype data for mouse, yeast is nonessential ORTHOMCL4651: YOR115C, ENSP00000330289 YOR115C TRS33: One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic MGI:1925482 No phenotype data for mouse, yeast is essential ORTHOMCL8033: YHR019C, ENSP00000256854 YHR019C DED81: Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA MGI:1917473 No phenotype data for mouse, yeast is nonessential ORTHOMCL3399: YKL033W-A, ENSP00000252304 YKL033W-A : Putative protein of unknown function; similar to uncharacterized proteins from other fungi MGI:1914615 No phenotype data for mouse, yeast is nonessential ORTHOMCL638: YLL019C, ENSP00000347759 YLL019C KNS1: Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues MGI:1098669 No phenotype data for mouse, yeast is nonessential ORTHOMCL7081: YLR417W, ENSP00000258599 YLR417W VPS36: Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome MGI:1917410 No phenotype data for mouse, yeast is nonessential ORTHOMCL4644: YGR220C, ENSP00000264995 YGR220C MRPL9: Mitochondrial ribosomal protein of the large subunit MGI:2137204 No phenotype data for mouse, yeast is nonessential ORTHOMCL2435: YAL014C, ENSP00000305255 YAL014C SYN8: Endosomal SNARE related to mammalian syntaxin 8 MGI:1890156 No phenotype data for mouse, yeast is nonessential ORTHOMCL6059: YJR055W, ENSP00000225410 YJR055W HIT1: Protein of unknown function, required for growth at high temperature MGI:3051596 No phenotype data for mouse, yeast is essential ORTHOMCL2417: YKL195W, ENSP00000295767 YKL195W MIA40: Essential protein of the mitochondrial intermembrane space, involved in import and assembly of intermembrane space proteins MGI:1919420 No phenotype data for mouse, yeast is nonessential ORTHOMCL3470: YGR031W, ENSP00000222800 YGR031W : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion MGI:1916008 No phenotype data for mouse, yeast is nonessential ORTHOMCL9701: YPR026W, ENSP00000309110 YPR026W ATH1: Acid trehalase required for utilization of extracellular trehalose MGI:2444047 No phenotype data for mouse, yeast is essential ORTHOMCL3198: YPR088C, ENSP00000216774 YPR088C SRP54: Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain MGI:1346087 Mouse only essential ORTHOMCL5136: YMR274C, ENSP00000309163 YMR274C RCE1: Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone MGI:1336895 Rce1: RCE1 homolog, prenyl protein peptidase (S. cerevisiae) No phenotype data for mouse, yeast is essential ORTHOMCL3913: YJR013W, ENSP00000271552 YJR013W GPI14: Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M MGI:1914806 Mouse only essential ORTHOMCL6240: YER107C, ENSP00000217117 YER107C GLE2: Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p MGI:1913929 Rae1: RAE1 RNA export 1 homolog (S. pombe) No phenotype data for mouse, yeast is essential ORTHOMCL1629: YKL024C, ENSP00000294340 YKL024C URA6: Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) MGI:1913838 No phenotype data for mouse, yeast is nonessential ORTHOMCL3100: YLR377C, ENSP00000253266 YLR377C FBP1: Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism MGI:95492 No phenotype data for mouse, yeast is essential ORTHOMCL2921: YDR088C, ENSP00000297151 YDR088C SLU7: RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain MGI:2385598 No phenotype data for mouse, yeast is essential ORTHOMCL10525: YAR008W, ENSP00000305524 YAR008W SEN34: Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease MGI:1913328 No phenotype data for mouse, yeast is nonessential ORTHOMCL5178: YOR184W, ENSP00000277070 YOR184W SER1: 3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p MGI:2183441 Neither essential ORTHOMCL8565: YER179W, ENSP00000216024 YER179W DMC1: Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein MGI:105393 Dmc1h: disrupted meiotic cDNA 1 homolog No phenotype data for mouse, yeast is essential ORTHOMCL4397: YIR008C, ENSP00000350491 YIR008C PRI1: Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair MGI:97757 No phenotype data for mouse, yeast is essential ORTHOMCL3875: YMR001C, ENSP00000300093 YMR001C CDC5: Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrate MGI:97621 No phenotype data for mouse, yeast is essential ORTHOMCL8311: YOR340C, ENSP00000222567 YOR340C RPA43: RNA polymerase I subunit A43 MGI:106292 No phenotype data for mouse, yeast is nonessential ORTHOMCL2254: YBR187W, ENSP00000257288 YBR187W : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YBR187W is an essential gene MGI:894407 No phenotype data for mouse, yeast is essential ORTHOMCL10326: YNL260C, ENSP00000279147 YNL260C : Protein required for cell viability MGI:1919534 No phenotype data for mouse, yeast is nonessential ORTHOMCL6299: YNL219C, ENSP00000316397 YNL219C ALG9: Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation MGI:1924753 No phenotype data for mouse, yeast is nonessential ORTHOMCL3525: YLR148W, ENSP00000220509 YLR148W PEP3: Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis, forms complex with Pep5p that mediates protein transport to the vacuole MGI:2443626 No phenotype data for mouse, yeast is essential ORTHOMCL5047: YBR055C, ENSP00000266079 YBR055C PRP6: Splicing factor, component of the U4/U6-U5 snRNP complex MGI:1922946 No phenotype data for mouse, yeast is nonessential ORTHOMCL2745: YNL021W, ENSP00000334061 YNL021W HDA1: Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation MGI:1333752 No phenotype data for mouse, yeast is nonessential ORTHOMCL5176: YCR063W, ENSP00000222969 YCR063W BUD31: Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern MGI:2141291 No phenotype data for mouse, yeast is nonessential ORTHOMCL9191: YAL020C, ENSP00000265965 YAL020C ATS1: Protein with a potential role in regulatory interactions between microtubules and the cell cycle, as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1 MGI:1351630 No phenotype data for mouse, yeast is essential ORTHOMCL3555: YFL017C, ENSP00000216410 YFL017C GNA1: Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA MGI:1858963 No phenotype data for mouse, yeast is essential ORTHOMCL5551: YLL011W, ENSP00000297579 YLL011W SOF1: Essential subunit of the U3 (box C+D) snRNP complex required for 2' O-methylation of pre-RNA; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p MGI:2684929 No phenotype data for mouse, yeast is nonessential ORTHOMCL5534: YDL219W, ENSP00000262550 YDL219W DTD1: D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes MGI:1913294 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000032140 ORTHOMCL6925: YJR134C, ENSP00000348582 YJR134C SGM1: Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus No phenotype data for mouse, yeast is essential ORTHOMCL3781: YPR168W, ENSP00000255764 YPR168W NUT2: Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription MGI:106331 No phenotype data for mouse, yeast is nonessential ORTHOMCL4615: YIL064W, ENSP00000351845 YIL064W : Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family MGI:1919346 No phenotype data for mouse, yeast is essential ORTHOMCL2887: YMR146C, ENSP00000197492 YMR146C TIF34: Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translation MGI:1860763 No phenotype data for mouse, yeast is nonessential ORTHOMCL5834: YCR087C-A, ENSP00000345917 YCR087C-A : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene MGI:107470 No phenotype data for mouse, yeast is nonessential ORTHOMCL5235: YPR131C, ENSP00000335636 YPR131C NAT3: Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met MGI:1915127 Yeast only essential ORTHOMCL4152: YDL102W, ENSP00000262266 YDL102W CDC2: Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) MGI:97741 Pold1: polymerase (DNA directed), delta 1, catalytic subunit No phenotype data for mouse, yeast is essential ORTHOMCL6770: YOR004W, ENSP00000308332 YOR004W UTP23: Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function MGI:1925831 No phenotype data for mouse, yeast is essential ORTHOMCL314: YDR328C, ENSP00000231487 YDR328C SKP1: Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase MGI:103575 No phenotype data for mouse, yeast is nonessential ORTHOMCL6110: YGR021W, ENSP00000258975 YGR021W : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion MGI:1917457 No phenotype data for mouse, yeast is nonessential ORTHOMCL6958: YNR030W, ENSP00000333813 YNR030W ALG12: Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation MGI:2385025 No systematic deletion data for yeast, no mouse data ORTHOMCL7758: YBL059C-A, ENSP00000219400 YBL059C-A MGI:1913781 No phenotype data for mouse, yeast is nonessential ORTHOMCL6003: YNR020C, ENSP00000300145 YNR020C : Hypothetical protein MGI:1916984 No phenotype data for mouse, yeast is essential ORTHOMCL13063: YDR164C, ENSP00000221283 YDR164C SEC1: Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function MGI:107370 Both essential ORTHOMCL4378: YDL132W, ENSP00000326804 YDL132W CDC53: Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation MGI:1349658 Cul1: cullin 1 No phenotype data for mouse, yeast is essential ORTHOMCL5625: YOR168W, ENSP00000307567 YOR168W GLN4: Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions MGI:1915851 Neither essential ORTHOMCL6374: YDR283C, ENSP00000263791 YDR283C GCN2: Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex MGI:1353427 Eif2ak4: eukaryotic translation initiation factor 2 alpha kinase 4 No phenotype data for mouse, yeast is nonessential ORTHOMCL2920: YPR147C, ENSP00000237822 YPR147C : Hypothetical protein MGI:1916082 No phenotype data for mouse, yeast is essential ORTHOMCL2308: YGR175C, ENSP00000265896 YGR175C ERG1: Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine MGI:109296 No phenotype data for mouse, yeast is nonessential ORTHOMCL5630: YLR077W, ENSP00000333799 YLR077W FMP25: The authentic, non-tagged protein was localized to the mitochondria MGI:2137600 No phenotype data for mouse, yeast is nonessential ORTHOMCL1270: YNL265C, ENSP00000330408 YNL265C IST1: Putative translation initiation factor, as suggested by computational analysis of large-scale protein-protein interaction data MGI:1919205 No phenotype data for mouse, yeast is essential ORTHOMCL4793: YLR274W, ENSP00000216122 YLR274W CDC46: Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase MGI:103197 Mouse only essential ORTHOMCL6662: YGL043W, ENSP00000353558 YGL043W DST1: General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites MGI:1196624 Tcea1: transcription elongation factor A (SII) 1 No phenotype data for mouse, yeast is essential ORTHOMCL5186: YCL017C, ENSP00000262876 YCL017C NFS1: Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria MGI:1316706 Mouse only essential ORTHOMCL10198: YCR065W, ENSP00000333188 YCR065W HCM1: Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role MGI:1349428 Foxl2: forkhead box L2 No phenotype data for mouse, yeast is essential ORTHOMCL6507: YLR002C, ENSP00000312669 YLR002C NOC3: Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation MGI:1932610 No phenotype data for mouse, yeast is essential ORTHOMCL5110: YFL045C, ENSP00000268261 YFL045C SEC53: Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen MGI:1859214 No phenotype data for mouse, yeast is essential ORTHOMCL3298: YFR005C, ENSP00000312981 YFR005C SAD1: Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle MGI:107622 No phenotype data for mouse, yeast is essential ORTHOMCL4099: YKR038C, ENSP00000206542 YKR038C KAE1: Putative glycoprotease that interacts with Bud32p, which is a member of the novel protein kinase piD261 family MGI:1913496 No phenotype data for mouse, yeast is essential ORTHOMCL4754: YLR022C, ENSP00000246868 YLR022C SDO1: Essential protein involved in RNA metabolism, one of two yeast homologs (with Yhr087wp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in Archaea MGI:1913961 No phenotype data for mouse, yeast is nonessential ORTHOMCL4967: YMR026C, ENSP00000225873 YMR026C PEX12: RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import, forms translocation subcomplex with Pex2p and Pex10p MGI:2144177 No phenotype data for mouse, yeast is nonessential ORTHOMCL1720: YDR284C, ENSP00000314854 YDR284C DPP1: Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism MGI:1919160 No phenotype data for mouse, yeast is nonessential ORTHOMCL6929: YPR129W, ENSP00000279068 YPR129W SCD6: Protein containing an Lsm domain, may bind RNA and have a role in RNA processing; overproduction suppresses a null mutation in CHC1, which encodes the heavy chain of clathrin MGI:3040677 No phenotype data for mouse, yeast is nonessential ORTHOMCL7419: YDL091C, ENSP00000261942 YDL091C UBX3: UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern MGI:1923827 No phenotype data for mouse, yeast is nonessential ORTHOMCL5420: YGR057C, ENSP00000285071 YGR057C LST7: Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface MGI:2442184 No phenotype data for mouse, yeast is nonessential ORTHOMCL6380: YGR019W, ENSP00000268251 YGR019W UGA1: Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization MGI:2443582 No phenotype data for mouse, yeast is essential ORTHOMCL5090: YBL097W, ENSP00000240423 YBL097W BRN1: Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics MGI:2444777 No phenotype data for mouse, yeast is nonessential ORTHOMCL8542: YDR286C, ENSP00000296662 YDR286C : Hypothetical protein MGI:1924672 No phenotype data for mouse, yeast is nonessential ORTHOMCL3053: YDR083W, ENSP00000254605 YDR083W RRP8: Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation MGI:1914251 No phenotype data for mouse, yeast is essential ORTHOMCL4310: YNL313C, ENSP00000313953 YNL313C : Protein required for cell viability MGI:1921446 No phenotype data for mouse, yeast is nonessential ORTHOMCL7640: YIR002C, ENSP00000267433 YIR002C MPH1: Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotype MGI:2442306 No phenotype data for mouse, yeast is essential ORTHOMCL5537: YPL076W, ENSP00000258324 YPL076W GPI2: Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein MGI:1914542 No phenotype data for mouse, yeast is essential ORTHOMCL5375: YLR316C, ENSP00000332448 YLR316C TAD3: Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs MGI:1928947 No phenotype data for mouse, yeast is nonessential ORTHOMCL5535: YML110C, ENSP00000288532 YML110C COQ5: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; located in mitochondria MGI:1098643 No phenotype data for mouse, yeast is nonessential ORTHOMCL5664: YPR065W, ENSP00000347646 YPR065W ROX1: Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity MGI:98360 Neither essential ORTHOMCL5642: YLR216C, ENSP00000303754 YLR216C CPR6: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity MGI:1914988 Ppid: peptidylprolyl isomerase D (cyclophilin D) No phenotype data for mouse, yeast is essential ORTHOMCL4443: YCR057C, ENSP00000291576 YCR057C PWP2: Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis MGI:1341200 No phenotype data for mouse, yeast is nonessential ORTHOMCL5407: YDL033C, ENSP00000290846 YDL033C SLM3: tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) MGI:1919276 No phenotype data for mouse, yeast is essential ORTHOMCL2859: YGR246C, ENSP00000329029 YGR246C BRF1: TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB MGI:1919558 No phenotype data for mouse, yeast is nonessential ORTHOMCL3796: YOR006C, ENSP00000007390 YOR006C : Hypothetical protein MGI:1915577 No phenotype data for mouse, yeast is nonessential ORTHOMCL4574: YNL286W, ENSP00000218364 YNL286W CUS2: Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) MGI:1919709 No phenotype data for mouse, yeast is essential ORTHOMCL4794: YOL010W, ENSP00000239262 YOL010W RCL1: RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activity MGI:1913275 No phenotype data for mouse, yeast is nonessential ORTHOMCL5501: YNL148C, ENSP00000221855 YNL148C ALF1: Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance MGI:1913661 No phenotype data for mouse, yeast is essential ORTHOMCL6860: YLR186W, ENSP00000261406 YLR186W EMG1: Protein required for the maturation of the 18S rRNA and for 40S ribosome production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind snoRNAs MGI:1315195 No systematic deletion data for yeast, no mouse data ORTHOMCL1993: YIL065C, ENSP00000223136 YIL065C MGI:1913687 No phenotype data for mouse, yeast is nonessential ORTHOMCL10682: YKR074W, ENSP00000352720 YKR074W : Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm MGI:1920353 No systematic deletion data for yeast, no mouse data ORTHOMCL947: YLR245C, ENSP00000289839 YLR245C MGI:1919519 Neither essential ORTHOMCL5194: YDR097C, ENSP00000234420 YDR097C MSH6: Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p MGI:1343961 Msh6: mutS homolog 6 (E. coli) No phenotype data for mouse, yeast is essential ORTHOMCL2127: YOR194C, ENSP00000298173 YOR194C TOA1: TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA MGI:1933277 No phenotype data for mouse, yeast is nonessential ORTHOMCL8144: YOL114C, ENSP00000301585 YOL114C : Hypothetical protein MGI:1915822 No phenotype data for mouse, yeast is nonessential ORTHOMCL3268: YGR096W, ENSP00000319574 YGR096W TPC1: Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family MGI:1914533 No phenotype data for mouse, yeast is essential ORTHOMCL5335: YJL008C, ENSP00000286788 YJL008C CCT8: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo MGI:107183 No phenotype data for mouse, yeast is nonessential ORTHOMCL2722: YBR115C, ENSP00000205214 YBR115C LYS2: Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p MGI:2442517 No phenotype data for mouse, yeast is nonessential ORTHOMCL7957: YOR125C, ENSP00000322316 YOR125C CAT5: Mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis, essential for several other metabolic pathways including respiration and gluconeogenic gene activation MGI:107207 No phenotype data for mouse, yeast is nonessential ORTHOMCL4740: YLR065C, ENSP00000340697 YLR065C : Putative protein of unknown function; YLR065C is not an essential gene MGI:1913570 No phenotype data for mouse, yeast is nonessential ORTHOMCL6861: YER078C, ENSP00000349658 YER078C : Metallopeptidase, localized to the mitochondrial matrix MGI:2445217 No phenotype data for mouse, yeast is nonessential ORTHOMCL3153: YNL224C, ENSP00000316109 YNL224C : Hypothetical protein MGI:1913799 No phenotype data for mouse, yeast is nonessential ORTHOMCL7931: YML030W, ENSP00000274787 YML030W : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential gene MGI:1914294 Both essential ORTHOMCL5096: YOR261C, ENSP00000219313 YOR261C RPN8: Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p MGI:1351511 Psmd7: proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 No phenotype data for mouse, yeast is nonessential ORTHOMCL6298: YLR191W, ENSP00000295030 YLR191W PEX13: Integral peroxisomal membrane receptor for the PTS1 peroxisomal matrix protein signal recognition factor Pex5p, required for the translocation of peroxisomal matrix proteins, also interacts with Pex7p and Pex14p, contains a C-terminal SH3 domain MGI:1919379 No phenotype data for mouse, yeast is nonessential ORTHOMCL3927: YBL013W, ENSP00000220058 YBL013W FMT1: Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate MGI:1916856 No phenotype data for mouse, yeast is nonessential ORTHOMCL4946: YCR027C, ENSP00000262187 YCR027C RHB1: Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins MGI:97912 No phenotype data for mouse, yeast is nonessential ORTHOMCL10140: YDR517W, ENSP00000313869 YDR517W GRH1: Protein involved in the spindle assembly checkpoint; homolog of human GRASP65, which is a Golgi localized protein that functions in postmitotic reassembly of Golgi stacks MGI:1921748 No phenotype data for mouse, yeast is essential ORTHOMCL3533: YLL018C, ENSP00000264161 YLL018C DPS1: Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation MGI:2442544 No phenotype data for mouse, yeast is essential ORTHOMCL3910: YER021W, ENSP00000264639 YER021W RPN3: Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control MGI:98858 No phenotype data for mouse, yeast is essential ORTHOMCL4408: YKL014C, ENSP00000270201 YKL014C URB1: Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit MGI:2146468 No phenotype data for mouse, yeast is nonessential ORTHOMCL1336: YOR241W, ENSP00000259403 YOR241W MET7: Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA MGI:95576 No phenotype data for mouse, yeast is essential ORTHOMCL3926: YNL102W, ENSP00000314415 YNL102W POL1: Catalytic subunit of the DNA polymerase alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis MGI:99660 No phenotype data for mouse, yeast is essential ORTHOMCL4427: YDR365C, ENSP00000202816 YDR365C ESF1: Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels MGI:1913830 Mouse only essential ORTHOMCL4990: YKR009C, ENSP00000256216 YKR009C FOX2: Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities MGI:105089 Hsd17b4: hydroxysteroid (17-beta) dehydrogenase 4 No phenotype data for mouse, yeast is nonessential ORTHOMCL3593: YOR289W, ENSP00000262844 YOR289W : Hypothetical protein MGI:1860206 Neither essential ORTHOMCL10131: YGL033W, ENSP00000253789 YGL033W HOP2: Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair MGI:1098610 Psmc3ip: proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein No phenotype data for mouse, yeast is nonessential ORTHOMCL3088: YBL036C, ENSP00000333551 YBL036C : Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificity MGI:1891207 Mouse only essential ORTHOMCL9550: YOL147C, ENSP00000300056 YOL147C PEX11: Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements MGI:1338788 Pex11a: peroxisomal biogenesis factor 11a No phenotype data for mouse, yeast is essential ORTHOMCL3890: YPR178W, ENSP00000344622 YPR178W PRP4: Splicing factor, component of the U4/U6-U5 snRNP complex MGI:1917302 No phenotype data for mouse, yeast is nonessential ORTHOMCL5584: YBR186W, ENSP00000166345 YBR186W PCH2: Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA MGI:1916966 No phenotype data for mouse, yeast is nonessential ORTHOMCL5950: YFR041C, ENSP00000259293 YFR041C ERJ5: Endoplasmic reticulum protein that may function as a cochaperone, as suggested by the presence of a DnaJ-like domain MGI:103268 No phenotype data for mouse, yeast is essential ORTHOMCL6972: YDL105W, ENSP00000263449 YDL105W NSE4: Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex MGI:1915122 No phenotype data for mouse, yeast is nonessential ORTHOMCL4623: YCL010C, ENSP00000316114 YCL010C SGF29: SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complex MGI:1922815 Neither essential ORTHOMCL1098: YDR256C, ENSP00000241052 YDR256C CTA1: Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation MGI:88271 Cat: catalase No phenotype data for mouse, yeast is essential ORTHOMCL8190: YOR281C, ENSP00000264254 YOR281C PLP2: Essential protein with similarity to phosducins, which are GTPase inhibitors; lethality of null mutation is functionally complemented by expression of mouse phosducin-like protein MgcPhLP MGI:1916083 No phenotype data for mouse, yeast is essential ORTHOMCL4358: YJR006W, ENSP00000223361 YJR006W HYS2: DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repair MGI:1097163 Neither essential ORTHOMCL3127: YDR386W, ENSP00000307853 YDR386W MUS81: Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p MGI:1918961 Mus81: MUS81 endonuclease homolog (yeast) Mouse only essential ORTHOMCL8947: YBR094W, ENSP00000233336 YBR094W : Hypothetical protein MGI:1916987 Ttl: tubulin tyrosine ligase Neither essential ORTHOMCL4130: YFR010W, ENSP00000261601 YFR010W UBP6: Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds MGI:1928898 Usp14: ubiquitin specific peptidase 14 Mouse only essential ORTHOMCL8072: YBL088C, ENSP00000278616 YBL088C TEL1: Protein kinase, primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene MGI:107202 Atm: ataxia telangiectasia mutated homolog (human) No phenotype data for mouse, yeast is nonessential ORTHOMCL4246: YJR122W, ENSP00000317297 YJR122W CAF17: Mitochondrial protein that interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteins MGI:3041174 No phenotype data for mouse, yeast is essential ORTHOMCL5603: YML105C, ENSP00000282999 YML105C SEC65: Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 MGI:1913634 No phenotype data for mouse, yeast is essential ORTHOMCL3445: YDL015C, ENSP00000215567 YDL015C TSC13: Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p MGI:1915408 No phenotype data for mouse, yeast is essential ORTHOMCL4226: YGL171W, ENSP00000268854 YGL171W ROK1: ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis MGI:1925644 No phenotype data for mouse, yeast is essential ORTHOMCL5201: YLR115W, ENSP00000298875 YLR115W CFT2: Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. MGI:1861601 No phenotype data for mouse, yeast is nonessential ORTHOMCL5131: YOL096C, ENSP00000254759 YOL096C COQ3: O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex MGI:101813 Mouse only essential ORTHOMCL5362: YDL090C, ENSP00000246166 YDL090C RAM1: Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit MGI:1861305 Fntb: farnesyltransferase, CAAX box, beta No phenotype data for mouse, yeast is nonessential ORTHOMCL5753: YAR035W, ENSP00000287862 YAR035W YAT1: Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix MGI:109176 No phenotype data for mouse, yeast is essential ORTHOMCL2818: YBL084C, ENSP00000066544 YBL084C CDC27: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition MGI:102685 No phenotype data for mouse, yeast is essential ORTHOMCL6146: YDL030W, ENSP00000329527 YDL030W PRP9: Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex MGI:1922312 No phenotype data for mouse, yeast is nonessential ORTHOMCL5880: YBR173C, ENSP00000255315 YBR173C UMP1: Short-lived chaperone required for correct maturation of the 20S proteasome; degraded by proteasome upon completion of its assembly; involved in ubiquitin-mediated proteolysis; mutant defective in degradation of short-lived proteins MGI:1913787 No phenotype data for mouse, yeast is essential ORTHOMCL4390: YOR077W, ENSP00000281372 YOR077W RTS2: Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication MGI:96676 No phenotype data for mouse, yeast is nonessential ORTHOMCL6591: YDR198C, ENSP00000329189 YDR198C RKM2: Ribosomal protein lysine methyltransferase MGI:2136890 No phenotype data for mouse, yeast is nonessential ORTHOMCL6577: YBR246W, ENSP00000277540 YBR246W : Hypothetical protein MGI:1914478 Both essential ORTHOMCL5602: YER112W, ENSP00000252816 YER112W LSM4: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA MGI:1354692 Lsm4: LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) No phenotype data for mouse, yeast is essential ORTHOMCL2926: YDR280W, ENSP00000243498 YDR280W RRP45: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex MGI:1355319 No phenotype data for mouse, yeast is essential ORTHOMCL3687: YDR091C, ENSP00000296577 YDR091C RLI1: Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase MGI:1195458 No phenotype data for mouse, yeast is nonessential ORTHOMCL6593: YDL122W, ENSP00000257548 YDL122W UBP1: Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains MGI:2140991 No phenotype data for mouse, yeast is essential ORTHOMCL4367: YBL035C, ENSP00000265465 YBL035C POL12: B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation MGI:99690 No phenotype data for mouse, yeast is nonessential ORTHOMCL5480: YLR192C, ENSP00000261868 YLR192C HCR1: Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA MGI:1925905 No phenotype data for mouse, yeast is essential ORTHOMCL3118: YJR064W, ENSP00000280326 YJR064W CCT5: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo MGI:107185 No phenotype data for mouse, yeast is essential ORTHOMCL6614: YIR012W, ENSP00000248450 YIR012W SQT1: Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay MGI:107809 No phenotype data for mouse, yeast is nonessential ORTHOMCL4988: YHR156C, ENSP00000304903 YHR156C LIN1: Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication MGI:1917483 No phenotype data for mouse, yeast is nonessential ORTHOMCL3855: YOR142W, ENSP00000295783 YOR142W LSC1: Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate MGI:1927234 No phenotype data for mouse, yeast is nonessential ORTHOMCL6505: YOR283W, ENSP00000179259 YOR283W : Hypothetical protein MGI:2442752 No phenotype data for mouse, yeast is essential ORTHOMCL5538: YDL098C, ENSP00000274712 YDL098C SNU23: Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome MGI:1913742 No phenotype data for mouse, yeast is nonessential ORTHOMCL5082: YLR059C, ENSP00000265881 YLR059C REX2: RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases MGI:1888981 No phenotype data for mouse, yeast is nonessential ORTHOMCL5829: YOL107W, ENSP00000266025 YOL107W : Hypothetical protein MGI:1930765 No phenotype data for mouse, yeast is nonessential ORTHOMCL3192: YHR026W, ENSP00000236067 YHR026W PPA1: Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain MGI:1890510 No phenotype data for mouse, yeast is nonessential ORTHOMCL700: YGR028W, ENSP00000260709 YGR028W MSP1: Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase MGI:1915229 Mouse only essential ORTHOMCL4051: YLL009C, ENSP00000261070 YLL009C COX17: Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase MGI:1333806 Cox17: cytochrome c oxidase, subunit XVII assembly protein homolog (yeast) No phenotype data for mouse, yeast is nonessential ORTHOMCL7588: YNL320W, ENSP00000267322 YNL320W : Hypothetical protein MGI:1916154 Neither essential ORTHOMCL4567: YGR123C, ENSP00000012443 YGR123C PPT1: Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth MGI:102666 Ppp5c: protein phosphatase 5, catalytic subunit No phenotype data for mouse, yeast is nonessential ORTHOMCL5462: YBR269C, ENSP00000284225 YBR269C FMP21: The authentic, non-tagged protein was localized to the mitochondria MGI:1915252 No phenotype data for mouse, yeast is nonessential ORTHOMCL2667: YMR188C, ENSP00000285298 YMR188C MRPS17: Mitochondrial ribosomal protein of the small subunit MGI:1913508 No phenotype data for mouse, yeast is essential ORTHOMCL6123: YNL075W, ENSP00000259239 YNL075W IMP4: Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs MGI:106572 No phenotype data for mouse, yeast is essential ORTHOMCL2540: YOR095C, ENSP00000283646 YOR095C RKI1: Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis MGI:103254 No phenotype data for mouse, yeast is nonessential ORTHOMCL3950: YKL197C, ENSP00000248633 YKL197C PEX1: AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettes MGI:1918632 No phenotype data for mouse, yeast is nonessential ORTHOMCL6811: YOR253W, ENSP00000240922 YOR253W NAT5: Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing MGI:1919367 No phenotype data for mouse, yeast is essential ORTHOMCL6810: YDL029W, ENSP00000260641 YDL029W ARP2: Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity MGI:1913963 No phenotype data for mouse, yeast is essential ORTHOMCL5821: YPR082C, ENSP00000269601 YPR082C DIB1: 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of the human U5-specific 15-kDa protein MGI:1351613 No phenotype data for mouse, yeast is essential ORTHOMCL4205: YNR003C, ENSP00000318757 YNR003C RPC34: RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex MGI:1924086 No phenotype data for mouse, yeast is nonessential ORTHOMCL4052: YOR150W, ENSP00000306548 YOR150W MRPL23: Mitochondrial ribosomal protein of the large subunit MGI:2137218 No phenotype data for mouse, yeast is essential ORTHOMCL6088: YNL261W, ENSP00000297431 YNL261W ORC5: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing MGI:1347044 No systematic deletion data for yeast, no mouse data ORTHOMCL4608: YLR383W, ENSP00000323439 YLR383W MGI:1914491 No phenotype data for mouse, yeast is nonessential ORTHOMCL5641: YDR140W, ENSP00000303584 YDR140W MTQ2: S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmC MGI:1915018 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000031189 ORTHOMCL4521: YJL062W, ENSP00000311750 YJL062W LAS21: Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity No phenotype data for mouse, yeast is nonessential ORTHOMCL7289: YNL252C, ENSP00000312311 YNL252C MRPL17: Mitochondrial ribosomal protein of the large subunit MGI:1914558 No phenotype data for mouse, yeast is nonessential ORTHOMCL5021: YBR164C, ENSP00000261636 YBR164C ARL1: Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor MGI:99436 No phenotype data for mouse, yeast is nonessential ORTHOMCL6206: YBR217W, ENSP00000274459 YBR217W ATG12: Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagy MGI:1914776 No phenotype data for mouse, yeast is essential ORTHOMCL4733: YDR376W, ENSP00000293195 YDR376W ARH1: Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability MGI:104724 No systematic deletion data for yeast, no mouse data ORTHOMCL8796: Q0045, ENSP00000354499 Q0045 MGI:102504 No phenotype data for mouse, yeast is essential ORTHOMCL4003: YDL007W, ENSP00000261303 YDL007W RPT2: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle MGI:106054 No systematic deletion data for yeast, no mouse data ORTHOMCL5193: YOR145C, ENSP00000263657 YOR145C MGI:1913499 No phenotype data for mouse, yeast is essential ORTHOMCL4105: YOR287C, ENSP00000244496 YOR287C : Protein required for cell viability MGI:2385053 No phenotype data for mouse, yeast is nonessential ORTHOMCL16966: YJR036C, ENSP00000298068 YJR036C HUL4: Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability MGI:2442663 No phenotype data for mouse, yeast is nonessential ORTHOMCL12217: YDL119C, ENSP00000273158 YDL119C : Putative mitochondrial transport protein; localizes to the mitochondrion; YDL119C is not an essential gene MGI:2384782 No phenotype data for mouse, yeast is essential ORTHOMCL5246: YDR054C, ENSP00000263228 YDR054C CDC34: Ubiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p, Cdc53p, and an F-box protein, forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation MGI:1914865 Both essential ORTHOMCL6931: YHR190W, ENSP00000220584 YHR190W ERG9: Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway MGI:102706 Fdft1: farnesyl diphosphate farnesyl transferase 1 No phenotype data for mouse, yeast is nonessential ORTHOMCL4236: YLR386W, ENSP00000261776 YLR386W VAC14: Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; activator of Fab1p MGI:2157980 No phenotype data for mouse, yeast is nonessential ORTHOMCL5022: YPL097W, ENSP00000320658 YPL097W MSY1: Mitochondrial tyrosyl-tRNA synthetase MGI:1917370 Both essential ORTHOMCL6165: YLR103C, ENSP00000263201 YLR103C CDC45: DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes MGI:1338073 Cdc45l: cell division cycle 45 homolog (S. cerevisiae)-like No phenotype data for mouse, yeast is nonessential ORTHOMCL5735: YPL222W, ENSP00000248845 YPL222W FMP40: The authentic, non-tagged protein was localized to the mitochondria. MGI:1919007 No phenotype data for mouse, yeast is nonessential ORTHOMCL2506: YCL045C, ENSP00000264214 YCL045C : Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; interacts with Gal80p; YCL045C is not an essential gene MGI:2443696 No phenotype data for mouse, yeast is essential ORTHOMCL3779: YJL111W, ENSP00000258091 YJL111W CCT7: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo MGI:107184 No phenotype data for mouse, yeast is nonessential ORTHOMCL7464: YBR278W, ENSP00000233699 YBR278W DPB3: Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle MGI:1914229 No phenotype data for mouse, yeast is essential ORTHOMCL5414: YDR236C, ENSP00000257452 YDR236C FMN1: Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane MGI:1914688 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000032461 ORTHOMCL4481: YGR046W, ENSP00000273037 YGR046W : Putative protein of unknown function; mRNA is targeted to the bud via the mRNA transport system involving She2p; deletion mutant is inviable No phenotype data for mouse, yeast is nonessential ORTHOMCL2264: YMR130W, ENSP00000238379 YMR130W : Hypothetical protein MGI:1919998 No phenotype data for mouse, yeast is nonessential ORTHOMCL12875: YCR002C, ENSP00000329161 YCR002C CDC10: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EM MGI:1858222 No phenotype data for mouse, yeast is essential ORTHOMCL4999: YJL002C, ENSP00000296255 YJL002C OST1: Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins MGI:98084 No systematic deletion data for yeast, no mouse data ORTHOMCL7158: Q0275, ENSP00000354982 Q0275 MGI:102502 No phenotype data for mouse, yeast is nonessential ORTHOMCL6479: YDL072C, ENSP00000343458 YDL072C YET3: Endoplasmic reticulum transmembrane protein, homolog of human BAP31 protein MGI:1350933 No phenotype data for mouse, yeast is nonessential ORTHOMCL4784: YPL086C, ENSP00000256398 YPL086C ELP3: Histone acetyltransferase subunit of the Elongator complex, which is a component of the RNA polymerase II holoenzyme; activity is directed specifically towards histones H3 and H4; disruption confers resistance to K. lactis zymotoxin MGI:1921445 Mouse only essential ORTHOMCL16679: YBR023C, ENSP00000306991 YBR023C CHS3: Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan MGI:107821 Has2: hyaluronan synthase 2 Mouse only essential ORTHOMCL7529: YDR142C, ENSP00000315680 YDR142C PEX7: Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) MGI:1321392 Pex7: peroxisome biogenesis factor 7 Mouse only essential ORTHOMCL3265: YIL049W, ENSP00000264228 YIL049W DFG10: Protein of unknown function, involved in filamentous growth MGI:1930252 Srd5a2l: steroid 5 alpha-reductase 2-like No phenotype data for mouse, yeast is nonessential ORTHOMCL4627: YNL202W, ENSP00000219481 YNL202W SPS19: Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate MGI:1347059 No phenotype data for mouse, yeast is nonessential ORTHOMCL2018: YDR092W, ENSP00000316176 YDR092W UBC13: Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus MGI:1934835 No phenotype data for mouse, yeast is nonessential ORTHOMCL6369: YIL097W, ENSP00000302830 YIL097W FYV10: Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domain MGI:1891748 No phenotype data for mouse, yeast is nonessential ORTHOMCL12499: YDR006C, ENSP00000299045 YDR006C SOK1: Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 MGI:2444679 No phenotype data for mouse, yeast is nonessential ORTHOMCL2300: YNL325C, ENSP00000230124 YNL325C FIG4: Protein required for efficient mating, member of a family of eukaryotic proteins that contain a domain homologous to Sac1p MGI:2143585 No phenotype data for mouse, yeast is nonessential ORTHOMCL4985: YNL001W, ENSP00000274311 YNL001W DOM34: Probable RNA-binding protein, functions in protein translation to promote G1 progression and differentiation, required for meiotic cell division MGI:2145154 No phenotype data for mouse, yeast is essential ORTHOMCL5866: YOL146W, ENSP00000318196 YOL146W PSF3: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery MGI:1926083 No phenotype data for mouse, yeast is essential ORTHOMCL5134: YHR062C, ENSP00000277882 YHR062C RPP1: Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends MGI:1859683 Mouse only essential ORTHOMCL4274: YPL022W, ENSP00000310520 YPL022W RAD1: Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein MGI:1354163 Ercc4: excision repair cross-complementing rodent repair deficiency, complementation group 4 No phenotype data for mouse, yeast is essential ORTHOMCL4472: YJL050W, ENSP00000230640 YJL050W MTR4: Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNA MGI:1919448 No phenotype data for mouse, yeast is essential ORTHOMCL4610: YLR051C, ENSP00000183866 YLR051C FCF2: Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon MGI:1923173 No systematic deletion data for yeast, no mouse data ORTHOMCL9980: YOL086W-A, ENSP00000308583 YOL086W-A MGI:1917178 No phenotype data for mouse, yeast is essential ORTHOMCL7377: YGL018C, ENSP00000216027 YGL018C JAC1: Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix MGI:2141135 No phenotype data for mouse, yeast is nonessential ORTHOMCL4256: YPL013C, ENSP00000299418 YPL013C MRPS16: Mitochondrial ribosomal protein of the small subunit MGI:1913492 No phenotype data for mouse, yeast is nonessential ORTHOMCL6007: YDR221W, ENSP00000252455 YDR221W GTB1: Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER MGI:107877 No phenotype data for mouse, yeast is essential ORTHOMCL5933: YGR264C, ENSP00000262027 YGR264C MES1: Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs MGI:1345633 No phenotype data for mouse, yeast is nonessential ORTHOMCL4844: YPL030W, ENSP00000315671 YPL030W : Hypothetical protein MGI:1926140 No phenotype data for mouse, yeast is essential ORTHOMCL4164: YPR108W, ENSP00000295901 YPR108W RPN7: Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits MGI:1913663 Mouse only essential ORTHOMCL5579: YGR112W, ENSP00000277404 YGR112W SHY1: Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster MGI:98443 Surf1: surfeit gene 1 No phenotype data for mouse, yeast is essential ORTHOMCL5869: YDR398W, ENSP00000296126 YDR398W UTP5: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA MGI:1919765 No phenotype data for mouse, yeast is nonessential ORTHOMCL5542: YNL168C, ENSP00000314622 YNL168C FMP41: The authentic, non-tagged protein was localized to mitochondria MGI:1915886 No phenotype data for mouse, yeast is nonessential ORTHOMCL5536: YJR010C-A, ENSP00000233025 YJR010C-A SPC1: Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex MGI:1916269 No phenotype data for mouse, yeast is essential ORTHOMCL5210: YPL266W, ENSP00000199320 YPL266W DIM1: Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing MGI:1913504 Mouse only essential ORTHOMCL3584: YDR410C, ENSP00000313340 YDR410C STE14: Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane MGI:1888594 Icmt: isoprenylcysteine carboxyl methyltransferase No phenotype data for mouse, yeast is nonessential ORTHOMCL14041: YGL059W, ENSP00000005178 YGL059W : Hypothetical protein MGI:1351481 No phenotype data for mouse, yeast is essential ORTHOMCL3447: YDR325W, ENSP00000251496 YDR325W YCG1: Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex MGI:1930197 No phenotype data for mouse, yeast is essential ORTHOMCL6683: YGL040C, ENSP00000277315 YGL040C HEM2: Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus MGI:96853 No phenotype data for mouse, yeast is essential ORTHOMCL3004: YOR259C, ENSP00000216407 YOR259C RPT4: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycle MGI:1914339 No phenotype data for mouse, yeast is essential ORTHOMCL3880: YBL041W, ENSP00000262193 YBL041W PRE7: 20S proteasome beta-type subunit MGI:104884 No phenotype data for mouse, yeast is essential ORTHOMCL5003: YKL045W, ENSP00000274891 YKL045W PRI2: Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair MGI:97758 No phenotype data for mouse, yeast is nonessential ORTHOMCL6377: YLR017W, ENSP00000297736 YLR017W MEU1: Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression MGI:1914152 No phenotype data for mouse, yeast is nonessential ORTHOMCL2111: YJL044C, ENSP00000253692 YJL044C GYP6: GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport MGI:1919488 No phenotype data for mouse, yeast is nonessential ORTHOMCL4779: YJL101C, ENSP00000229416 YJL101C GSH1: Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury MGI:104990 No phenotype data for mouse, yeast is nonessential ORTHOMCL6149: YKL047W, ENSP00000297761 YKL047W : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm MGI:2444256 No phenotype data for mouse, yeast is nonessential ORTHOMCL4746: YPL183W-A, ENSP00000306151 YPL183W-A : Homolog of the prokaryotic ribosomal protein L36, likely to be a mitochondrial ribosomal protein coded in the nuclear genome MGI:2137228 Both essential ORTHOMCL3333: YGR098C, ENSP00000257934 YGR098C ESP1: Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibited by Pds1p MGI:2146156 Espl1: extra spindle poles-like 1 (S. cerevisiae) No phenotype data for mouse, yeast is essential ORTHOMCL1908: YGL011C, ENSP00000261479 YGL011C SCL1: Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondria MGI:1347006 No phenotype data for mouse, yeast is nonessential ORTHOMCL3390: YBR133C, ENSP00000319169 YBR133C HSL7: Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p MGI:1351645 No phenotype data for mouse, yeast is nonessential ORTHOMCL4111: YPL001W, ENSP00000264108 YPL001W HAT1: Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair MGI:96013 Both essential ORTHOMCL3310: YDR047W, ENSP00000246337 YDR047W HEM12: Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents MGI:98916 Urod: uroporphyrinogen decarboxylase No systematic deletion data for yeast, no mouse data ORTHOMCL4933: YHR169W, ENSP00000247003 YHR169W MGI:2136689 No phenotype data for mouse, yeast is nonessential ORTHOMCL1727: YBR159W, ENSP00000278353 YBR159W IFA38: Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides. MGI:1926967 No phenotype data for mouse, yeast is essential ORTHOMCL4817: YOR210W, ENSP00000324124 YOR210W RPB10: RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III MGI:1913741 No phenotype data for mouse, yeast is essential ORTHOMCL2682: YOR057W, ENSP00000298172 YOR057W SGT1: Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex MGI:1915205 No phenotype data for mouse, yeast is essential ORTHOMCL4435: YGR091W, ENSP00000324122 YGR091W PRP31: Splicing factor, component of the U4/U6-U5 snRNP complex MGI:1916238 No phenotype data for mouse, yeast is nonessential ORTHOMCL6214: YGL244W, ENSP00000260373 YGL244W RTF1: Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenance MGI:1309480 No phenotype data for mouse, yeast is essential ORTHOMCL3822: YJR068W, ENSP00000296273 YJR068W RFC2: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon MGI:2146571 Neither essential ORTHOMCL4391: YDL168W, ENSP00000296412 YDL168W SFA1: Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p MGI:87929 Adh5: alcohol dehydrogenase 5 (class III), chi polypeptide No phenotype data for mouse, yeast is nonessential ORTHOMCL6394: YOL003C, ENSP00000342781 YOL003C PFA4: Palmitoyltransferase with autoacylation activity, required for modification and ER export of Chs3p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain MGI:3045252 No phenotype data for mouse, yeast is essential ORTHOMCL2732: YCR093W, ENSP00000320949 YCR093W CDC39: Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor MGI:2442402 No phenotype data for mouse, yeast is nonessential ORTHOMCL2778: YMR300C, ENSP00000264220 YMR300C ADE4: Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway MGI:2387203 No phenotype data for mouse, yeast is nonessential ORTHOMCL6039: YLR418C, ENSP00000256767 YLR418C CDC73: Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenance MGI:2384876 No phenotype data for mouse, yeast is nonessential ORTHOMCL3846: YGL136C, ENSP00000327660 YGL136C MRM2: Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ MGI:1915267 Both essential ORTHOMCL2799: YGR211W, ENSP00000227322 YGR211W ZPR1: Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) MGI:1330262 Zfp259: zinc finger protein 259 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000030913 ORTHOMCL7733: YDR265W, ENSP00000288774 YDR265W PEX10: RING finger peroxisomal membrane peroxin required for peroxisomal matrix protein import, interacts with Pex12p, links ubiquitin-conjugating Pex4p to protein import machinery; mutations in human homolog cause a variety of peroxisomal disorders No phenotype data for mouse, yeast is nonessential ORTHOMCL15196: YBL007C, ENSP00000309186 YBL007C SLA1: Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosis MGI:2444637 No phenotype data for mouse, yeast is nonessential ORTHOMCL5983: YHL031C, ENSP00000225724 YHL031C GOS1: v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 MGI:1858260 Yeast only essential ORTHOMCL4484: YER159C, ENSP00000307850 YER159C BUR6: Protein that forms a heterodimeric histone-fold NC2 general transcription regulator complex with Ydr1p that binds to TBP and represses RNA pol II transcription during assembly of the preinitiation complex, homologous to human NC2alpha MGI:1913806 Drap1: Dr1 associated protein 1 (negative cofactor 2 alpha) No phenotype data for mouse, yeast is essential ORTHOMCL5264: YPR056W, ENSP00000228955 YPR056W TFB4: Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p MGI:1277143 No phenotype data for mouse, yeast is essential ORTHOMCL11215: YIL003W, ENSP00000262302 YIL003W CFD1: Highly conserved, putative P-loop ATPase localized in the cytoplasm; has a potential role in assembly of iron-sulfur clusters in proteins MGI:1347072 No phenotype data for mouse, yeast is essential ORTHOMCL3974: YPR144C, ENSP00000328854 YPR144C NOC4: Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits MGI:2140843 No phenotype data for mouse, yeast is nonessential ORTHOMCL4514: YLR172C, ENSP00000251159 YLR172C DPH5: Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm MGI:1916990 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000020440 ORTHOMCL5621: YGR181W, ENSP00000215570 YGR181W TIM13: Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner No phenotype data for mouse, yeast is nonessential ORTHOMCL12819: YJL036W, ENSP00000251775 YJL036W SNX4: Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20p MGI:1916400 Neither essential ORTHOMCL5220: YPL172C, ENSP00000261643 YPL172C COX10: Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders MGI:1917633 Cox10: COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) No phenotype data for mouse, yeast is essential ORTHOMCL4502: YNL262W, ENSP00000322570 YNL262W POL2: Catalytic subunit of DNA polymerase epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair MGI:1196391 No phenotype data for mouse, yeast is essential ORTHOMCL4203: YKL182W, ENSP00000290429 YKL182W FAS1: Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities MGI:2388651 No phenotype data for mouse, yeast is nonessential ORTHOMCL4123: YPL244C, ENSP00000240333 YPL244C HUT1: Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 MGI:1343133 No phenotype data for mouse, yeast is nonessential ORTHOMCL5236: YGL231C, ENSP00000267750 YGL231C : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum MGI:1915282 No phenotype data for mouse, yeast is nonessential ORTHOMCL8219: YDL200C, ENSP00000302111 YDL200C MGT1: DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage MGI:96977 No phenotype data for mouse, yeast is nonessential ORTHOMCL6523: YFL027C, ENSP00000246077 YFL027C GYP8: GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport MGI:1914481 No phenotype data for mouse, yeast is nonessential ORTHOMCL2014: YLR380W, ENSP00000252430 YLR380W CSR1: Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistance MGI:1924013 No phenotype data for mouse, yeast is nonessential ORTHOMCL3833: YGR194C, ENSP00000207870 YGR194C XKS1: Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains MGI:2142985 No phenotype data for mouse, yeast is nonessential ORTHOMCL3709: YGR078C, ENSP00000286428 YGR078C PAC10: Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding MGI:1333804 No phenotype data for mouse, yeast is essential ORTHOMCL7867: YDR302W, ENSP00000281382 YDR302W GPI11: ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog MGI:99462 No phenotype data for mouse, yeast is nonessential ORTHOMCL3866: YLR382C, ENSP00000265537 YLR382C NAM2: Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance MGI:2142973 No phenotype data for mouse, yeast is nonessential ORTHOMCL550: YBL021C, ENSP00000240055 YBL021C HAP3: Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding MGI:97317 No phenotype data for mouse, yeast is essential ORTHOMCL4704: YPR094W, ENSP00000216252 YPR094W RDS3: Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance MGI:2156864 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000070002 ORTHOMCL2451: YNL246W, ENSP00000318012 YNL246W VPS75: Protein of unknown function involved in vacuolar protein sorting; detected in the nucleus No phenotype data for mouse, yeast is essential ORTHOMCL2691: YER012W, ENSP00000246311 YER012W PRE1: 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycle MGI:1347045 No phenotype data for mouse, yeast is nonessential ORTHOMCL7877: YLR281C, ENSP00000253233 YLR281C : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene MGI:1919900 No phenotype data for mouse, yeast is nonessential ORTHOMCL6949: YLR114C, ENSP00000315568 YLR114C AVL9: Mutation is syntheticly lethal with apl2 vps1 double mutant MGI:1926187 No phenotype data for mouse, yeast is essential ORTHOMCL4355: YJR072C, ENSP00000264718 YJR072C NPA3: Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complex MGI:1921504 No phenotype data for mouse, yeast is essential ORTHOMCL3077: YDR267C, ENSP00000272402 YDR267C CIA1: Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins MGI:1346998 No phenotype data for mouse, yeast is nonessential ORTHOMCL8373: YNL063W, ENSP00000232854 YNL063W MTQ1: S-adenosylmethionine-dependent Methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene MGI:1916786 No phenotype data for mouse, yeast is nonessential ORTHOMCL3998: YLR439W, ENSP00000259038 YLR439W MRPL4: Mitochondrial ribosomal protein of the large subunit MGI:1921850 No phenotype data for mouse, yeast is nonessential ORTHOMCL6044: YCL055W, ENSP00000274028 YCL055W KAR4: Transcription factor required for induction of KAR3 and CIK1 during mating, also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone MGI:2442926 No phenotype data for mouse, yeast is nonessential ORTHOMCL6612: YDR057W, ENSP00000185150 YDR057W YOS9: Lectin; soluble lumenal ER protein; member of the OS-9 protein family; similar to mannose-6-phosphate receptors (MPRs); serves as a receptor that recognizes misfolded N-glycosylated proteins and participates in their targeting to ERAD MGI:1914003 No phenotype data for mouse, yeast is essential ORTHOMCL4142: YDR212W, ENSP00000239585 YDR212W TCP1: Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide MGI:98535 Both essential ORTHOMCL3968: YOR103C, ENSP00000250498 YOR103C OST2: Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins MGI:101912 Dad1: defender against cell death 1 No phenotype data for mouse, yeast is nonessential ORTHOMCL5162: YNL035C, ENSP00000267522 YNL035C : Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene MGI:1919588 No phenotype data for mouse, yeast is essential ORTHOMCL3027: YOR254C, ENSP00000027474 YOR254C SEC63: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER MGI:2155302 No phenotype data for mouse, yeast is nonessential ORTHOMCL2560: YGL174W, ENSP00000260210 YGL174W BUD13: Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern MGI:2443443 No phenotype data for mouse, yeast is essential ORTHOMCL5364: YGR145W, ENSP00000263836 YGR145W ENP2: Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p MGI:2684913 No phenotype data for mouse, yeast is essential ORTHOMCL4257: YDR404C, ENSP00000301788 YDR404C RPB7: RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p MGI:1914960 No phenotype data for mouse, yeast is nonessential ORTHOMCL8637: YOR078W, ENSP00000259969 YOR078W BUD21: Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern MGI:1917328 No phenotype data for mouse, yeast is nonessential ORTHOMCL6081: YPR040W, ENSP00000315469 YPR040W TIP41: Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway MGI:1915087 No phenotype data for mouse, yeast is essential ORTHOMCL4531: YIL004C, ENSP00000222547 YIL004C BET1: Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins MGI:1343104 No phenotype data for mouse, yeast is essential ORTHOMCL3630: YHR085W, ENSP00000344645 YHR085W IPI1: Protein of unknown function, essential for viability, may be involved in rRNA processing MGI:1344413 No phenotype data for mouse, yeast is nonessential ORTHOMCL13075: YMR004W, ENSP00000222990 YMR004W MVP1: Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole MGI:2443816 No phenotype data for mouse, yeast is essential ORTHOMCL8088: YDR168W, ENSP00000222005 YDR168W CDC37: Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle MGI:109531 No phenotype data for mouse, yeast is nonessential ORTHOMCL3234: YBL099W, ENSP00000282050 YBL099W ATP1: Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis MGI:88115 No phenotype data for mouse, yeast is essential ORTHOMCL5993: YLR359W, ENSP00000216194 YLR359W ADE13: Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway MGI:103202 No phenotype data for mouse, yeast is essential ORTHOMCL5297: YPL217C, ENSP00000298600 YPL217C BMS1: Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1p MGI:2446132 Neither essential ORTHOMCL5487: YJL073W, ENSP00000218763 YJL073W JEM1: DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 MGI:107373 Dnajc3: DnaJ (Hsp40) homolog, subfamily C, member 3 No phenotype data for mouse, yeast is nonessential ORTHOMCL1837: YLR038C, ENSP00000246554 YLR038C COX12: Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assembly MGI:107460 No phenotype data for mouse, yeast is nonessential ORTHOMCL4877: YOL071W, ENSP00000301761 YOL071W EMI5: Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation MGI:1913322 No phenotype data for mouse, yeast is essential ORTHOMCL3551: YDR044W, ENSP00000264193 YDR044W HEM13: Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) MGI:104841 No phenotype data for mouse, yeast is nonessential ORTHOMCL1589: YER178W, ENSP00000254142 YER178W PDA1: E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucose MGI:97532 No phenotype data for mouse, yeast is nonessential ORTHOMCL3864: YNR032C-A, ENSP00000351492 YNR032C-A HUB1: Ubiquitin-like protein modifier, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanism of Hub1p adduct formation not yet clear MGI:1913427 No phenotype data for mouse, yeast is nonessential ORTHOMCL8857: YOR252W, ENSP00000351380 YOR252W TMA16: Protein of unknown function that associates with ribosomes MGI:1913532 No phenotype data for mouse, yeast is nonessential ORTHOMCL13073: YDR115W, ENSP00000252602 YDR115W : Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins MGI:2137227 No phenotype data for mouse, yeast is essential ORTHOMCL5563: YBR060C, ENSP00000234296 YBR060C ORC2: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p MGI:1328306 No systematic deletion data for yeast, no mouse data ORTHOMCL4394: YPR021C, ENSP00000263812 YPR021C MGI:1926080 No phenotype data for mouse, yeast is nonessential ORTHOMCL3220: YJL124C, ENSP00000310596 YJL124C LSM1: Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs MGI:1914457 No phenotype data for mouse, yeast is essential ORTHOMCL6734: YGL091C, ENSP00000283027 YGL091C NBP35: Essential nuclear protein, evolutionarily conserved putative ATPase; exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase delta MGI:1347073 Neither essential ORTHOMCL1554: YER042W, ENSP00000313921 YER042W MXR1: Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan MGI:106916 Msra: methionine sulfoxide reductase A No phenotype data for mouse, yeast is nonessential ORTHOMCL2400: YAL035W, ENSP00000289371 YAL035W FUN12: GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 MGI:2441772 No phenotype data for mouse, yeast is nonessential ORTHOMCL10064: YHR181W, ENSP00000272438 YHR181W SVP26: Integral membrane protein of the early Golgi apparatus, may function to promote retention of proteins in the early Golgi compartment; mutation affects protein N-glycosylation and cell wall integrity MGI:1096575 Neither essential ORTHOMCL2040: YNL045W, ENSP00000228740 YNL045W : Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus MGI:96836 Lta4h: leukotriene A4 hydrolase No phenotype data for mouse, yeast is essential ORTHOMCL4537: YBR080C, ENSP00000225282 YBR080C SEC18: ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF MGI:104560 No phenotype data for mouse, yeast is nonessential ORTHOMCL2794: YMR009W, ENSP00000333666 YMR009W ADI1: Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions MGI:2144929 No phenotype data for mouse, yeast is nonessential ORTHOMCL3963: YOR243C, ENSP00000348722 YOR243C PUS7: Pseudouridine synthase, catalyzes pseudouridylation at position 35 in U2 snRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); Asp(256) mutation abolishes activity; conserved in archaea, some bacteria, and vertebrates MGI:1925947 No phenotype data for mouse, yeast is nonessential ORTHOMCL6045: YBR235W, ENSP00000275730 YBR235W : Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene MGI:1933532 No phenotype data for mouse, yeast is essential ORTHOMCL4553: YFL002C, ENSP00000238146 YFL002C SPB4: Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients MGI:1915098 No phenotype data for mouse, yeast is essential ORTHOMCL5790: YLR424W, ENSP00000263115 YLR424W SPP382: Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation MGI:1930075 No phenotype data for mouse, yeast is nonessential ORTHOMCL16396: YER005W, ENSP00000347031 YER005W YND1: Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1p MGI:2135885 Both essential ORTHOMCL4160: YBR243C, ENSP00000346142 YBR243C ALG7: UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin MGI:1196396 Dpagt1: dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) No phenotype data for mouse, yeast is essential ORTHOMCL11758: YFR027W, ENSP00000269214 YFR027W ECO1: Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication, but not for its maintenance during G2 and M phases; also required for postreplicative double-strand break repair; interacts with Chl1p MGI:1925055 No phenotype data for mouse, yeast is essential ORTHOMCL2093: YGL137W, ENSP00000329419 YGL137W SEC27: Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP MGI:1354962 No phenotype data for mouse, yeast is nonessential ORTHOMCL6658: YML005W, ENSP00000329858 YML005W TRM12: S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA MGI:1915510 Mouse only essential ORTHOMCL4702: YMR234W, ENSP00000313350 YMR234W RNH1: Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand MGI:1335073 Rnaseh1: ribonuclease H1 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000028470 ORTHOMCL4179: YHR005C-A, ENSP00000257245 YHR005C-A MRS11: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that mediates insertion of hydrophobic proteins at the inner membrane, has homology to Mrs5p, which is also involved in this process No phenotype data for mouse, yeast is nonessential ORTHOMCL5120: YFL030W, ENSP00000302620 YFL030W AGX1: Alanine : glyoxylate aminotransferase, catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine : glyoxylate aminotransferases MGI:1329033 No phenotype data for mouse, yeast is nonessential ORTHOMCL4487: YPR166C, ENSP00000239463 YPR166C MRP2: Mitochondrial ribosomal protein of the small subunit MGI:1928141 No phenotype data for mouse, yeast is essential ORTHOMCL4508: YGR074W, ENSP00000300413 YGR074W SMD1: Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1 MGI:98344 No phenotype data for mouse, yeast is nonessential ORTHOMCL4705: YBR146W, ENSP00000258455 YBR146W MRPS9: Mitochondrial ribosomal protein of the small subunit MGI:1916777 No phenotype data for mouse, yeast is essential ORTHOMCL6636: YDR013W, ENSP00000262460 YDR013W PSF1: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery MGI:1916520 No phenotype data for mouse, yeast is essential ORTHOMCL6609: YPL043W, ENSP00000223073 YPL043W NOP4: Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) MGI:2655711 No phenotype data for mouse, yeast is essential ORTHOMCL6212: YGR186W, ENSP00000245811 YGR186W TFG1: TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 MGI:1923848 No phenotype data for mouse, yeast is nonessential ORTHOMCL12548: YDL156W, ENSP00000263795 YDL156W : Hypothetical protein MGI:1926186 No phenotype data for mouse, yeast is essential ORTHOMCL3651: YLR196W, ENSP00000258531 YLR196W PWP1: Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily MGI:1914735 No phenotype data for mouse, yeast is essential ORTHOMCL5069: YDR190C, ENSP00000318297 YDR190C RVB1: Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family MGI:1928760 No phenotype data for mouse, yeast is essential ORTHOMCL4949: YBL004W, ENSP00000261637 YBL004W UTP20: Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA MGI:1917933 No phenotype data for mouse, yeast is essential ORTHOMCL6236: YDR449C, ENSP00000261708 YDR449C UTP6: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA MGI:2445193 No phenotype data for mouse, yeast is essential ORTHOMCL5624: YER126C, ENSP00000296802 YER126C NSA2: Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis MGI:1913883 No phenotype data for mouse, yeast is nonessential ORTHOMCL5969: YLR201C, ENSP00000262507 YLR201C COQ9: Mitochondrial inner membrane protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; exhibits genetic interaction with ABC1, suggesting a possible common function MGI:1915164 No phenotype data for mouse, yeast is nonessential ORTHOMCL4315: YGR020C, ENSP00000249289 YGR020C VMA7: Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane MGI:1913394 No phenotype data for mouse, yeast is nonessential ORTHOMCL7823: YDR432W, ENSP00000309558 YDR432W NPL3: RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; phosphorylation by Sky1p in the cytoplasm may promote release of mRNAs MGI:1917689 No phenotype data for mouse, yeast is nonessential ORTHOMCL6804: YBR231C, ENSP00000283882 YBR231C SWC5: Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin MGI:1344403 No phenotype data for mouse, yeast is essential ORTHOMCL5052: YER082C, ENSP00000266008 YER082C UTP7: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA MGI:1931871 Unknown phenotype: Deprecated MOUSE ID: ENSMUSP00000064153 ORTHOMCL6292: YBL020W, ENSP00000296292 YBL020W RFT1: Flippase, essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane; mutation is suppressed by expression human p53 protein No phenotype data for mouse, yeast is nonessential ORTHOMCL1309: YBR127C, ENSP00000276390 YBR127C VMA2: Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm MGI:109618 Neither essential ORTHOMCL10670: YBR276C, ENSP00000239223 YBR276C PPS1: Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle MGI:105120 Dusp1: dual specificity phosphatase 1 No phenotype data for mouse, yeast is nonessential ORTHOMCL5085: YPL178W, ENSP00000326806 YPL178W CBC2: Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif MGI:1915342 No systematic deletion data for yeast, no mouse data ORTHOMCL525: YNL036W, ENSP00000266263 YNL036W MGI:1916686 No phenotype data for mouse, yeast is nonessential ORTHOMCL3042: YNL005C, ENSP00000225969 YNL005C MRP7: Mitochondrial ribosomal protein of the large subunit MGI:2137224 No phenotype data for mouse, yeast is nonessential ORTHOMCL8043: YGR223C, ENSP00000348848 YGR223C HSV2: Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization MGI:1859606 No phenotype data for mouse, yeast is nonessential ORTHOMCL6401: YAR003W, ENSP00000264515 YAR003W SWD1: Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 MGI:1918367 No phenotype data for mouse, yeast is essential ORTHOMCL4941: YNL172W, ENSP00000339109 YNL172W APC1: Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition MGI:103097 No phenotype data for mouse, yeast is nonessential ORTHOMCL4640: YGR093W, ENSP00000326411 YGR093W : Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus MGI:1919752 No systematic deletion data for yeast, no mouse data ORTHOMCL9417: YJR034W, ENSP00000330730 YJR034W MGI:1923428 No phenotype data for mouse, yeast is essential ORTHOMCL4632: YPL160W, ENSP00000274562 YPL160W CDC60: Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA MGI:1913808 No phenotype data for mouse, yeast is nonessential ORTHOMCL3932: YCR036W, ENSP00000306817 YCR036W RBK1: Putative ribokinase MGI:1918586 Mouse only essential ORTHOMCL1386: YNL259C, ENSP00000316854 YNL259C ATX1: Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake MGI:1333855 Atox1: ATX1 (antioxidant protein 1) homolog 1 (yeast) Mouse only essential ORTHOMCL8419: YJL088W, ENSP00000039007 YJL088W ARG3: Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine MGI:97448 Otc: ornithine transcarbamylase Neither essential ORTHOMCL6156: YBL019W, ENSP00000306132 YBL019W APN2: Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII MGI:1924872 Apex2: apurinic/apyrimidinic endonuclease 2 No phenotype data for mouse, yeast is nonessential ORTHOMCL6555: YOR356W, ENSP00000303552 YOR356W : Hypothetical protein MGI:106100 No phenotype data for mouse, yeast is essential ORTHOMCL3808: YLR175W, ENSP00000253127 YLR175W CBF5: Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), probable rRNA pseudouridine synthase, binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53p MGI:3040698 Mouse only essential ORTHOMCL7426: YMR201C, ENSP00000259463 YMR201C RAD14: Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein MGI:99135 Xpa: xeroderma pigmentosum, complementation group A No phenotype data for mouse, yeast is nonessential ORTHOMCL5601: YMR077C, ENSP00000317468 YMR077C VPS20: Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes MGI:3583942 No phenotype data for mouse, yeast is essential ORTHOMCL4831: YPL126W, ENSP00000314193 YPL126W NAN1: U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA MGI:1920924 No phenotype data for mouse, yeast is essential ORTHOMCL6061: YLR222C, ENSP00000331815 YLR222C UTP13: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA MGI:2384863 No phenotype data for mouse, yeast is essential ORTHOMCL2354: YLL036C, ENSP00000227524 YLL036C PRP19: Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases MGI:106247 No phenotype data for mouse, yeast is essential ORTHOMCL3314: YNL113W, ENSP00000302478 YNL113W RPC19: RNA polymerase subunit, common to RNA polymerases I and III MGI:108403 No phenotype data for mouse, yeast is nonessential ORTHOMCL5855: YOR123C, ENSP00000299601 YOR123C LEO1: Component of the Paf1 complex, which associates with RNA polymerase II and is involved in histone methylation MGI:2685031 No phenotype data for mouse, yeast is essential ORTHOMCL5313: YPR048W, ENSP00000343344 YPR048W TAH18: Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase delta MGI:1926047 No phenotype data for mouse, yeast is nonessential ORTHOMCL3811: YPL109C, ENSP00000072869 YPL109C : Hypothetical protein MGI:1889336 Mouse only essential ORTHOMCL3733: YPL138C, ENSP00000285106 YPL138C SPP1: Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein MGI:1921572 Cxxc1: CXXC finger 1 (PHD domain) No phenotype data for mouse, yeast is nonessential ORTHOMCL6761: YOL125W, ENSP00000241962 YOL125W : Hypothetical protein MGI:1925219 No phenotype data for mouse, yeast is essential ORTHOMCL1942: YBL092W, ENSP00000339064 YBL092W RPL32: Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing MGI:98038 No phenotype data for mouse, yeast is nonessential ORTHOMCL15453: YBR233W, ENSP00000305556 YBR233W PBP2: RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length MGI:1345635 No phenotype data for mouse, yeast is essential ORTHOMCL4578: YDR045C, ENSP00000293860 YDR045C RPC11: RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription MGI:1914255 No phenotype data for mouse, yeast is nonessential ORTHOMCL6739: YLR181C, ENSP00000011652 YLR181C VTA1: Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defects MGI:1913451 No phenotype data for mouse, yeast is nonessential ORTHOMCL2528: YBR227C, ENSP00000300107 YBR227C MCX1: Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteins MGI:1346017 No phenotype data for mouse, yeast is essential ORTHOMCL5391: YEL002C, ENSP00000235894 YEL002C WBP1: Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum MGI:1194508 No systematic deletion data for yeast, no mouse data ORTHOMCL5031: YCR042C, ENSP00000181506 YCR042C MGI:2443028 No phenotype data for mouse, yeast is nonessential ORTHOMCL4188: YGR207C, ENSP00000311930 YGR207C : Protein of unknown function; homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; interacts with frataxin (Yfh1p) MGI:106098 No phenotype data for mouse, yeast is essential ORTHOMCL6744: YNL222W, ENSP00000291386 YNL222W SSU72: Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo MGI:1916241 No phenotype data for mouse, yeast is nonessential ORTHOMCL4835: YJL179W, ENSP00000261813 YJL179W PFD1: Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin MGI:1914449 No phenotype data for mouse, yeast is essential ORTHOMCL3843: YLR291C, ENSP00000266126 YLR291C GCD7: Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression MGI:2145118 No phenotype data for mouse, yeast is nonessential ORTHOMCL11763: YIR029W, ENSP00000252505 YIR029W DAL2: Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation MGI:2136971 Neither essential ORTHOMCL6885: YCR088W, ENSP00000258780 YCR088W ABP1: Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization MGI:700006 Dbnl: drebrin-like No phenotype data for mouse, yeast is nonessential ORTHOMCL3386: YOL093W, ENSP00000273962 YOL093W TRM10: tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs MGI:1920421 No phenotype data for mouse, yeast is nonessential ORTHOMCL729: YNL044W, ENSP00000222008 YNL044W YIP3: Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p MGI:1201692 No phenotype data for mouse, yeast is nonessential ORTHOMCL3074: YOR288C, ENSP00000272227 YOR288C MPD1: Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation MGI:1919103 No phenotype data for mouse, yeast is essential ORTHOMCL5184: YMR131C, ENSP00000253237 YMR131C RRB1: Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p MGI:2141989 No phenotype data for mouse, yeast is nonessential ORTHOMCL2982: YGR173W, ENSP00000225729 YGR173W RBG2: Protein with similarity to mammalian developmentally regulated GTP-binding protein MGI:1342307 No phenotype data for mouse, yeast is essential ORTHOMCL3280: YBR004C, ENSP00000078527 YBR004C GPI18: Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria MGI:2442480 No phenotype data for mouse, yeast is nonessential ORTHOMCL2182: YPL262W, ENSP00000205832 YPL262W FUM1: Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial localization determined by the N-terminal mitochondrial targeting sequence and protein conformation MGI:95530 No phenotype data for mouse, yeast is essential ORTHOMCL6999: YER048W-A, ENSP00000332502 YER048W-A ISD11: Protein required for mitochondrial iron-sulfur cluster biosynthesis MGI:2683538 No phenotype data for mouse, yeast is nonessential ORTHOMCL6216: YBR175W, ENSP00000351446 YBR175W SWD3: Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 MGI:2155884 No phenotype data for mouse, yeast is nonessential ORTHOMCL2270: YBR221C, ENSP00000307241 YBR221C PDB1: E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria MGI:1915513 No systematic deletion data for yeast, no mouse data ORTHOMCL6525: Q0085, ENSP00000354632 Q0085 MGI:99927 No phenotype data for mouse, yeast is essential ORTHOMCL6751: YDL148C, ENSP00000315674 YDL148C NOP14: Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA MGI:1922666 No phenotype data for mouse, yeast is nonessential ORTHOMCL2693: YEL052W, ENSP00000258002 YEL052W AFG1: Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to mitochondria MGI:2148801 No phenotype data for mouse, yeast is nonessential ORTHOMCL4538: YGL127C, ENSP00000225728 YGL127C SOH1: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits MGI:1914529 No phenotype data for mouse, yeast is essential ORTHOMCL4662: YDR472W, ENSP00000316990 YDR472W TRS31: One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic MGI:1913932 No phenotype data for mouse, yeast is essential ORTHOMCL4491: YIL142W, ENSP00000299300 YIL142W CCT2: Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo MGI:107186 No phenotype data for mouse, yeast is nonessential ORTHOMCL4788: YPR004C, ENSP00000267950 YPR004C : Electron transfer flavoprotein complex subunit ETF-alpha; contains a FAD binding domain; interacts with YFH1, the yeast frataxin homolog MGI:106092 Both essential ORTHOMCL6998: YMR043W, ENSP00000265354 YMR043W MCM1: Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes MGI:106658 Srf: serum response factor No phenotype data for mouse, yeast is essential ORTHOMCL3542: YDR311W, ENSP00000265963 YDR311W TFB1: Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators MGI:1277216 No phenotype data for mouse, yeast is essential ORTHOMCL5556: YLR438C-A, ENSP00000302160 YLR438C-A LSM3: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA MGI:1914928 Mouse only essential ORTHOMCL3830: YLR447C, ENSP00000290949 YLR447C VMA6: Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane MGI:1201778 Atp6v0d1: ATPase, H+ transporting, lysosomal V0 subunit D1 Mouse only essential ORTHOMCL6801: YGL153W, ENSP00000270774 YGL153W PEX14: Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery, interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p MGI:1927868 Pex14: peroxisomal biogenesis factor 14 No phenotype data for mouse, yeast is nonessential ORTHOMCL5298: YGR171C, ENSP00000282276 YGR171C MSM1: Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p MGI:2444136 No phenotype data for mouse, yeast is nonessential ORTHOMCL3487: YMR217W, ENSP00000295920 YMR217W GUA1: GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation MGI:2448526 No phenotype data for mouse, yeast is nonessential ORTHOMCL4018: YDR363W-A, ENSP00000248566 YDR363W-A SEM1: Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1 MGI:109238 No phenotype data for mouse, yeast is essential ORTHOMCL4546: YJL014W, ENSP00000295688 YJL014W CCT3: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo MGI:104708 No phenotype data for mouse, yeast is nonessential ORTHOMCL6939: YOR126C, ENSP00000340110 YOR126C IAH1: Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing MGI:1914982 No phenotype data for mouse, yeast is essential ORTHOMCL5074: YBR154C, ENSP00000215587 YBR154C RPB5: RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation MGI:1913670 No phenotype data for mouse, yeast is nonessential ORTHOMCL6493: YPL009C, ENSP00000298310 YPL009C : Hypothetical protein MGI:1918305 No phenotype data for mouse, yeast is nonessential ORTHOMCL1494: YCL001W, ENSP00000302088 YCL001W RER1: Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER MGI:1915080 No phenotype data for mouse, yeast is nonessential ORTHOMCL2810: YDR075W, ENSP00000279387 YDR075W PPH3: Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3p MGI:1891763 No phenotype data for mouse, yeast is nonessential ORTHOMCL4686: YKL188C, ENSP00000263889 YKL188C PXA2: Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins MGI:1349216 No phenotype data for mouse, yeast is essential ORTHOMCL4643: YLR215C, ENSP00000281141 YLR215C CDC123: Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein MGI:2138811 No phenotype data for mouse, yeast is nonessential ORTHOMCL11220: YER044C, ENSP00000256319 YER044C ERG28: Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p MGI:1915571 No phenotype data for mouse, yeast is nonessential ORTHOMCL4917: YFL046W, ENSP00000260054 YFL046W FMP32: The authentic, non-tagged protein was localized to the mitochondria MGI:1913615 No phenotype data for mouse, yeast is nonessential ORTHOMCL4145: YKL216W, ENSP00000219240 YKL216W URA1: Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid MGI:1928378 No