Phenotype data for mouse (downloaded from MGI) and yeast (downloaded from SGD), were used to determined whether one, both, or neither genes are essential in ORTHOMCL families that have unambiguous (1:1:1) otholog families for yeast, mouse, and human.
Counts:
Total # of families with perfect 1:1:1 orthologs: 929 Both (yeast-mouse) essential: 24, only yeast: 4, only mouse: 47, neither: 32 No yeast data: 33, no mouse: 774, bad/deprecated mouse ID: 30
Data file:
essential_yeast_mouse_human.txt: contains all data below in a tab-delimited text file readable by Excel.
| Mouse / yeast phenotypes | OrthoMCL link (Family: Yeast ORF, Human ENSEMBL ID) | Yeast ORF (SGD link) | Yeast gene description | Mouse gene (MGI link) | Mouse gene description |
|---|---|---|---|---|---|
| Both essential | ORTHOMCL1856: YAR007C, ENSP00000254719 | YAR007C | RFA1: Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination | MGI:1915525 | Rpa1: replication protein A1 |
| Both essential | ORTHOMCL3134: YBR136W, ENSP00000343741 | YBR136W | MEC1: Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination | MGI:108028 | Atr: ataxia telangiectasia and Rad3 related |
| Both essential | ORTHOMCL4160: YBR243C, ENSP00000346142 | YBR243C | ALG7: UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin | MGI:1196396 | Dpagt1: dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase) |
| Both essential | ORTHOMCL4378: YDL132W, ENSP00000326804 | YDL132W | CDC53: Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation | MGI:1349658 | Cul1: cullin 1 |
| Both essential | ORTHOMCL3310: YDR047W, ENSP00000246337 | YDR047W | HEM12: Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagents | MGI:98916 | Urod: uroporphyrinogen decarboxylase |
| Both essential | ORTHOMCL4169: YDR167W, ENSP00000299424 | YDR167W | TAF10: Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification | MGI:1346320 | Taf10: TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor |
| Both essential | ORTHOMCL5219: YDR394W, ENSP00000157812 | YDR394W | RPT3: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B | MGI:1346093 | Psmc4: proteasome (prosome, macropain) 26S subunit, ATPase, 4 |
| Both essential | ORTHOMCL4480: YDR460W, ENSP00000261245 | YDR460W | TFB3: Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit | MGI:106207 | Mnat1: menage a trois 1 |
| Both essential | ORTHOMCL5602: YER112W, ENSP00000252816 | YER112W | LSM4: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA | MGI:1354692 | Lsm4: LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) |
| Both essential | ORTHOMCL3526: YER171W, ENSP00000221481 | YER171W | RAD3: 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein | MGI:95413 | Ercc2: excision repair cross-complementing rodent repair deficiency, complementation group 2 |
| Both essential | ORTHOMCL2304: YGL001C, ENSP00000276346 | YGL001C | ERG26: C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis | MGI:1099438 | Nsdhl: NAD(P) dependent steroid dehydrogenase-like |
| Both essential | ORTHOMCL3333: YGR098C, ENSP00000257934 | YGR098C | ESP1: Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibited by Pds1p | MGI:2146156 | Espl1: extra spindle poles-like 1 (S. cerevisiae) |
| Both essential | ORTHOMCL2799: YGR211W, ENSP00000227322 | YGR211W | ZPR1: Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) | MGI:1330262 | Zfp259: zinc finger protein 259 |
| Both essential | ORTHOMCL6931: YHR190W, ENSP00000220584 | YHR190W | ERG9: Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway | MGI:102706 | Fdft1: farnesyl diphosphate farnesyl transferase 1 |
| Both essential | ORTHOMCL3661: YKL125W, ENSP00000198767 | YKL125W | RRN3: Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA | MGI:1925255 | Rrn3: RRN3 RNA polymerase I transcription factor homolog (yeast) |
| Both essential | ORTHOMCL6165: YLR103C, ENSP00000263201 | YLR103C | CDC45: DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes | MGI:1338073 | Cdc45l: cell division cycle 45 homolog (S. cerevisiae)-like |
| Both essential | ORTHOMCL5311: YLR347C, ENSP00000290158 | YLR347C | KAP95: Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complex | MGI:107532 | Kpnb1: karyopherin (importin) beta 1 |
| Both essential | ORTHOMCL6998: YMR043W, ENSP00000265354 | YMR043W | MCM1: Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes | MGI:106658 | Srf: serum response factor |
| Both essential | ORTHOMCL3968: YOR103C, ENSP00000250498 | YOR103C | OST2: Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins | MGI:101912 | Dad1: defender against cell death 1 |
| Both essential | ORTHOMCL3940: YOR117W, ENSP00000298852 | YOR117W | RPT5: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription | MGI:1098754 | Psmc3: proteasome (prosome, macropain) 26S subunit, ATPase 3 |
| Both essential | ORTHOMCL2677: YOR176W, ENSP00000262093 | YOR176W | HEM15: Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; Yfh1p mediates the use of iron by Hem15p | MGI:95513 | Fech: ferrochelatase |
| Both essential | ORTHOMCL5096: YOR261C, ENSP00000219313 | YOR261C | RPN8: Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p | MGI:1351511 | Psmd7: proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 |
| Both essential | ORTHOMCL6782: YOR278W, ENSP00000344508 | YOR278W | HEM4: Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathway | MGI:98917 | Uros: uroporphyrinogen III synthase |
| Both essential | ORTHOMCL4273: YPL175W, ENSP00000297902 | YPL175W | SPT14: UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins | MGI:99461 | Piga: phosphatidylinositol glycan anchor biosynthesis, class A |
| Mouse only essential | ORTHOMCL2822: YAL058W, ENSP00000247461 | YAL058W | CNE1: Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast | MGI:88261 | Canx: calnexin |
| Mouse only essential | ORTHOMCL8072: YBL088C, ENSP00000278616 | YBL088C | TEL1: Protein kinase, primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene | MGI:107202 | Atm: ataxia telangiectasia mutated homolog (human) |
| Mouse only essential | ORTHOMCL16679: YBR023C, ENSP00000306991 | YBR023C | CHS3: Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan | MGI:107821 | Has2: hyaluronan synthase 2 |
| Mouse only essential | ORTHOMCL8947: YBR094W, ENSP00000233336 | YBR094W | : Hypothetical protein | MGI:1916987 | Ttl: tubulin tyrosine ligase |
| Mouse only essential | ORTHOMCL3954: YCL008C, ENSP00000251968 | YCL008C | STP22: Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype | MGI:106581 | Tsg101: tumor susceptibility gene 101 |
| Mouse only essential | ORTHOMCL10198: YCR065W, ENSP00000333188 | YCR065W | HCM1: Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role | MGI:1349428 | Foxl2: forkhead box L2 |
| Mouse only essential | ORTHOMCL5362: YDL090C, ENSP00000246166 | YDL090C | RAM1: Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit | MGI:1861305 | Fntb: farnesyltransferase, CAAX box, beta |
| Mouse only essential | ORTHOMCL4807: YDR027C, ENSP00000272322 | YDR027C | VPS54: Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p | MGI:2178798 | Vps54: vacuolar protein sorting 54 (yeast) |
| Mouse only essential | ORTHOMCL7529: YDR142C, ENSP00000315680 | YDR142C | PEX7: Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) | MGI:1321392 | Pex7: peroxisome biogenesis factor 7 |
| Mouse only essential | ORTHOMCL3584: YDR410C, ENSP00000313340 | YDR410C | STE14: Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane | MGI:1888594 | Icmt: isoprenylcysteine carboxyl methyltransferase |
| Mouse only essential | ORTHOMCL6977: YDR465C, ENSP00000252288 | YDR465C | RMT2: Arginine methyltransferase; ribosomal protein L12 is a substrate | MGI:1098221 | Gamt: guanidinoacetate methyltransferase |
| Mouse only essential | ORTHOMCL2959: YDR486C, ENSP00000223500 | YDR486C | VPS60: Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradation | MGI:1924209 | Chmp5: chromatin modifying protein 5 |
| Mouse only essential | ORTHOMCL12009: YEL009C, ENSP00000252818 | YEL009C | GCN4: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels | MGI:96648 | Jund1: Jun proto-oncogene related gene d1 |
| Mouse only essential | ORTHOMCL3353: YER095W, ENSP00000267868 | YER095W | RAD51: Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein | MGI:97890 | Rad51: RAD51 homolog (S. cerevisiae) |
| Mouse only essential | ORTHOMCL6240: YER107C, ENSP00000217117 | YER107C | GLE2: Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1p | MGI:1913929 | Rae1: RAE1 RNA export 1 homolog (S. pombe) |
| Mouse only essential | ORTHOMCL2761: YFL018C, ENSP00000205402 | YFL018C | LPD1: Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes | MGI:107450 | Dld: dihydrolipoamide dehydrogenase |
| Mouse only essential | ORTHOMCL10610: YFR038W, ENSP00000239027 | YFR038W | IRC5: Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52 foci | MGI:106209 | Hells: helicase, lymphoid specific |
| Mouse only essential | ORTHOMCL6662: YGL043W, ENSP00000353558 | YGL043W | DST1: General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites | MGI:1196624 | Tcea1: transcription elongation factor A (SII) 1 |
| Mouse only essential | ORTHOMCL6801: YGL153W, ENSP00000270774 | YGL153W | PEX14: Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery, interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p | MGI:1927868 | Pex14: peroxisomal biogenesis factor 14 |
| Mouse only essential | ORTHOMCL5579: YGR112W, ENSP00000277404 | YGR112W | SHY1: Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogaster | MGI:98443 | Surf1: surfeit gene 1 |
| Mouse only essential | ORTHOMCL1995: YGR132C, ENSP00000300408 | YGR132C | PHB1: Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation | MGI:97572 | Phb: prohibitin |
| Mouse only essential | ORTHOMCL3265: YIL049W, ENSP00000264228 | YIL049W | DFG10: Protein of unknown function, involved in filamentous growth | MGI:1930252 | Srd5a2l: steroid 5 alpha-reductase 2-like |
| Mouse only essential | ORTHOMCL8419: YJL088W, ENSP00000039007 | YJL088W | ARG3: Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine | MGI:97448 | Otc: ornithine transcarbamylase |
| Mouse only essential | ORTHOMCL5253: YJL208C, ENSP00000300491 | YJL208C | NUC1: Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has a role in mitochondrial recombination | MGI:1261433 | Endog: endonuclease G |
| Mouse only essential | ORTHOMCL5644: YKL113C, ENSP00000305480 | YKL113C | RAD27: 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family | MGI:102779 | Fen1: flap structure specific endonuclease 1 |
| Mouse only essential | ORTHOMCL4990: YKR009C, ENSP00000256216 | YKR009C | FOX2: Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities | MGI:105089 | Hsd17b4: hydroxysteroid (17-beta) dehydrogenase 4 |
| Mouse only essential | ORTHOMCL4051: YLL009C, ENSP00000261070 | YLL009C | COX17: Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase | MGI:1333806 | Cox17: cytochrome c oxidase, subunit XVII assembly protein homolog (yeast) |
| Mouse only essential | ORTHOMCL3830: YLR447C, ENSP00000290949 | YLR447C | VMA6: Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane | MGI:1201778 | Atp6v0d1: ATPase, H+ transporting, lysosomal V0 subunit D1 |
| Mouse only essential | ORTHOMCL1153: YML012W, ENSP00000303145 | YML012W | ERV25: Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport | MGI:1915831 | Tmed10: transmembrane emp24-like trafficking protein 10 (yeast) |
| Mouse only essential | ORTHOMCL4311: YML097C, ENSP00000284957 | YML097C | VPS9: A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin | MGI:1929459 | Rabgef1: RAB guanine nucleotide exchange factor (GEF) 1 |
| Mouse only essential | ORTHOMCL5327: YMR080C, ENSP00000262803 | YMR080C | NAM7: ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenance | MGI:107995 | Upf1: UPF1 regulator of nonsense transcripts homolog (yeast) |
| Mouse only essential | ORTHOMCL6519: YMR154C, ENSP00000253693 | YMR154C | RIM13: Calpain-like protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB | MGI:1338030 | Capn7: calpain 7 |
| Mouse only essential | ORTHOMCL7426: YMR201C, ENSP00000259463 | YMR201C | RAD14: Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein | MGI:99135 | Xpa: xeroderma pigmentosum, complementation group A |
| Mouse only essential | ORTHOMCL4702: YMR234W, ENSP00000313350 | YMR234W | RNH1: Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strand | MGI:1335073 | Rnaseh1: ribonuclease H1 |
| Mouse only essential | ORTHOMCL5136: YMR274C, ENSP00000309163 | YMR274C | RCE1: Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone | MGI:1336895 | Rce1: RCE1 homolog, prenyl protein peptidase (S. cerevisiae) |
| Mouse only essential | ORTHOMCL6271: YNL141W, ENSP00000352331 | YNL141W | AAH1: Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolism | MGI:87916 | Ada: adenosine deaminase |
| Mouse only essential | ORTHOMCL7462: YNL239W, ENSP00000261714 | YNL239W | LAP3: Aminopeptidase of cysteine protease family, has a DNA binding activity and acts as bleomycin hydrolase in vitro; transcription is regulated by galactose via Gal4p | MGI:1345186 | Blmh: bleomycin hydrolase |
| Mouse only essential | ORTHOMCL1386: YNL259C, ENSP00000316854 | YNL259C | ATX1: Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake | MGI:1333855 | Atox1: ATX1 (antioxidant protein 1) homolog 1 (yeast) |
| Mouse only essential | ORTHOMCL5733: YOL031C, ENSP00000265195 | YOL031C | SIL1: Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein | MGI:1932040 | Sil1: endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae) |
| Mouse only essential | ORTHOMCL9550: YOL147C, ENSP00000300056 | YOL147C | PEX11: Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elements | MGI:1338788 | Pex11a: peroxisomal biogenesis factor 11a |
| Mouse only essential | ORTHOMCL3621: YOR196C, ENSP00000261434 | YOR196C | LIP5: Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase | MGI:1934604 | Lias: lipoic acid synthetase |
| Mouse only essential | ORTHOMCL2179: YOR269W, ENSP00000006951 | YOR269W | PAC1: Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1 | MGI:109520 | Pafah1b1: platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit |
| Mouse only essential | ORTHOMCL4274: YPL022W, ENSP00000310520 | YPL022W | RAD1: Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein | MGI:1354163 | Ercc4: excision repair cross-complementing rodent repair deficiency, complementation group 4 |
| Mouse only essential | ORTHOMCL3733: YPL138C, ENSP00000285106 | YPL138C | SPP1: Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein | MGI:1921572 | Cxxc1: CXXC finger 1 (PHD domain) |
| Mouse only essential | ORTHOMCL5197: YPL149W, ENSP00000263322 | YPL149W | ATG5: Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formation | MGI:1277186 | Atg5: autophagy-related 5 (yeast) |
| Mouse only essential | ORTHOMCL4699: YPL227C, ENSP00000239891 | YPL227C | ALG5: UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum | MGI:1913498 | Alg5: asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase) |
| Mouse only essential | ORTHOMCL3076: YPL259C, ENSP00000291439 | YPL259C | APM1: Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting | MGI:102776 | Ap1m1: adaptor-related protein complex AP-1, mu subunit 1 |
| Neither essential | ORTHOMCL6156: YBL019W, ENSP00000306132 | YBL019W | APN2: Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII | MGI:1924872 | Apex2: apurinic/apyrimidinic endonuclease 2 |
| Neither essential | ORTHOMCL2473: YBL064C, ENSP00000236251 | YBL064C | PRX1: Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stress | MGI:894320 | Prdx6: peroxiredoxin 6 |
| Neither essential | ORTHOMCL10670: YBR276C, ENSP00000239223 | YBR276C | PPS1: Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle | MGI:105120 | Dusp1: dual specificity phosphatase 1 |
| Neither essential | ORTHOMCL3323: YCR075C, ENSP00000046640 | YCR075C | ERS1: Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains | MGI:1932872 | Ctns: cystinosis, nephropathic |
| Neither essential | ORTHOMCL6885: YCR088W, ENSP00000258780 | YCR088W | ABP1: Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization | MGI:700006 | Dbnl: drebrin-like |
| Neither essential | ORTHOMCL4391: YDL168W, ENSP00000296412 | YDL168W | SFA1: Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p | MGI:87929 | Adh5: alcohol dehydrogenase 5 (class III), chi polypeptide |
| Neither essential | ORTHOMCL5194: YDR097C, ENSP00000234420 | YDR097C | MSH6: Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p | MGI:1343961 | Msh6: mutS homolog 6 (E. coli) |
| Neither essential | ORTHOMCL6416: YDR159W, ENSP00000291688 | YDR159W | SAC3: Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleus | MGI:1930089 | Mcm3ap: minichromosome maintenance deficient 3 (S. cerevisiae) associated protein |
| Neither essential | ORTHOMCL1098: YDR256C, ENSP00000241052 | YDR256C | CTA1: Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation | MGI:88271 | Cat: catalase |
| Neither essential | ORTHOMCL6374: YDR283C, ENSP00000263791 | YDR283C | GCN2: Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex | MGI:1353427 | Eif2ak4: eukaryotic translation initiation factor 2 alpha kinase 4 |
| Neither essential | ORTHOMCL6522: YDR305C, ENSP00000342087 | YDR305C | HNT2: Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins | MGI:1277947 | Fhit: fragile histidine triad gene |
| Neither essential | ORTHOMCL3127: YDR386W, ENSP00000307853 | YDR386W | MUS81: Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54p | MGI:1918961 | Mus81: MUS81 endonuclease homolog (yeast) |
| Neither essential | ORTHOMCL6492: YDR419W, ENSP00000306591 | YDR419W | RAD30: DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteins | MGI:1891457 | Polh: polymerase (DNA directed), eta (RAD 30 related) |
| Neither essential | ORTHOMCL3744: YER007W, ENSP00000264180 | YER007W | PAC2: Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl | MGI:1917680 | Tbce: tubulin-specific chaperone e |
| Neither essential | ORTHOMCL7626: YER019W, ENSP00000258052 | YER019W | ISC1: Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domain | MGI:1278330 | Smpd2: sphingomyelin phosphodiesterase 2, neutral |
| Neither essential | ORTHOMCL1554: YER042W, ENSP00000313921 | YER042W | MXR1: Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespan | MGI:106916 | Msra: methionine sulfoxide reductase A |
| Neither essential | ORTHOMCL8565: YER179W, ENSP00000216024 | YER179W | DMC1: Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein | MGI:105393 | Dmc1h: disrupted meiotic cDNA 1 homolog |
| Neither essential | ORTHOMCL4130: YFR010W, ENSP00000261601 | YFR010W | UBP6: Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compounds | MGI:1928898 | Usp14: ubiquitin specific peptidase 14 |
| Neither essential | ORTHOMCL10131: YGL033W, ENSP00000253789 | YGL033W | HOP2: Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair | MGI:1098610 | Psmc3ip: proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein |
| Neither essential | ORTHOMCL4567: YGR123C, ENSP00000012443 | YGR123C | PPT1: Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth | MGI:102666 | Ppp5c: protein phosphatase 5, catalytic subunit |
| Neither essential | ORTHOMCL5487: YJL073W, ENSP00000218763 | YJL073W | JEM1: DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 | MGI:107373 | Dnajc3: DnaJ (Hsp40) homolog, subfamily C, member 3 |
| Neither essential | ORTHOMCL6339: YJR117W, ENSP00000196805 | YJR117W | STE24: Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans | MGI:1890508 | Zmpste24: zinc metallopeptidase, STE24 homolog (S. cerevisiae) |
| Neither essential | ORTHOMCL4519: YKL017C, ENSP00000255078 | YKL017C | HCS1: Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities | MGI:99954 | Ighmbp2: immunoglobulin mu binding protein 2 |
| Neither essential | ORTHOMCL5642: YLR216C, ENSP00000303754 | YLR216C | CPR6: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity | MGI:1914988 | Ppid: peptidylprolyl isomerase D (cyclophilin D) |
| Neither essential | ORTHOMCL3547: YLR370C, ENSP00000228825 | YLR370C | ARC18: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches | MGI:1928375 | Arpc3: actin related protein 2/3 complex, subunit 3 |
| Neither essential | ORTHOMCL1439: YLR389C, ENSP00000265986 | YLR389C | STE23: Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family | MGI:96412 | Ide: insulin degrading enzyme |
| Neither essential | ORTHOMCL3732: YLR396C, ENSP00000267199 | YLR396C | VPS33: ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transport | MGI:1924823 | Vps33a: vacuolar protein sorting 33A (yeast) |
| Neither essential | ORTHOMCL4618: YMR167W, ENSP00000231790 | YMR167W | MLH1: Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancer | MGI:101938 | Mlh1: mutL homolog 1 (E. coli) |
| Neither essential | ORTHOMCL2040: YNL045W, ENSP00000228740 | YNL045W | : Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus | MGI:96836 | Lta4h: leukotriene A4 hydrolase |
| Neither essential | ORTHOMCL2628: YOL075C, ENSP00000260645 | YOL075C | : Hypothetical protein | MGI:1351659 | Abcg5: ATP-binding cassette, sub-family G (WHITE), member 5 |
| Neither essential | ORTHOMCL2624: YOL090W, ENSP00000233146 | YOL090W | MSH2: Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP | MGI:101816 | Msh2: mutS homolog 2 (E. coli) |
| Neither essential | ORTHOMCL5220: YPL172C, ENSP00000261643 | YPL172C | COX10: Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders | MGI:1917633 | Cox10: COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast) |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3823: YAL025C, ENSP00000353246 | YAL025C | MAK16: Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for normal concentration of free 60S ribosomal subunits; required for maintenance of M1 satellite double-stranded RNA of the L-A virus | MGI:1915170 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4848: YAL043C, ENSP00000343851 | YAL043C | PTA1: Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII | MGI:1915438 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL10525: YAR008W, ENSP00000305524 | YAR008W | SEN34: Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease | MGI:1913328 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4949: YBL004W, ENSP00000261637 | YBL004W | UTP20: Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA | MGI:1917933 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3909: YBL023C, ENSP00000265056 | YBL023C | MCM2: Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex | MGI:105380 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4367: YBL035C, ENSP00000265465 | YBL035C | POL12: B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation | MGI:99690 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3880: YBL041W, ENSP00000262193 | YBL041W | PRE7: 20S proteasome beta-type subunit | MGI:104884 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3523: YBL074C, ENSP00000313674 | YBL074C | AAR2: Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron | MGI:1915545 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3105: YBL076C, ENSP00000354047 | YBL076C | ILS1: Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A | MGI:2145219 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2818: YBL084C, ENSP00000066544 | YBL084C | CDC27: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition | MGI:102685 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL1942: YBL092W, ENSP00000339064 | YBL092W | RPL32: Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing | MGI:98038 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5090: YBL097W, ENSP00000240423 | YBL097W | BRN1: Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamics | MGI:2444777 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3280: YBR004C, ENSP00000078527 | YBR004C | GPI18: Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria | MGI:2442480 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5047: YBR055C, ENSP00000266079 | YBR055C | PRP6: Splicing factor, component of the U4/U6-U5 snRNP complex | MGI:1922946 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5563: YBR060C, ENSP00000234296 | YBR060C | ORC2: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28p | MGI:1328306 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5390: YBR070C, ENSP00000303404 | YBR070C | ALG14: Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases | MGI:1914039 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4217: YBR079C, ENSP00000263141 | YBR079C | RPG1: Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes | MGI:95301 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4537: YBR080C, ENSP00000225282 | YBR080C | SEC18: ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSF | MGI:104560 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4485: YBR087W, ENSP00000255484 | YBR087W | RFC5: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon | MGI:1916513 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2821: YBR088C, ENSP00000254983 | YBR088C | POL30: Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair | MGI:97503 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5154: YBR102C, ENSP00000353564 | YBR102C | EXO84: Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis | MGI:2142527 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5442: YBR110W, ENSP00000262374 | YBR110W | ALG1: Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog | MGI:2384774 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5036: YBR123C, ENSP00000277434 | YBR123C | TFC1: One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 | MGI:1917489 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5488: YBR142W, ENSP00000328690 | YBR142W | MAK5: Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits | MGI:1351337 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5074: YBR154C, ENSP00000215587 | YBR154C | RPB5: RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation | MGI:1913670 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5953: YBR192W, ENSP00000320688 | YBR192W | RIM2: Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family | MGI:1924909 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4679: YBR247C, ENSP00000230340 | YBR247C | ENP1: Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus | MGI:1858419 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2753: YBR257W, ENSP00000221770 | YBR257W | POP4: Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase P | MGI:1913411 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6448: YCL004W, ENSP00000262764 | YCL004W | PGS1: Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis | MGI:1921701 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5186: YCL017C, ENSP00000262876 | YCL017C | NFS1: Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria | MGI:1316706 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5505: YCL059C, ENSP00000229214 | YCL059C | KRR1: Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit | MGI:1289274 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4585: YCR054C, ENSP00000252934 | YCR054C | CTR86: Essential protein of unknown function | MGI:1859293 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4443: YCR057C, ENSP00000291576 | YCR057C | PWP2: Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis | MGI:1341200 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2732: YCR093W, ENSP00000320949 | YCR093W | CDC39: Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor | MGI:2442402 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5528: YDL004W, ENSP00000215375 | YDL004W | ATP16: Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis | MGI:1913293 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4003: YDL007W, ENSP00000261303 | YDL007W | RPT2: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle | MGI:106054 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3445: YDL015C, ENSP00000215567 | YDL015C | TSC13: Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p | MGI:1915408 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL8268: YDL028C, ENSP00000230510 | YDL028C | MPS1: Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p | MGI:1194921 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6810: YDL029W, ENSP00000260641 | YDL029W | ARP2: Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity | MGI:1913963 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6146: YDL030W, ENSP00000329527 | YDL030W | PRP9: Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex | MGI:1922312 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4429: YDL031W, ENSP00000304072 | YDL031W | DBP10: Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis | MGI:1919240 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4433: YDL060W, ENSP00000301364 | YDL060W | TSR1: Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particles | MGI:2144566 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3199: YDL097C, ENSP00000261712 | YDL097C | RPN6: Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion | MGI:1916327 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5538: YDL098C, ENSP00000274712 | YDL098C | SNU23: Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome | MGI:1913742 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6972: YDL105W, ENSP00000263449 | YDL105W | NSE4: Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complex | MGI:1915122 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3995: YDL111C, ENSP00000265564 | YDL111C | RRP42: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3p | MGI:1913696 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5223: YDL143W, ENSP00000233836 | YDL143W | CCT4: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo | MGI:104689 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2570: YDL147W, ENSP00000348442 | YDL147W | RPN5: Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p | MGI:1914247 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6751: YDL148C, ENSP00000315674 | YDL148C | NOP14: Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA | MGI:1922666 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5519: YDL205C, ENSP00000278715 | YDL205C | HEM3: Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p | MGI:96112 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4730: YDL208W, ENSP00000274606 | YDL208W | NHP2: Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing | MGI:1098547 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4836: YDL217C, ENSP00000320236 | YDL217C | TIM22: Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membrane | MGI:1929742 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6636: YDR013W, ENSP00000262460 | YDR013W | PSF1: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery | MGI:1916520 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3804: YDR021W, ENSP00000269349 | YDR021W | FAL1: Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases | MGI:1923731 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3551: YDR044W, ENSP00000264193 | YDR044W | HEM13: Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) | MGI:104841 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4578: YDR045C, ENSP00000293860 | YDR045C | RPC11: RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription | MGI:1914255 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5246: YDR054C, ENSP00000263228 | YDR054C | CDC34: Ubiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p, Cdc53p, and an F-box protein, forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradation | MGI:1914865 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5731: YDR060W, ENSP00000234170 | YDR060W | MAK21: Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein | MGI:109386 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3041: YDR062W, ENSP00000216484 | YDR062W | LCB2: Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine | MGI:108074 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL13066: YDR081C, ENSP00000355162 | YDR081C | PDC2: Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genes | MGI:2685264 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2921: YDR088C, ENSP00000297151 | YDR088C | SLU7: RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain | MGI:2385598 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3687: YDR091C, ENSP00000296577 | YDR091C | RLI1: Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPase | MGI:1195458 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL13063: YDR164C, ENSP00000221283 | YDR164C | SEC1: Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function | MGI:107370 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL8088: YDR168W, ENSP00000222005 | YDR168W | CDC37: Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle | MGI:109531 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4248: YDR177W, ENSP00000261427 | YDR177W | UBC1: Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response | MGI:1858216 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5069: YDR190C, ENSP00000318297 | YDR190C | RVB1: Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein family | MGI:1928760 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4465: YDR196C, ENSP00000341504 | YDR196C | : predicted to catalyze the final step in synthesis of Coenzyme A | MGI:1915337 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4142: YDR212W, ENSP00000239585 | YDR212W | TCP1: Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptide | MGI:98535 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2286: YDR228C, ENSP00000298281 | YDR228C | PCF11: mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p) | MGI:1919579 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5414: YDR236C, ENSP00000257452 | YDR236C | FMN1: Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane | MGI:1914688 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3599: YDR238C, ENSP00000249923 | YDR238C | SEC26: Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) | MGI:1917599 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5515: YDR246W, ENSP00000351896 | YDR246W | TRS23: One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 | MGI:1926211 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3077: YDR267C, ENSP00000272402 | YDR267C | CIA1: Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteins | MGI:1346998 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2926: YDR280W, ENSP00000243498 | YDR280W | RRP45: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex | MGI:1355319 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL7867: YDR302W, ENSP00000281382 | YDR302W | GPI11: ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog | MGI:99462 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3542: YDR311W, ENSP00000265963 | YDR311W | TFB1: Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators | MGI:1277216 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3447: YDR325W, ENSP00000251496 | YDR325W | YCG1: Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complex | MGI:1930197 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL314: YDR328C, ENSP00000231487 | YDR328C | SKP1: Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase | MGI:103575 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4427: YDR365C, ENSP00000202816 | YDR365C | ESF1: Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels | MGI:1913830 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4733: YDR376W, ENSP00000293195 | YDR376W | ARH1: Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability | MGI:104724 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4560: YDR390C, ENSP00000246548 | YDR390C | UBA2: Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability | MGI:1858313 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3627: YDR397C, ENSP00000236164 | YDR397C | NCB2: Beta subunit of the NC2 dimeric histone-fold complex; represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB; homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2) | MGI:1100515 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5869: YDR398W, ENSP00000296126 | YDR398W | UTP5: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA | MGI:1919765 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL4257: YDR404C, ENSP00000301788 | YDR404C | RPB7: RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p | MGI:1914960 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL2585: YDR427W, ENSP00000333811 | YDR427W | RPN9: Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects | MGI:1345192 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL5360: YDR434W, ENSP00000309430 | YDR434W | GPI17: Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog | MGI:2687325 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL6236: YDR449C, ENSP00000261708 | YDR449C | UTP6: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA | MGI:2445193 | |
| No systematic deletion data for mouse, yeast is essential | ORTHOMCL3681: YDR454C, ENSP00000317659 | YDR454C | GUK1: Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins | MGI:95871 | |
| No systematic deletion data for mouse, yeast is essential |