Conservation of essential genes

Phenotype data for mouse (downloaded from MGI) and yeast (downloaded from SGD), were used to determined whether one, both, or neither genes are essential in ORTHOMCL families that have unambiguous (1:1:1) otholog families for yeast, mouse, and human.

Counts:

Total # of families with perfect 1:1:1 orthologs: 929
Both (yeast-mouse) essential: 24, only yeast: 4, only mouse: 47, neither: 32
No yeast data: 33, no mouse: 774, bad/deprecated mouse ID: 30

Data file:

essential_yeast_mouse_human.txt: contains all data below in a tab-delimited text file readable by Excel.

Mouse / yeast phenotypesOrthoMCL link (Family: Yeast ORF, Human ENSEMBL ID)Yeast ORF (SGD link)Yeast gene descriptionMouse gene (MGI link) Mouse gene description
Both essentialORTHOMCL1856: YAR007C, ENSP00000254719 YAR007CRFA1: Subunit of heterotrimeric Replication Factor A (RF-A), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombinationMGI:1915525Rpa1: replication protein A1  
Both essentialORTHOMCL3134: YBR136W, ENSP00000343741 YBR136WMEC1: Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombinationMGI:108028Atr: ataxia telangiectasia and Rad3 related  
Both essentialORTHOMCL4160: YBR243C, ENSP00000346142 YBR243CALG7: UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycinMGI:1196396Dpagt1: dolichyl-phosphate (UDP-N-acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc-1-P transferase)  
Both essentialORTHOMCL4378: YDL132W, ENSP00000326804 YDL132WCDC53: Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradationMGI:1349658Cul1: cullin 1  
Both essentialORTHOMCL3310: YDR047W, ENSP00000246337 YDR047WHEM12: Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; activity inhibited by Cu2+, Zn2+, Fe2+, Fe3+ and sulfhydryl-specific reagentsMGI:98916Urod: uroporphyrinogen decarboxylase  
Both essentialORTHOMCL4169: YDR167W, ENSP00000299424 YDR167WTAF10: Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modificationMGI:1346320Taf10: TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor  
Both essentialORTHOMCL5219: YDR394W, ENSP00000157812 YDR394WRPT3: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase BMGI:1346093Psmc4: proteasome (prosome, macropain) 26S subunit, ATPase, 4  
Both essentialORTHOMCL4480: YDR460W, ENSP00000261245 YDR460WTFB3: Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunitMGI:106207Mnat1: menage a trois 1  
Both essentialORTHOMCL5602: YER112W, ENSP00000252816 YER112WLSM4: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNAMGI:1354692Lsm4: LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)  
Both essentialORTHOMCL3526: YER171W, ENSP00000221481 YER171WRAD3: 5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polymerase II transcription initiation factor TFIIH; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD proteinMGI:95413Ercc2: excision repair cross-complementing rodent repair deficiency, complementation group 2  
Both essentialORTHOMCL2304: YGL001C, ENSP00000276346 YGL001CERG26: C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesisMGI:1099438Nsdhl: NAD(P) dependent steroid dehydrogenase-like  
Both essentialORTHOMCL3333: YGR098C, ENSP00000257934 YGR098CESP1: Separase with cysteine protease activity (related to caspases) that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibited by Pds1pMGI:2146156Espl1: extra spindle poles-like 1 (S. cerevisiae)  
Both essentialORTHOMCL2799: YGR211W, ENSP00000227322 YGR211WZPR1: Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p)MGI:1330262Zfp259: zinc finger protein 259  
Both essentialORTHOMCL6931: YHR190W, ENSP00000220584 YHR190WERG9: Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathwayMGI:102706Fdft1: farnesyl diphosphate farnesyl transferase 1  
Both essentialORTHOMCL3661: YKL125W, ENSP00000198767 YKL125WRRN3: Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNAMGI:1925255Rrn3: RRN3 RNA polymerase I transcription factor homolog (yeast)  
Both essentialORTHOMCL6165: YLR103C, ENSP00000263201 YLR103CCDC45: DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromesMGI:1338073Cdc45l: cell division cycle 45 homolog (S. cerevisiae)-like  
Both essentialORTHOMCL5311: YLR347C, ENSP00000290158 YLR347CKAP95: Karyopherin beta, forms a dimeric complex with Srp1p (Kap60p) that mediates nuclear import of cargo proteins via a nuclear localization signal (NLS), interacts with nucleoporins to guide transport across the nuclear pore complexMGI:107532Kpnb1: karyopherin (importin) beta 1  
Both essentialORTHOMCL6998: YMR043W, ENSP00000265354 YMR043WMCM1: Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexesMGI:106658Srf: serum response factor  
Both essentialORTHOMCL3968: YOR103C, ENSP00000250498 YOR103COST2: Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteinsMGI:101912Dad1: defender against cell death 1  
Both essentialORTHOMCL3940: YOR117W, ENSP00000298852 YOR117WRPT5: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcriptionMGI:1098754Psmc3: proteasome (prosome, macropain) 26S subunit, ATPase 3  
Both essentialORTHOMCL2677: YOR176W, ENSP00000262093 YOR176WHEM15: Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway; Yfh1p mediates the use of iron by Hem15pMGI:95513Fech: ferrochelatase  
Both essentialORTHOMCL5096: YOR261C, ENSP00000219313 YOR261CRPN8: Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11pMGI:1351511Psmd7: proteasome (prosome, macropain) 26S subunit, non-ATPase, 7  
Both essentialORTHOMCL6782: YOR278W, ENSP00000344508 YOR278WHEM4: Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in the heme biosynthetic pathwayMGI:98917Uros: uroporphyrinogen III synthase  
Both essentialORTHOMCL4273: YPL175W, ENSP00000297902 YPL175WSPT14: UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteinsMGI:99461Piga: phosphatidylinositol glycan anchor biosynthesis, class A  
Mouse only essentialORTHOMCL2822: YAL058W, ENSP00000247461YAL058WCNE1: Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeastMGI:88261Canx: calnexin  
Mouse only essentialORTHOMCL8072: YBL088C, ENSP00000278616YBL088CTEL1: Protein kinase, primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) geneMGI:107202Atm: ataxia telangiectasia mutated homolog (human)  
Mouse only essentialORTHOMCL16679: YBR023C, ENSP00000306991YBR023CCHS3: Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosanMGI:107821Has2: hyaluronan synthase 2  
Mouse only essentialORTHOMCL8947: YBR094W, ENSP00000233336YBR094W: Hypothetical proteinMGI:1916987Ttl: tubulin tyrosine ligase  
Mouse only essentialORTHOMCL3954: YCL008C, ENSP00000251968YCL008CSTP22: Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotypeMGI:106581Tsg101: tumor susceptibility gene 101  
Mouse only essentialORTHOMCL10198: YCR065W, ENSP00000333188YCR065WHCM1: Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance roleMGI:1349428Foxl2: forkhead box L2  
Mouse only essentialORTHOMCL5362: YDL090C, ENSP00000246166YDL090CRAM1: Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunitMGI:1861305Fntb: farnesyltransferase, CAAX box, beta  
Mouse only essentialORTHOMCL4807: YDR027C, ENSP00000272322YDR027CVPS54: Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28pMGI:2178798Vps54: vacuolar protein sorting 54 (yeast)  
Mouse only essentialORTHOMCL7529: YDR142C, ENSP00000315680YDR142CPEX7: Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)MGI:1321392Pex7: peroxisome biogenesis factor 7  
Mouse only essentialORTHOMCL3584: YDR410C, ENSP00000313340YDR410CSTE14: Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane MGI:1888594Icmt: isoprenylcysteine carboxyl methyltransferase  
Mouse only essentialORTHOMCL6977: YDR465C, ENSP00000252288YDR465CRMT2: Arginine methyltransferase; ribosomal protein L12 is a substrateMGI:1098221Gamt: guanidinoacetate methyltransferase  
Mouse only essentialORTHOMCL2959: YDR486C, ENSP00000223500YDR486CVPS60: Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting specific cargo proteins for degradationMGI:1924209Chmp5: chromatin modifying protein 5  
Mouse only essentialORTHOMCL12009: YEL009C, ENSP00000252818YEL009CGCN4: Transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levelsMGI:96648Jund1: Jun proto-oncogene related gene d1  
Mouse only essentialORTHOMCL3353: YER095W, ENSP00000267868YER095WRAD51: Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA proteinMGI:97890Rad51: RAD51 homolog (S. cerevisiae)  
Mouse only essentialORTHOMCL6240: YER107C, ENSP00000217117YER107CGLE2: Component of the nuclear pore complex required for polyadenylated RNA export but not for protein import, homologous to S. pombe Rae1pMGI:1913929Rae1: RAE1 RNA export 1 homolog (S. pombe)  
Mouse only essentialORTHOMCL2761: YFL018C, ENSP00000205402YFL018CLPD1: Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexesMGI:107450Dld: dihydrolipoamide dehydrogenase  
Mouse only essentialORTHOMCL10610: YFR038W, ENSP00000239027YFR038WIRC5: Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52 fociMGI:106209Hells: helicase, lymphoid specific  
Mouse only essentialORTHOMCL6662: YGL043W, ENSP00000353558YGL043WDST1: General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sitesMGI:1196624Tcea1: transcription elongation factor A (SII) 1  
Mouse only essentialORTHOMCL6801: YGL153W, ENSP00000270774YGL153WPEX14: Peroxisomal membrane protein that is a central component of the peroxisomal protein import machinery, interacts with PTS1 (Pex5p) and PTS2 (Pex7p) peroxisomal matrix protein signal recognition factors and membrane receptor Pex13pMGI:1927868Pex14: peroxisomal biogenesis factor 14  
Mouse only essentialORTHOMCL5579: YGR112W, ENSP00000277404YGR112WSHY1: Mitochondrial inner membrane protein required for normal respiration, possible chaperone involved in assembly of cytochrome c oxidase; similar to SURF1 from mammals, chickens, and D. melanogasterMGI:98443Surf1: surfeit gene 1  
Mouse only essentialORTHOMCL1995: YGR132C, ENSP00000300408YGR132CPHB1: Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregationMGI:97572Phb: prohibitin  
Mouse only essentialORTHOMCL3265: YIL049W, ENSP00000264228YIL049WDFG10: Protein of unknown function, involved in filamentous growthMGI:1930252Srd5a2l: steroid 5 alpha-reductase 2-like  
Mouse only essentialORTHOMCL8419: YJL088W, ENSP00000039007YJL088WARG3: Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithineMGI:97448Otc: ornithine transcarbamylase  
Mouse only essentialORTHOMCL5253: YJL208C, ENSP00000300491YJL208CNUC1: Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has a role in mitochondrial recombinationMGI:1261433Endog: endonuclease G  
Mouse only essentialORTHOMCL5644: YKL113C, ENSP00000305480YKL113CRAD27: 5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 familyMGI:102779Fen1: flap structure specific endonuclease 1  
Mouse only essentialORTHOMCL4990: YKR009C, ENSP00000256216YKR009CFOX2: Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activitiesMGI:105089Hsd17b4: hydroxysteroid (17-beta) dehydrogenase 4  
Mouse only essentialORTHOMCL4051: YLL009C, ENSP00000261070YLL009CCOX17: Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidaseMGI:1333806Cox17: cytochrome c oxidase, subunit XVII assembly protein homolog (yeast)  
Mouse only essentialORTHOMCL3830: YLR447C, ENSP00000290949YLR447CVMA6: Subunit D of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membraneMGI:1201778Atp6v0d1: ATPase, H+ transporting, lysosomal V0 subunit D1  
Mouse only essentialORTHOMCL1153: YML012W, ENSP00000303145YML012WERV25: Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transportMGI:1915831Tmed10: transmembrane emp24-like trafficking protein 10 (yeast)  
Mouse only essentialORTHOMCL4311: YML097C, ENSP00000284957YML097CVPS9: A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitinMGI:1929459Rabgef1: RAB guanine nucleotide exchange factor (GEF) 1  
Mouse only essentialORTHOMCL5327: YMR080C, ENSP00000262803YMR080CNAM7: ATP-dependent RNA helicase of the SFI superfamily, required for nonsense mediated mRNA decay and for efficient translation termination at nonsense codons; involved in telomere maintenanceMGI:107995Upf1: UPF1 regulator of nonsense transcripts homolog (yeast)  
Mouse only essentialORTHOMCL6519: YMR154C, ENSP00000253693YMR154CRIM13: Calpain-like protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palBMGI:1338030Capn7: calpain 7  
Mouse only essentialORTHOMCL7426: YMR201C, ENSP00000259463YMR201CRAD14: Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA proteinMGI:99135Xpa: xeroderma pigmentosum, complementation group A  
Mouse only essentialORTHOMCL4702: YMR234W, ENSP00000313350YMR234WRNH1: Ribonuclease H1, removes RNA primers during Okazaki fragment synthesis; degrades RNA attached to the 5'-end of a DNA strandMGI:1335073Rnaseh1: ribonuclease H1  
Mouse only essentialORTHOMCL5136: YMR274C, ENSP00000309163YMR274CRCE1: Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromoneMGI:1336895Rce1: RCE1 homolog, prenyl protein peptidase (S. cerevisiae)  
Mouse only essentialORTHOMCL6271: YNL141W, ENSP00000352331YNL141WAAH1: Adenine deaminase (adenine aminohydrolase), involved in purine salvage and nitrogen catabolismMGI:87916Ada: adenosine deaminase  
Mouse only essentialORTHOMCL7462: YNL239W, ENSP00000261714YNL239WLAP3: Aminopeptidase of cysteine protease family, has a DNA binding activity and acts as bleomycin hydrolase in vitro; transcription is regulated by galactose via Gal4pMGI:1345186Blmh: bleomycin hydrolase  
Mouse only essentialORTHOMCL1386: YNL259C, ENSP00000316854YNL259CATX1: Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptakeMGI:1333855Atox1: ATX1 (antioxidant protein 1) homolog 1 (yeast)  
Mouse only essentialORTHOMCL5733: YOL031C, ENSP00000265195YOL031CSIL1: Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like proteinMGI:1932040Sil1: endoplasmic reticulum chaperone SIL1 homolog (S. cerevisiae)  
Mouse only essentialORTHOMCL9550: YOL147C, ENSP00000300056YOL147CPEX11: Peroxisomal membrane protein required for peroxisome proliferation and medium-chain fatty acid oxidation, most abundant protein in the peroxisomal membrane, regulated by Adr1p and Pip2p-Oaf1p, promoter contains ORE and UAS1-like elementsMGI:1338788Pex11a: peroxisomal biogenesis factor 11a  
Mouse only essentialORTHOMCL3621: YOR196C, ENSP00000261434YOR196CLIP5: Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthaseMGI:1934604Lias: lipoic acid synthetase  
Mouse only essentialORTHOMCL2179: YOR269W, ENSP00000006951YOR269WPAC1: Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1MGI:109520Pafah1b1: platelet-activating factor acetylhydrolase, isoform 1b, beta1 subunit  
Mouse only essentialORTHOMCL4274: YPL022W, ENSP00000310520YPL022WRAD1: Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF proteinMGI:1354163Ercc4: excision repair cross-complementing rodent repair deficiency, complementation group 4  
Mouse only essentialORTHOMCL3733: YPL138C, ENSP00000285106YPL138CSPP1: Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding proteinMGI:1921572Cxxc1: CXXC finger 1 (PHD domain)  
Mouse only essentialORTHOMCL5197: YPL149W, ENSP00000263322YPL149WATG5: Conserved autophagy-related protein that undergoes conjugation with Atg12p and then associates with Atg16p to form a cytosolic complex essential for autophagosome formationMGI:1277186Atg5: autophagy-related 5 (yeast)  
Mouse only essentialORTHOMCL4699: YPL227C, ENSP00000239891YPL227CALG5: UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulumMGI:1913498Alg5: asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)  
Mouse only essentialORTHOMCL3076: YPL259C, ENSP00000291439YPL259CAPM1: Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sortingMGI:102776Ap1m1: adaptor-related protein complex AP-1, mu subunit 1  
Neither essentialORTHOMCL6156: YBL019W, ENSP00000306132YBL019WAPN2: Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIIIMGI:1924872Apex2: apurinic/apyrimidinic endonuclease 2  
Neither essentialORTHOMCL2473: YBL064C, ENSP00000236251YBL064CPRX1: Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; induced during respiratory growth and under conditions of oxidative stressMGI:894320Prdx6: peroxiredoxin 6  
Neither essentialORTHOMCL10670: YBR276C, ENSP00000239223YBR276CPPS1: Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycleMGI:105120Dusp1: dual specificity phosphatase 1  
Neither essentialORTHOMCL3323: YCR075C, ENSP00000046640YCR075CERS1: Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domainsMGI:1932872Ctns: cystinosis, nephropathic  
Neither essentialORTHOMCL6885: YCR088W, ENSP00000258780YCR088WABP1: Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organizationMGI:700006Dbnl: drebrin-like  
Neither essentialORTHOMCL4391: YDL168W, ENSP00000296412YDL168WSFA1: Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1pMGI:87929Adh5: alcohol dehydrogenase 5 (class III), chi polypeptide  
Neither essentialORTHOMCL5194: YDR097C, ENSP00000234420YDR097CMSH6: Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28pMGI:1343961Msh6: mutS homolog 6 (E. coli)  
Neither essentialORTHOMCL6416: YDR159W, ENSP00000291688YDR159WSAC3: Nuclear pore-associated protein, forms a complex with Thp1p that is involved in transcription and in mRNA export from the nucleusMGI:1930089Mcm3ap: minichromosome maintenance deficient 3 (S. cerevisiae) associated protein  
Neither essentialORTHOMCL1098: YDR256C, ENSP00000241052YDR256CCTA1: Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidationMGI:88271Cat: catalase  
Neither essentialORTHOMCL6374: YDR283C, ENSP00000263791YDR283CGCN2: Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complexMGI:1353427Eif2ak4: eukaryotic translation initiation factor 2 alpha kinase 4  
Neither essentialORTHOMCL6522: YDR305C, ENSP00000342087YDR305CHNT2: Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteinsMGI:1277947Fhit: fragile histidine triad gene  
Neither essentialORTHOMCL3127: YDR386W, ENSP00000307853YDR386WMUS81: Helix-hairpin-helix protein, involved in DNA repair and replication fork stability; functions as an endonuclease in complex with Mms4p; interacts with Rad54pMGI:1918961Mus81: MUS81 endonuclease homolog (yeast)  
Neither essentialORTHOMCL6492: YDR419W, ENSP00000306591YDR419WRAD30: DNA polymerase eta, involved in the predominantly error-free bypass replication of DNA lesions, catalyzes the efficient and accurate synthesis of DNA opposite cyclobutane pyrimidine dimers; homolog of human POLH and bacterial DinB proteinsMGI:1891457Polh: polymerase (DNA directed), eta (RAD 30 related)  
Neither essentialORTHOMCL3744: YER007W, ENSP00000264180YER007WPAC2: Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomylMGI:1917680Tbce: tubulin-specific chaperone e  
Neither essentialORTHOMCL7626: YER019W, ENSP00000258052YER019WISC1: Inositol phosphosphingolipid phospholipase C, hydrolyzes inositolphosphosphingolipids, activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol, mediates Na+ and Li+ halotolerance, contains a P loop-like domainMGI:1278330Smpd2: sphingomyelin phosphodiesterase 2, neutral  
Neither essentialORTHOMCL1554: YER042W, ENSP00000313921YER042WMXR1: Peptide methionine sulfoxide reductase, reverses the oxidation of methionine residues; involved in oxidative damage repair, providing resistance to oxidative stress and regulation of lifespanMGI:106916Msra: methionine sulfoxide reductase A  
Neither essentialORTHOMCL8565: YER179W, ENSP00000216024YER179WDMC1: Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA proteinMGI:105393Dmc1h: disrupted meiotic cDNA 1 homolog  
Neither essentialORTHOMCL4130: YFR010W, ENSP00000261601YFR010WUBP6: Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; deletion causes hypersensitivity to cycloheximide and other toxic compoundsMGI:1928898Usp14: ubiquitin specific peptidase 14  
Neither essentialORTHOMCL10131: YGL033W, ENSP00000253789YGL033WHOP2: Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repairMGI:1098610Psmc3ip: proteasome (prosome, macropain) 26S subunit, ATPase 3, interacting protein  
Neither essentialORTHOMCL4567: YGR123C, ENSP00000012443YGR123CPPT1: Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growthMGI:102666Ppp5c: protein phosphatase 5, catalytic subunit  
Neither essentialORTHOMCL5487: YJL073W, ENSP00000218763YJL073WJEM1: DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2MGI:107373Dnajc3: DnaJ (Hsp40) homolog, subfamily C, member 3  
Neither essentialORTHOMCL6339: YJR117W, ENSP00000196805YJR117WSTE24: Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spansMGI:1890508Zmpste24: zinc metallopeptidase, STE24 homolog (S. cerevisiae)  
Neither essentialORTHOMCL4519: YKL017C, ENSP00000255078YKL017CHCS1: Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activitiesMGI:99954Ighmbp2: immunoglobulin mu binding protein 2  
Neither essentialORTHOMCL5642: YLR216C, ENSP00000303754YLR216CCPR6: Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activityMGI:1914988Ppid: peptidylprolyl isomerase D (cyclophilin D)  
Neither essentialORTHOMCL3547: YLR370C, ENSP00000228825YLR370CARC18: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patchesMGI:1928375Arpc3: actin related protein 2/3 complex, subunit 3  
Neither essentialORTHOMCL1439: YLR389C, ENSP00000265986YLR389CSTE23: Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme familyMGI:96412Ide: insulin degrading enzyme  
Neither essentialORTHOMCL3732: YLR396C, ENSP00000267199YLR396CVPS33: ATP-binding protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at both the Golgi-to-endosome and endosome-to-vacuole stages of protein transportMGI:1924823Vps33a: vacuolar protein sorting 33A (yeast)  
Neither essentialORTHOMCL4618: YMR167W, ENSP00000231790YMR167WMLH1: Protein required for mismatch repair in mitosis and meiosis, postmeiotic segregation, and spore viability; forms a complex with Pms1p and Msh2p to repair mismatched DNA; human homolog is associated with hereditary non-polyposis colon cancerMGI:101938Mlh1: mutL homolog 1 (E. coli)  
Neither essentialORTHOMCL2040: YNL045W, ENSP00000228740YNL045W: Leucyl aminopeptidase (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; role in vivo is not defined; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleusMGI:96836Lta4h: leukotriene A4 hydrolase  
Neither essentialORTHOMCL2628: YOL075C, ENSP00000260645YOL075C: Hypothetical proteinMGI:1351659Abcg5: ATP-binding cassette, sub-family G (WHITE), member 5  
Neither essentialORTHOMCL2624: YOL090W, ENSP00000233146YOL090WMSH2: Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATPMGI:101816Msh2: mutS homolog 2 (E. coli)  
Neither essentialORTHOMCL5220: YPL172C, ENSP00000261643YPL172CCOX10: Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disordersMGI:1917633Cox10: COX10 homolog, cytochrome c oxidase assembly protein, heme A: farnesyltransferase (yeast)  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3823: YAL025C, ENSP00000353246YAL025CMAK16: Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for normal concentration of free 60S ribosomal subunits; required for maintenance of M1 satellite double-stranded RNA of the L-A virusMGI:1915170  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4848: YAL043C, ENSP00000343851YAL043CPTA1: Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPIIMGI:1915438  
No systematic deletion data for mouse, yeast is essentialORTHOMCL10525: YAR008W, ENSP00000305524YAR008WSEN34: Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonucleaseMGI:1913328  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4949: YBL004W, ENSP00000261637YBL004WUTP20: Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNAMGI:1917933  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3909: YBL023C, ENSP00000265056YBL023CMCM2: Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexMGI:105380  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4367: YBL035C, ENSP00000265465YBL035CPOL12: B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulationMGI:99690  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3880: YBL041W, ENSP00000262193YBL041WPRE7: 20S proteasome beta-type subunitMGI:104884  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3523: YBL074C, ENSP00000313674YBL074CAAR2: Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistronMGI:1915545  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3105: YBL076C, ENSP00000354047YBL076CILS1: Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin AMGI:2145219  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2818: YBL084C, ENSP00000066544YBL084CCDC27: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionMGI:102685  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1942: YBL092W, ENSP00000339064YBL092WRPL32: Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencingMGI:98038  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5090: YBL097W, ENSP00000240423YBL097WBRN1: Essential protein required for chromosome condensation, likely to function as an intrinsic component of the condensation machinery, may influence multiple aspects of chromosome transmission and dynamicsMGI:2444777  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3280: YBR004C, ENSP00000078527YBR004CGPI18: Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondriaMGI:2442480  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5047: YBR055C, ENSP00000266079YBR055CPRP6: Splicing factor, component of the U4/U6-U5 snRNP complexMGI:1922946  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5563: YBR060C, ENSP00000234296YBR060CORC2: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; may be phosphorylated by Cdc28pMGI:1328306  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5390: YBR070C, ENSP00000303404YBR070CALG14: Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferasesMGI:1914039  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4217: YBR079C, ENSP00000263141YBR079CRPG1: Subunit of the core complex of translation initiation factor 3(eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomesMGI:95301  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4537: YBR080C, ENSP00000225282YBR080CSEC18: ATPase required for the release of Sec17p during the 'priming' step in homotypic vacuole fusion and for ER to Golgi transport; homolog of the mammalian NSFMGI:104560  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4485: YBR087W, ENSP00000255484YBR087WRFC5: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonMGI:1916513  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2821: YBR088C, ENSP00000254983YBR088CPOL30: Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repairMGI:97503  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5154: YBR102C, ENSP00000353564YBR102CEXO84: Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosisMGI:2142527  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5442: YBR110W, ENSP00000262374YBR110WALG1: Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human orthologMGI:2384774  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5036: YBR123C, ENSP00000277434YBR123CTFC1: One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63MGI:1917489  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5488: YBR142W, ENSP00000328690YBR142WMAK5: Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunitsMGI:1351337  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5074: YBR154C, ENSP00000215587YBR154CRPB5: RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivationMGI:1913670  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5953: YBR192W, ENSP00000320688YBR192WRIM2: Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier familyMGI:1924909  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4679: YBR247C, ENSP00000230340YBR247CENP1: Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolusMGI:1858419  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2753: YBR257W, ENSP00000221770YBR257WPOP4: Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends; binds to the RPR1 RNA subunit in Rnase PMGI:1913411  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6448: YCL004W, ENSP00000262764YCL004WPGS1: Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesisMGI:1921701  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5186: YCL017C, ENSP00000262876YCL017CNFS1: Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis; required for the post-transcriptional thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondriaMGI:1316706  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5505: YCL059C, ENSP00000229214YCL059CKRR1: Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunitMGI:1289274  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4585: YCR054C, ENSP00000252934YCR054CCTR86: Essential protein of unknown functionMGI:1859293  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4443: YCR057C, ENSP00000291576YCR057CPWP2: Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesisMGI:1341200  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2732: YCR093W, ENSP00000320949YCR093WCDC39: Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factorMGI:2442402  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5528: YDL004W, ENSP00000215375YDL004WATP16: Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesisMGI:1913293  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4003: YDL007W, ENSP00000261303YDL007WRPT2: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particleMGI:106054  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3445: YDL015C, ENSP00000215567YDL015CTSC13: Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4pMGI:1915408  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8268: YDL028C, ENSP00000230510YDL028CMPS1: Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1pMGI:1194921  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6810: YDL029W, ENSP00000260641YDL029WARP2: Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarityMGI:1913963  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6146: YDL030W, ENSP00000329527YDL030WPRP9: Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complexMGI:1922312  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4429: YDL031W, ENSP00000304072YDL031WDBP10: Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesisMGI:1919240  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4433: YDL060W, ENSP00000301364YDL060WTSR1: Protein required for processing of 20S pre-rRNA in the cytoplasm, associates with pre-40S ribosomal particlesMGI:2144566  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3199: YDL097C, ENSP00000261712YDL097CRPN6: Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletionMGI:1916327  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5538: YDL098C, ENSP00000274712YDL098CSNU23: Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosomeMGI:1913742  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6972: YDL105W, ENSP00000263449YDL105WNSE4: Nuclear protein that plays a role in the function of the Smc5p-Rhc18p complexMGI:1915122  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3995: YDL111C, ENSP00000265564YDL111CRRP42: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp4p, Rrp41p, Rrp43p and Dis3pMGI:1913696  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5223: YDL143W, ENSP00000233836YDL143WCCT4: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoMGI:104689  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2570: YDL147W, ENSP00000348442YDL147WRPN5: Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7pMGI:1914247  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6751: YDL148C, ENSP00000315674YDL148CNOP14: Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNAMGI:1922666  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5519: YDL205C, ENSP00000278715YDL205CHEM3: Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3pMGI:96112  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4730: YDL208W, ENSP00000274606YDL208WNHP2: Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processingMGI:1098547  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4836: YDL217C, ENSP00000320236YDL217CTIM22: Component of the mitochondrial Tim54p-Tim22p complex involved in insertion of polytopic proteins into the inner membraneMGI:1929742  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6636: YDR013W, ENSP00000262460YDR013WPSF1: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machineryMGI:1916520  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3804: YDR021W, ENSP00000269349YDR021WFAL1: Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicasesMGI:1923731  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3551: YDR044W, ENSP00000264193YDR044WHEM13: Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)MGI:104841  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4578: YDR045C, ENSP00000293860YDR045CRPC11: RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcriptionMGI:1914255  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5246: YDR054C, ENSP00000263228YDR054CCDC34: Ubiquitin-conjugating enzyme or E2; together with Skp1p, Rbx1p, Cdc53p, and an F-box protein, forms a ubiquitin-protein ligase called the SCF complex which regulates cell cycle progression by targeting key substrates for degradationMGI:1914865  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5731: YDR060W, ENSP00000234170YDR060WMAK21: Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding proteinMGI:109386  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3041: YDR062W, ENSP00000216484YDR062WLCB2: Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganineMGI:108074  
No systematic deletion data for mouse, yeast is essentialORTHOMCL13066: YDR081C, ENSP00000355162YDR081CPDC2: Transcription factor required for the synthesis of the glycolytic enzyme pyruvate decarboxylase, required for high level expression of both the THI and the PDC genesMGI:2685264  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2921: YDR088C, ENSP00000297151YDR088CSLU7: RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domainMGI:2385598  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3687: YDR091C, ENSP00000296577YDR091CRLI1: Essential iron-sulfur protein required for ribosome biogenesis and translation initiation; facilitates binding of a multifactor complex (MFC) of translation initiation factors to the small ribosomal subunit; predicted ABC family ATPaseMGI:1195458  
No systematic deletion data for mouse, yeast is essentialORTHOMCL13063: YDR164C, ENSP00000221283YDR164CSEC1: Sm-like protein involved in docking and fusion of exocytic vesicles through binding to assembled SNARE complexes at the membrane; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE functionMGI:107370  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8088: YDR168W, ENSP00000222005YDR168WCDC37: Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycleMGI:109531  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4248: YDR177W, ENSP00000261427YDR177WUBC1: Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress responseMGI:1858216  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5069: YDR190C, ENSP00000318297YDR190CRVB1: Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein familyMGI:1928760  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4465: YDR196C, ENSP00000341504YDR196C: predicted to catalyze the final step in synthesis of Coenzyme AMGI:1915337  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4142: YDR212W, ENSP00000239585YDR212WTCP1: Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in maintenance of actin cytoskeleton; homolog to Drosophila melanogaster and mouse tailless complex polypeptideMGI:98535  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2286: YDR228C, ENSP00000298281YDR228CPCF11: mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p)MGI:1919579  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5414: YDR236C, ENSP00000257452YDR236CFMN1: Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membraneMGI:1914688  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3599: YDR238C, ENSP00000249923YDR238CSEC26: Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)MGI:1917599  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5515: YDR246W, ENSP00000351896YDR246WTRS23: One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4MGI:1926211  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3077: YDR267C, ENSP00000272402YDR267CCIA1: Essential protein involved in assembly of cytosolic and nuclear iron-sulfur proteinsMGI:1346998  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2926: YDR280W, ENSP00000243498YDR280WRRP45: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complexMGI:1355319  
No systematic deletion data for mouse, yeast is essentialORTHOMCL7867: YDR302W, ENSP00000281382YDR302WGPI11: ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homologMGI:99462  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3542: YDR311W, ENSP00000265963YDR311WTFB1: Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activatorsMGI:1277216  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3447: YDR325W, ENSP00000251496YDR325WYCG1: Non-SMC subunit of the condensin complex (Smc2p-Smc4p-Ycs4p-Brn1p-Ycg1p); required for establishment and maintenance of chromosome condensation, chromosome segregation and for chromatin binding of the condensin complexMGI:1930197  
No systematic deletion data for mouse, yeast is essentialORTHOMCL314: YDR328C, ENSP00000231487YDR328CSKP1: Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPaseMGI:103575  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4427: YDR365C, ENSP00000202816YDR365CESF1: Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levelsMGI:1913830  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4733: YDR376W, ENSP00000293195YDR376WARH1: Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viabilityMGI:104724  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4560: YDR390C, ENSP00000246548YDR390CUBA2: Nuclear protein that acts as a heterodimer with Aos1p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viabilityMGI:1858313  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3627: YDR397C, ENSP00000236164YDR397CNCB2: Beta subunit of the NC2 dimeric histone-fold complex; represses RNA polymerase II transcription through binding to TBP and inhibition of TFIIA and TFIIB; homologous to the Dr1 subunit of the mammalian NC2 (negative cofactor2)MGI:1100515  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5869: YDR398W, ENSP00000296126YDR398WUTP5: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:1919765  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4257: YDR404C, ENSP00000301788YDR404CRPB7: RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4pMGI:1914960  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2585: YDR427W, ENSP00000333811YDR427WRPN9: Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defectsMGI:1345192  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5360: YDR434W, ENSP00000309430YDR434WGPI17: Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homologMGI:2687325  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6236: YDR449C, ENSP00000261708YDR449CUTP6: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:2445193  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3681: YDR454C, ENSP00000317659YDR454CGUK1: Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteinsMGI:95871  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4662: YDR472W, ENSP00000316990YDR472WTRS31: One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane trafficMGI:1913932  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3232: YDR473C, ENSP00000236015YDR473CPRP3: Splicing factor, component of the U4/U6-U5 snRNP complexMGI:1918017  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6009: YDR489W, ENSP00000276533YDR489WSLD5: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machineryMGI:1923847  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5391: YEL002C, ENSP00000235894YEL002CWBP1: Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulumMGI:1194508  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6728: YEL055C, ENSP00000254718YEL055CPOL5: Protein with sequence similarity to the human MybBP1A and weak sequence similar to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNAMGI:106181  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2691: YER012W, ENSP00000246311YER012WPRE1: 20S proteasome beta-type subunit; localizes to the nucleus throughout the cell cycleMGI:1347045  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2877: YER013W, ENSP00000262415YER013WPRP22: DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexesMGI:1306823  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3910: YER021W, ENSP00000264639YER021WRPN3: Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle controlMGI:98858  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6999: YER048W-A, ENSP00000332502YER048W-AISD11: Protein required for mitochondrial iron-sulfur cluster biosynthesisMGI:2683538  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5052: YER082C, ENSP00000266008YER082CUTP7: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:1931871  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6696: YER093C, ENSP00000349959YER093CTSC11: Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domainMGI:1926007  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5624: YER126C, ENSP00000296802YER126CNSA2: Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesisMGI:1913883  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6056: YER146W, ENSP00000223084YER146WLSM5: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNAMGI:1913623  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3430: YER157W, ENSP00000350442YER157WCOG3: Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartmentsMGI:2450151  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4553: YFL002C, ENSP00000238146YFL002CSPB4: Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradientsMGI:1915098  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3555: YFL017C, ENSP00000216410YFL017CGNA1: Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA MGI:1858963  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4399: YFL022C, ENSP00000320309YFL022CFRS2: Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similarMGI:1913840  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5110: YFL045C, ENSP00000268261YFL045CSEC53: Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumenMGI:1859214  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2816: YFR003C, ENSP00000230260YFR003CYPI1: Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogenMGI:1923747  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5359: YFR004W, ENSP00000263639YFR004WRPN11: Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substratesMGI:1913284  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3298: YFR005C, ENSP00000312981YFR005CSAD1: Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particleMGI:107622  
No systematic deletion data for mouse, yeast is essentialORTHOMCL11758: YFR027W, ENSP00000269214YFR027WECO1: Acetyltransferase required for the establishment of sister chromatid cohesion during DNA replication, but not for its maintenance during G2 and M phases; also required for postreplicative double-strand break repair; interacts with Chl1pMGI:1925055  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3170: YFR050C, ENSP00000290541YFR050CPRE4: 20S proteasome beta-type subunitMGI:1098257  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1908: YGL011C, ENSP00000261479YGL011CSCL1: Alpha subunit of the 20S core complex of the 26S proteasome involved in the degradation of ubiquitinated substrates; essential for growth; detected in the mitochondriaMGI:1347006  
No systematic deletion data for mouse, yeast is essentialORTHOMCL7377: YGL018C, ENSP00000216027YGL018CJAC1: Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrixMGI:2141135  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6683: YGL040C, ENSP00000277315YGL040CHEM2: Delta-aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of delta-aminolevulinic acid to porphobilinogen, the second step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleusMGI:96853  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2806: YGL048C, ENSP00000310572YGL048CRPT6: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycleMGI:105047  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6734: YGL091C, ENSP00000283027YGL091CNBP35: Essential nuclear protein, evolutionarily conserved putative ATPase; exhibits genetic interaction with CDC2 encoding the catalytic subunit of DNA polymerase deltaMGI:1347073  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2093: YGL137W, ENSP00000329419YGL137WSEC27: Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COPMGI:1354962  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3462: YGL169W, ENSP00000350144YGL169WSUA5: Protein required for respiratory growth; null mutation suppresses the Cyc1p translation defect caused by the presence of an aberrant ATG codon upstream of the correct startMGI:2387201  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4226: YGL171W, ENSP00000268854YGL171WROK1: ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesisMGI:1925644  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3109: YGL201C, ENSP00000264156YGL201CMCM6: Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complexMGI:1298227  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3930: YGL207W, ENSP00000216297YGL207WSPT16: Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), facilitates RNA Polymerase II transcription elongation through nucleosomes by destabilizing and then reassembling nucleosome structureMGI:1890948  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3816: YGR024C, ENSP00000231198YGR024CTHG1: tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotesMGI:1913878  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4661: YGR047C, ENSP00000263956YGR047CTFC4: One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102MGI:2138383  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4508: YGR074W, ENSP00000300413YGR074WSMD1: Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1MGI:98344  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4435: YGR091W, ENSP00000324122YGR091WPRP31: Splicing factor, component of the U4/U6-U5 snRNP complexMGI:1916238  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2556: YGR095C, ENSP00000221233YGR095CRRP46: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complexMGI:107889  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5364: YGR145W, ENSP00000263836YGR145WENP2: Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1pMGI:2684913  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2308: YGR175C, ENSP00000265896YGR175CERG1: Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafineMGI:109296  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3132: YGR185C, ENSP00000257116YGR185CTYS1: Cytoplasmic tyrosyl-tRNA synthetase, class I aminoacyl-tRNA synthetase that aminoacylates tRNA(Tyr), required for cytoplasmic protein synthesis, interacts with positions 34 and 35 of the anticodon of tRNATyrMGI:2147627  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6212: YGR186W, ENSP00000245811YGR186WTFG1: TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74MGI:1923848  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3106: YGR218W, ENSP00000195419YGR218WCRM1: Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleusMGI:2144013  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2859: YGR246C, ENSP00000329029YGR246CBRF1: TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIBMGI:1919558  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3144: YGR253C, ENSP00000271308YGR253CPUP2: Alpha subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zetaMGI:1347009  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5933: YGR264C, ENSP00000262027YGR264CMES1: Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAsMGI:1345633  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6527: YGR277C, ENSP00000163059YGR277C: Putative protein of unknown function; sequence similarity to Pantetheine-phosphate adenylyltransferase (PPAT); YGR277C is an essential geneMGI:1918993  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6535: YGR280C, ENSP00000318966YGR280CPXR1: Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domainMGI:1919650  
No systematic deletion data for mouse, yeast is essentialORTHOMCL9419: YHR007C, ENSP00000003100YHR007CERG11: Lanosterol 14-alpha-demethylase, catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 familyMGI:106040  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8033: YHR019C, ENSP00000256854YHR019CDED81: Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNAMGI:1917473  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4622: YHR058C, ENSP00000256379YHR058CMED6: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationMGI:1917042  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5134: YHR062C, ENSP00000277882YHR062CRPP1: Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' endsMGI:1859683  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5749: YHR065C, ENSP00000350698YHR065CRRP3: Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activityMGI:1915005  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4812: YHR069C, ENSP00000253010YHR069CRRP4: Protein involved in rRNA processing; component of the exosome 3->5 exonuclease complex with Rrp41p, Rrp42p, Rrp43p and Dis3pMGI:2385133  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5427: YHR070W, ENSP00000261249YHR070WTRM5: tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and EukaryaMGI:1923607  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4413: YHR074W, ENSP00000326424YHR074WQNS1: Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotideMGI:1926164  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3630: YHR085W, ENSP00000344645YHR085WIPI1: Protein of unknown function, essential for viability, may be involved in rRNA processingMGI:1344413  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5106: YHR088W, ENSP00000263716YHR088WRPF1: Nucleolar protein involved in the assembly of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNAMGI:1917535  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3707: YHR166C, ENSP00000209827YHR166CCDC23: Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionMGI:1098815  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4317: YHR188C, ENSP00000279036YHR188CGPI16: Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homologMGI:1926178  
No systematic deletion data for mouse, yeast is essentialORTHOMCL11215: YIL003W, ENSP00000262302YIL003WCFD1: Highly conserved, putative P-loop ATPase localized in the cytoplasm; has a potential role in assembly of iron-sulfur clusters in proteinsMGI:1347072  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4531: YIL004C, ENSP00000222547YIL004CBET1: Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevinsMGI:1343104  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2302: YIL022W, ENSP00000270538YIL022WTIM44: Peripheral mitochondrial membrane protein involved in mitochondrial protein import, tethers essential chaperone Ssc1p to the translocon channel at the matrix side of the inner membraneMGI:1343262  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6255: YIL068C, ENSP00000323377YIL068CSEC6: Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assemblyMGI:2443972  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3384: YIL075C, ENSP00000309474YIL075CRPN2: Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1pMGI:1917497  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1678: YIL078W, ENSP00000265112YIL078WTHS1: Threonyl-tRNA synthetase, essential cytoplasmic proteinMGI:106314  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4491: YIL142W, ENSP00000299300YIL142WCCT2: Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoMGI:107186  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3770: YIL143C, ENSP00000285398YIL143CSSL2: Component of the holoenzyme form of RNA polymerase transcription factor TFIIH, has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; involved in DNA repair; homolog of human ERCC3MGI:95414  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4397: YIR008C, ENSP00000350491YIR008CPRI1: Subunit of DNA primase, which is required for DNA synthesis and double-strand break repairMGI:97757  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6614: YIR012W, ENSP00000248450YIR012WSQT1: Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assayMGI:107809  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4999: YJL002C, ENSP00000296255YJL002COST1: Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteinsMGI:98084  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5335: YJL008C, ENSP00000286788YJL008CCCT8: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoMGI:107183  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4089: YJL010C, ENSP00000267425YJL010CNOP9: Essential nucleolar protein required for 18S rRNA synthesisMGI:1915092  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8547: YJL011C, ENSP00000353589YJL011CRPC17: RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complexMGI:1100818  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4546: YJL014W, ENSP00000295688YJL014WCCT3: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoMGI:104708  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4681: YJL035C, ENSP00000237283YJL035CTAD2: Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAsMGI:1914007  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3977: YJL039C, ENSP00000285968YJL039CNUP192: Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205MGI:2141625  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4472: YJL050W, ENSP00000230640YJL050WMTR4: Dead-box family ATP dependent helicase required for mRNA export from the nucleus; co-factor of the exosome complex, required for 3' end formation of 5.8S rRNAMGI:1919448  
No systematic deletion data for mouse, yeast is essentialORTHOMCL7928: YJL069C, ENSP00000225298YJL069CUTP18: Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction dataMGI:1923402  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5393: YJL072C, ENSP00000253462YJL072CPSF2: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machineryMGI:1921019  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3326: YJL109C, ENSP00000264173YJL109CUTP10: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:2442524  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3779: YJL111W, ENSP00000258091YJL111WCCT7: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoMGI:107184  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4937: YJR002W, ENSP00000244230YJR002WMPP10: Component of the SSU processome, which is required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10pMGI:1915223  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4358: YJR006W, ENSP00000223361YJR006WHYS2: DNA polymerase III (delta) subunit, essential for cell viability; involved in DNA replication and DNA repairMGI:1097163  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3913: YJR013W, ENSP00000271552YJR013WGPI14: Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-MMGI:1914806  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3118: YJR064W, ENSP00000280326YJR064WCCT5: Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivoMGI:107185  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3822: YJR068W, ENSP00000296273YJR068WRFC2: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonMGI:2146571  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4355: YJR072C, ENSP00000264718YJR072CNPA3: Essential, conserved, cytoplasmic ATPase; phosphorylated by the Pcl1p-Pho85p kinase complexMGI:1921504  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2171: YJR123W, ENSP00000196551YJR123WRPS5: Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteinsMGI:1097682  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4767: YKL013C, ENSP00000287613YKL013CARC19: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patchesMGI:1915339  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4408: YKL014C, ENSP00000270201YKL014CURB1: Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunitMGI:2146468  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2914: YKL018W, ENSP00000328139YKL018WSWD2: Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription terminationMGI:1924555  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1629: YKL024C, ENSP00000294340YKL024CURA6: Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)MGI:1913838  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3061: YKL028W, ENSP00000283875YKL028WTFA1: TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter openingMGI:1921447  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5909: YKL033W, ENSP00000345782YKL033W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YKL033W is an essential geneMGI:1922675  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5003: YKL045W, ENSP00000274891YKL045WPRI2: Subunit of DNA primase, which is required for DNA synthesis and double-strand break repairMGI:97758  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4592: YKL058W, ENSP00000267869YKL058WTOA2: TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIAMGI:1933289  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6375: YKL082C, ENSP00000277417YKL082CRRP14: Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 familyMGI:98447  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4008: YKL099C, ENSP00000333151YKL099CUTP11: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:1914455  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3860: YKL145W, ENSP00000292644YKL145WRPT1: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and the E3 ubiquitin-protein ligase Ubr1pMGI:109555  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6001: YKL172W, ENSP00000236051YKL172WEBP2: Essential protein required for the maturation of 25S rRNA and 60S ribosomal subunit assembly, localizes to the nucleolus; constituent of 66S pre-ribosomal particlesMGI:1916322  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4203: YKL182W, ENSP00000290429YKL182WFAS1: Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activitiesMGI:2388651  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3009: YKL189W, ENSP00000258418YKL189WHYM1: Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating responseMGI:107438  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2417: YKL195W, ENSP00000295767YKL195WMIA40: Essential protein of the mitochondrial intermembrane space, involved in import and assembly of intermembrane space proteinsMGI:1919420  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4118: YKL196C, ENSP00000223369YKL196CYKT6: Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminusMGI:1927550  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4099: YKR038C, ENSP00000206542YKR038CKAE1: Putative glycoprotease that interacts with Bud32p, which is a member of the novel protein kinase piD261 familyMGI:1913496  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5172: YKR062W, ENSP00000348168YKR062WTFA2: TFIIE small subunit, involved in RNA polymerase II transcription initiationMGI:1915403  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3851: YKR068C, ENSP00000063037YKR068CBET3: Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complexMGI:1351486  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4839: YKR081C, ENSP00000349123YKR081CRPF2: Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particlesMGI:1914489  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6631: YKR086W, ENSP00000268482YKR086WPRP16: RNA helicase in the DEAH-box family involved in the second catalytic step of splicing, exhibits ATP-dependent RNA unwinding activityMGI:1927617  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5417: YLL008W, ENSP00000339633YLL008WDRS1: Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particlesMGI:2385884  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5551: YLL011W, ENSP00000297579YLL011WSOF1: Essential subunit of the U3 (box C+D) snRNP complex required for 2' O-methylation of pre-RNA; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4pMGI:2684929  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3533: YLL018C, ENSP00000264161YLL018CDPS1: Cytoplasmic aspartyl-tRNA synthetase, homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulationMGI:2442544  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2354: YLL036C, ENSP00000227524YLL036CPRP19: Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligasesMGI:106247  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6507: YLR002C, ENSP00000312669YLR002CNOC3: Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiationMGI:1932610  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4754: YLR022C, ENSP00000246868YLR022CSDO1: Essential protein involved in RNA metabolism, one of two yeast homologs (with Yhr087wp) of the human protein SBDS responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome, also conserved in ArchaeaMGI:1913961  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4610: YLR051C, ENSP00000183866YLR051CFCF2: Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulonMGI:1923173  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5201: YLR115W, ENSP00000298875YLR115WCFT2: Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein.MGI:1861601  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6186: YLR127C, ENSP00000314004YLR127CAPC2: Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; similar to cullin Cdc53pMGI:2139135  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3435: YLR147C, ENSP00000215829YLR147CSMD3: Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3MGI:1914582  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3808: YLR175W, ENSP00000253127YLR175WCBF5: Component of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), probable rRNA pseudouridine synthase, binds to snoRNP Nop10p and also interacts with ribosomal biogenesis protein Nop53pMGI:3040698  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6860: YLR186W, ENSP00000261406YLR186WEMG1: Protein required for the maturation of the 18S rRNA and for 40S ribosome production; associated with spindle/microtubules; nuclear localization depends on physical interaction with Nop14p; may bind snoRNAsMGI:1315195  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3651: YLR196W, ENSP00000258531YLR196WPWP1: Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamilyMGI:1914735  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3535: YLR197W, ENSP00000343111YLR197WSIK1: Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defectsMGI:1914384  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4643: YLR215C, ENSP00000281141YLR215CCDC123: Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 proteinMGI:2138811  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6061: YLR222C, ENSP00000331815YLR222CUTP13: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:2384863  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2855: YLR243W, ENSP00000228827YLR243W: Putative protein of unknown function; YLR243W is an essential geneMGI:1289326  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4793: YLR274W, ENSP00000216122YLR274WCDC46: Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phaseMGI:103197  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2399: YLR275W, ENSP00000342374YLR275WSMD2: Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2MGI:98345  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4493: YLR276C, ENSP00000258772YLR276CDBP9: ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunitMGI:1277172  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3366: YLR277C, ENSP00000238112YLR277CYSH1: Putative endonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex required for 3' processing of mRNAsMGI:1859328  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3843: YLR291C, ENSP00000266126YLR291CGCD7: Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expressionMGI:2145118  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3514: YLR305C, ENSP00000255882YLR305CSTT4: Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organizationMGI:2448506  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5722: YLR314C, ENSP00000344868YLR314CCDC3: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EMMGI:1335094  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5375: YLR316C, ENSP00000332448YLR316CTAD3: Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAsMGI:1928947  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2743: YLR323C, ENSP00000245419YLR323CCWC24: Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24pMGI:1917192  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5993: YLR359W, ENSP00000216194YLR359WADE13: Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathwayMGI:103202  
No systematic deletion data for mouse, yeast is essentialORTHOMCL12397: YLR397C, ENSP00000274008YLR397CAFG2: ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; may be involved in degradation of aberrant mRNAsMGI:1927170  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4774: YLR409C, ENSP00000319771YLR409CUTP21: Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction dataMGI:1917819  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5790: YLR424W, ENSP00000263115YLR424WSPP382: Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutationMGI:1930075  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5556: YLR438C-A, ENSP00000302160YLR438C-ALSM3: Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNAMGI:1914928  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5603: YML105C, ENSP00000282999YML105CSEC65: Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19MGI:1913634  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3875: YMR001C, ENSP00000300093YMR001CCDC5: Polo-like kinase with similarity to Xenopus Plx1 and S. pombe Plo1p; found at bud neck, nucleus and SPBs; has multiple functions in mitosis and cytokinesis through phosphorylation of substrates; may be a Cdc28p substrateMGI:97621  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4244: YMR049C, ENSP00000304151YMR049CERB1: Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1MGI:1334460  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5936: YMR061W, ENSP00000315791YMR061WRNA14: Cleavage and polyadenylation factor I (CF I) component involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in the CF I complexMGI:1351825  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6812: YMR093W, ENSP00000296792YMR093WUTP15: Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNAMGI:2145443  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2796: YMR128W, ENSP00000311135YMR128WECM16: Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesisMGI:3028576  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5184: YMR131C, ENSP00000253237YMR131CRRB1: Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3pMGI:2141989  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2887: YMR146C, ENSP00000197492YMR146CTIF34: Subunit of the core complex of translation initiation factor 3(eIF3), which is essential for translationMGI:1860763  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3142: YMR197C, ENSP00000281221YMR197CVTI1: Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathwaysMGI:1855699  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4889: YMR213W, ENSP00000265414YMR213WCEF1: Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5pMGI:1918952  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2510: YMR281W, ENSP00000225609YMR281WGPI12: ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-LpMGI:2681271  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3136: YMR290C, ENSP00000263239YMR290CHAS1: ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particlesMGI:1914192  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2236: YMR296C, ENSP00000262554YMR296CLCB1: Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganineMGI:1099431  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4300: YMR309C, ENSP00000332604YMR309CNIP1: Subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selectionMGI:1926966  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3728: YNL026W, ENSP00000345445YNL026WSAM50: Essential component of the Sorting and Assembly Machinery (SAM or Tob complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85MGI:1915903  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4562: YNL061W, ENSP00000313272YNL061WNOP2: Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particlesMGI:107891  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6123: YNL075W, ENSP00000259239YNL075WIMP4: Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAsMGI:106572  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3926: YNL102W, ENSP00000314415YNL102WPOL1: Catalytic subunit of the DNA polymerase alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesisMGI:99660  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3314: YNL113W, ENSP00000302478YNL113WRPC19: RNA polymerase subunit, common to RNA polymerases I and IIIMGI:108403  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1832: YNL118C, ENSP00000329359YNL118CDCP2: Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase familyMGI:1917890  
No systematic deletion data for mouse, yeast is essentialORTHOMCL7757: YNL124W, ENSP00000274054YNL124WNAF1: Protein required for the assembly of box H/ACA snoRNPs and for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; has similarity to Gar1p and other RNA-binding proteinsMGI:2682306  
No systematic deletion data for mouse, yeast is essentialORTHOMCL9325: YNL151C, ENSP00000231283YNL151CRPC31: RNA polymerase III subunit C31; contains HMG-like C-terminal domainMGI:1914736  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4941: YNL172W, ENSP00000339109YNL172WAPC1: Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transitionMGI:103097  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3713: YNL178W, ENSP00000278572YNL178WRPS3: Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteinsMGI:1350917  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6077: YNL182C, ENSP00000251289YNL182CIPI3: Protein required for cell viability; computational analysis of large-scale protein-protein interaction data suggests a possible role in assembly of the ribosomal large subunitMGI:2158400  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6744: YNL222W, ENSP00000291386YNL222WSSU72: Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivoMGI:1916241  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3346: YNL232W, ENSP00000306711YNL232WCSL4: Subunit of the exosome, which is an essential complex present in both nucleus and cytoplasm that mediates RNA processing and degradationMGI:1913833  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5761: YNL245C, ENSP00000225428YNL245CCWC25: Component of a complex containing Cef1p, involved in pre-mRNA splicing; has similarity to S. pombe Cwf25pMGI:1914730  
No systematic deletion data for mouse, yeast is essentialORTHOMCL10326: YNL260C, ENSP00000279147YNL260C: Protein required for cell viabilityMGI:1919534  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6088: YNL261W, ENSP00000297431YNL261WORC5: Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencingMGI:1347044  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4502: YNL262W, ENSP00000322570YNL262WPOL2: Catalytic subunit of DNA polymerase epsilon, one of the major chromosomal DNA replication polymerases characterized by processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repairMGI:1196391  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5002: YNL290W, ENSP00000229043YNL290WRFC3: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonMGI:1919401  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4310: YNL313C, ENSP00000313953YNL313C: Protein required for cell viabilityMGI:1921446  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4205: YNR003C, ENSP00000318757YNR003CRPC34: RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complexMGI:1924086  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4902: YNR035C, ENSP00000327137YNR035CARC35: Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulinMGI:1923959  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6065: YNR038W, ENSP00000333746YNR038WDBP6: Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein familyMGI:1916913  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4373: YNR043W, ENSP00000301012YNR043WMVD1: Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimerMGI:2179327  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3063: YNR053C, ENSP00000257129YNR053CNOG2: Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturationMGI:2385207  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2168: YNR054C, ENSP00000274849YNR054CESF2: Essential nucleolar protein involved in pre-18S rRNA processing; component of the small subunit (SSU) processome; has sequence similarity to mABT1, a mouse transcription activatorMGI:1353636  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4794: YOL010W, ENSP00000239262YOL010WRCL1: RNA terminal phosphate cyclase-like protein involved in rRNA processing at sites A0, A1, and A2; does not possess detectable RNA cyclase activityMGI:1913275  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5422: YOL022C, ENSP00000246535YOL022C: Protein required for cell viabilityMGI:1915329  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1081: YOL135C, ENSP00000286317YOL135CMED7: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulationMGI:1913463  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5866: YOL146W, ENSP00000318196YOL146WPSF3: Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machineryMGI:1926083  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6770: YOR004W, ENSP00000308332YOR004WUTP23: Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for functionMGI:1925831  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3281: YOR048C, ENSP00000262489YOR048CRAT1: Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as mRNA transcription terminationMGI:894687  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5238: YOR056C, ENSP00000268802YOR056CNOB1: Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNAMGI:1914869  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2682: YOR057W, ENSP00000298172YOR057WSGT1: Probable cochaperone, regulates activity of Cyr1p (adenylyl cyclase); involved in assembly of the kinetochore complex, associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complexMGI:1915205  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4326: YOR074C, ENSP00000315644YOR074CCDC21: Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/SMGI:98878  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4390: YOR077W, ENSP00000281372YOR077WRTS2: Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replicationMGI:96676  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2540: YOR095C, ENSP00000283646YOR095CRKI1: Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesisMGI:103254  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4714: YOR116C, ENSP00000277783YOR116CRPO31: RNA polymerase III subunit C160, part of core enzyme; similar to bacterial beta-prime subunitMGI:2681836  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2255: YOR119C, ENSP00000264874YOR119CRIO1: Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNAMGI:1918590  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8847: YOR149C, ENSP00000238138YOR149CSMP3: Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structureMGI:2443822  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4764: YOR151C, ENSP00000312735YOR151CRPB2: RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunitMGI:2388280  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2825: YOR157C, ENSP00000259457YOR157CPUP1: Endopeptidase with trypsin-like activity that cleaves after basic residues; beta-type subunit of 20S proteasome synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit ZMGI:107637  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5625: YOR168W, ENSP00000307567YOR168WGLN4: Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactionsMGI:1915851  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3152: YOR181W, ENSP00000223023YOR181WLAS17: Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP)MGI:1920428  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2127: YOR194C, ENSP00000298173YOR194CTOA1: TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIAMGI:1933277  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6287: YOR207C, ENSP00000228347YOR207CRET1: Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAsMGI:1917678  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4817: YOR210W, ENSP00000324124YOR210WRPB10: RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and IIIMGI:1913741  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1536: YOR217W, ENSP00000261424YOR217WRFC1: Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilonMGI:97891  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4402: YOR224C, ENSP00000296223YOR224CRPB8: RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and IIIMGI:2384309  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4043: YOR232W, ENSP00000264954YOR232WMGE1: Protein of the mitochondrial matrix involved in protein import into mitochondria; acts as a cochaperone and a nucleotide release factor for Ssc1p; homolog of E. coli GrpEMGI:1334417  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3327: YOR250C, ENSP00000304704YOR250CCLP1: Subunit of cleavage factor I (CFI), involved in both the endonucleolyitc cleavage and polyadenylation steps of mRNA 3'-end maturationMGI:2138968  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3027: YOR254C, ENSP00000027474YOR254CSEC63: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ERMGI:2155302  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3004: YOR259C, ENSP00000216407YOR259CRPT4: One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for spindle pole body duplication; localized mainly to the nucleus throughout the cell cycleMGI:1914339  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4993: YOR262W, ENSP00000341101YOR262W: Protein required for cell viabilityMGI:2140368  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8190: YOR281C, ENSP00000264254YOR281CPLP2: Essential protein with similarity to phosducins, which are GTPase inhibitors; lethality of null mutation is functionally complemented by expression of mouse phosducin-like protein MgcPhLPMGI:1916083  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4105: YOR287C, ENSP00000244496YOR287C: Protein required for cell viabilityMGI:2385053  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3730: YOR294W, ENSP00000322396YOR294WRRS1: Essential protein that binds ribosomal protein L11 and is required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; mouse homolog shows altered expression in Huntington's disease model miceMGI:1929721  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3655: YOR310C, ENSP00000264279YOR310CNOP58: Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNAMGI:1933184  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4850: YOR319W, ENSP00000271628YOR319WHSH49: U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM)MGI:109580  
No systematic deletion data for mouse, yeast is essentialORTHOMCL8311: YOR340C, ENSP00000222567YOR340CRPA43: RNA polymerase I subunit A43MGI:106292  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4015: YOR362C, ENSP00000216455YOR362CPRE10: 20S proteasome alpha-type subunitMGI:104883  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1484: YPL028W, ENSP00000265838YPL028WERG10: Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesisMGI:87870  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6609: YPL043W, ENSP00000223073YPL043WNOP4: Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs)MGI:2655711  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5537: YPL076W, ENSP00000258324YPL076WGPI2: Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C proteinMGI:1914542  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6249: YPL082C, ENSP00000265990YPL082CMOT1: Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificityMGI:2147538  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6749: YPL094C, ENSP00000337688YPL094CSEC62: Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ERMGI:1916526  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4975: YPL117C, ENSP00000263151YPL117CIDI1: Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viabilityMGI:2442264  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3318: YPL122C, ENSP00000259895YPL122CTFB2: Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIHMGI:1338799  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4831: YPL126W, ENSP00000314193YPL126WNAN1: U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNAMGI:1920924  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3085: YPL151C, ENSP00000303191YPL151CPRP46: Splicing factor that is found in the Cef1p subcomplex of the spliceosomeMGI:1858197  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4632: YPL160W, ENSP00000274562YPL160WCDC60: Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNAMGI:1913808  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3973: YPL169C, ENSP00000294172YPL169CMEX67: Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAPMGI:1858330  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5294: YPL210C, ENSP00000342181YPL210CSRP72: Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membraneMGI:1333795  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6286: YPL211W, ENSP00000254940YPL211WNIP7: Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43pMGI:1913414  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5297: YPL217C, ENSP00000298600YPL217CBMS1: Essential conserved nucleolar GTP-binding protein required for synthesis of 40S ribosomal subunits and for processing of the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, has similarity to Tsr1pMGI:2446132  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3464: YPL235W, ENSP00000221413YPL235WRVB2: Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; member of the RUVB-like protein familyMGI:1342299  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5210: YPL266W, ENSP00000199320YPL266WDIM1: Essential 18S rRNA dimethylase, responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18 S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processingMGI:1913504  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4691: YPR016C, ENSP00000246231YPR016CTIF6: Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunitsMGI:1196288  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4825: YPR025C, ENSP00000256897YPR025CCCL1: Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promotersMGI:1913921  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5313: YPR048W, ENSP00000343344YPR048WTAH18: Protein with a potential role in DNA replication; displays synthetic lethal genetic interaction with the pol3-13 allele of POL3, which encodes DNA polymerase deltaMGI:1926047  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5264: YPR056W, ENSP00000228955YPR056WTFB4: Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1pMGI:1277143  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5821: YPR082C, ENSP00000269601YPR082CDIB1: 17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of the human U5-specific 15-kDa proteinMGI:1351613  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4086: YPR086W, ENSP00000260511YPR086WSUA7: Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase IIMGI:2385191  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3198: YPR088C, ENSP00000216774YPR088CSRP54: Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domainMGI:1346087  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4704: YPR094W, ENSP00000216252YPR094WRDS3: Zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistanceMGI:2156864  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4164: YPR108W, ENSP00000295901YPR108WRPN7: Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunitsMGI:1913663  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2707: YPR110C, ENSP00000304153YPR110CRPC40: RNA polymerase subunit, common to RNA polymerase I and IIIMGI:103288  
No systematic deletion data for mouse, yeast is essentialORTHOMCL5116: YPR112C, ENSP00000261741YPR112CMRD1: Essential conserved protein that associates with 35S precursor rRNA and is required for its initial processing at the A(0)-A(2) cleavage sites, shows partial nucleolar localization, contains five consensus RNA-binding domainsMGI:1921361  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4289: YPR113W, ENSP00000219789YPR113WPIS1: Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteinsMGI:105491  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3774: YPR133C, ENSP00000295321YPR133CSPN1: Protein that interacts with Spt6p and copurifies with Spt5p and RNA polymerase II, probable transcriptional elongation factor; metazoan homologs contain an acidic N terminus; mutations in the gene confer an Spt- phenotypeMGI:1920723  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2847: YPR137W, ENSP00000232888YPR137WRRP9: Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k proteinMGI:2384313  
No systematic deletion data for mouse, yeast is essentialORTHOMCL6847: YPR143W, ENSP00000184772YPR143WRRP15: Nucleolar protein, constituent of pre-60S ribosomal particles; required for processing of the 27S pre-rRNA at the A2 site to yield 5.8S and 25S rRNAMGI:1914473  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3974: YPR144C, ENSP00000328854YPR144CNOC4: Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunitsMGI:2140843  
No systematic deletion data for mouse, yeast is essentialORTHOMCL1388: YPR165W, ENSP00000265538YPR165WRHO1: GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)MGI:1096342  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3781: YPR168W, ENSP00000255764YPR168WNUT2: Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcriptionMGI:106331  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4907: YPR175W, ENSP00000216367YPR175WDPB2: Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrateMGI:1197514  
No systematic deletion data for mouse, yeast is essentialORTHOMCL3890: YPR178W, ENSP00000344622YPR178WPRP4: Splicing factor, component of the U4/U6-U5 snRNP complexMGI:1917302  
No systematic deletion data for mouse, yeast is essentialORTHOMCL2166: YPR180W, ENSP00000270225YPR180WAOS1: Nuclear protein that acts as a heterodimer with Uba2p to activate Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viabilityMGI:1929264  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4449: YPR183W, ENSP00000001585YPR183WDPM1: Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylationMGI:1330239  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4053: YPR187W, ENSP00000215960YPR187WRPO26: RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunitMGI:1349393  
No systematic deletion data for mouse, yeast is essentialORTHOMCL4908: YPR190C, ENSP00000334564YPR190CRPC82: RNA polymerase III subunit C82MGI:1921664  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2435: YAL014C, ENSP00000305255YAL014CSYN8: Endosomal SNARE related to mammalian syntaxin 8MGI:1890156  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL9191: YAL020C, ENSP00000265965YAL020CATS1: Protein with a potential role in regulatory interactions between microtubules and the cell cycle, as suggested by genetic and physical interactions with Nap1p and genetic interactions with TUB1MGI:1351630  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2400: YAL035W, ENSP00000289371YAL035WFUN12: GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2MGI:2441772  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5291: YAL036C, ENSP00000329715YAL036CRBG1: Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46pMGI:1343297  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8949: YAL046C, ENSP00000331369YAL046C: Hypothetical proteinMGI:1925903  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4989: YAL049C, ENSP00000296658YAL049C: Hypothetical proteinMGI:1916824  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6401: YAR003W, ENSP00000264515YAR003WSWD1: Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7MGI:1918367  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5753: YAR035W, ENSP00000287862YAR035WYAT1: Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrixMGI:109176  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL15196: YBL007C, ENSP00000309186YBL007CSLA1: Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; contains 3 SH3 domains; interacts with proteins regulating actin dynamics and with proteins required for endocytosisMGI:2444637  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3927: YBL013W, ENSP00000220058YBL013WFMT1: Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrateMGI:1916856  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL550: YBL021C, ENSP00000240055YBL021CHAP3: Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA bindingMGI:97317  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3088: YBL036C, ENSP00000333551YBL036C: Single-domain racemase, possibly non-specific due to the lack of the second domain, which presumably determines specificityMGI:1891207  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2350: YBL057C, ENSP00000337494YBL057CPTH2: One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growthMGI:2444848  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2912: YBL080C, ENSP00000263985YBL080CPET112: Protein required for mitochondrial translation; mutation is functionally complemented by a Bacillus subtilis orthologMGI:2442496  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5167: YBL082C, ENSP00000311641YBL082CALG3: Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteinsMGI:1098592  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2247: YBL091C, ENSP00000325312YBL091CMAP2: Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1pMGI:1929701  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7632: YBL098W, ENSP00000262860YBL098WBNA4: Kynurenine 3-mono oxygenase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathwayMGI:2138151  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3234: YBL099W, ENSP00000282050YBL099WATP1: Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesisMGI:88115  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4038: YBR003W, ENSP00000277607YBR003WCOQ1: Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesisMGI:1889278  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4064: YBR026C, ENSP00000263702YBR026CETR1: 2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesisMGI:1349441  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5034: YBR058C, ENSP00000229268YBR058CUBP14: Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase TMGI:1347343  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL742: YBR074W, ENSP00000340427YBR074W: Putative metalloproteaseMGI:106250  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5080: YBR097W, ENSP00000349205YBR097WVPS15: Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1pMGI:1922919  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3457: YBR101C, ENSP00000255631YBR101CFES1: Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulumMGI:1913495  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7494: YBR111C, ENSP00000298425YBR111CYSA1: Nudix hydrolase family member with ADP-ribose pyrophosphatase activityMGI:1858232  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2722: YBR115C, ENSP00000205214YBR115CLYS2: Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5pMGI:2442517  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1309: YBR127C, ENSP00000276390YBR127CVMA2: Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasmMGI:109618  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3390: YBR133C, ENSP00000319169YBR133CHSL7: Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1pMGI:1351645  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4705: YBR146W, ENSP00000258455YBR146WMRPS9: Mitochondrial ribosomal protein of the small subunitMGI:1916777  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1727: YBR159W, ENSP00000278353YBR159WIFA38: Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides.MGI:1926967  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5021: YBR164C, ENSP00000261636YBR164CARL1: Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factorMGI:99436  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5880: YBR173C, ENSP00000255315YBR173CUMP1: Short-lived chaperone required for correct maturation of the 20S proteasome; degraded by proteasome upon completion of its assembly; involved in ubiquitin-mediated proteolysis; mutant defective in degradation of short-lived proteinsMGI:1913787  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6216: YBR175W, ENSP00000351446YBR175WSWD3: Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5MGI:2155884  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5584: YBR186W, ENSP00000166345YBR186WPCH2: Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNAMGI:1916966  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2254: YBR187W, ENSP00000257288YBR187W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YBR187W is an essential geneMGI:894407  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6206: YBR217W, ENSP00000274459YBR217WATG12: Ubiquitin-like modifier, conjugated via an isopeptide bond to a lysine residue of Atg5p by the E1 enzyme, Atg7p, and the E2 enzyme, Atg10p, a step that is essential for autophagyMGI:1914776  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2270: YBR221C, ENSP00000307241YBR221CPDB1: E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondriaMGI:1915513  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3130: YBR222C, ENSP00000320646YBR222CPCS60: Peroxisomal AMP-binding protein, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetaseMGI:2182591  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2528: YBR227C, ENSP00000300107YBR227CMCX1: Mitochondrial ATP-binding protein, possibly a mitochondrial chaperone with non-proteolytic function; similar to bacterial ClpX proteinsMGI:1346017  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6804: YBR231C, ENSP00000283882YBR231CSWC5: Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatinMGI:1344403  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL15453: YBR233W, ENSP00000305556YBR233WPBP2: RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere lengthMGI:1345635  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6045: YBR235W, ENSP00000275730YBR235W: Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential geneMGI:1933532  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6577: YBR246W, ENSP00000277540YBR246W: Hypothetical proteinMGI:1914478  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6390: YBR261C, ENSP00000343829YBR261C: Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBR261C is not an essential geneMGI:1913867  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5462: YBR269C, ENSP00000284225YBR269CFMP21: The authentic, non-tagged protein was localized to the mitochondriaMGI:1915252  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7464: YBR278W, ENSP00000233699YBR278WDPB3: Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycleMGI:1914229  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6262: YBR279W, ENSP00000221265YBR279WPAF1: RNA polymerase II-associated protein, defines a large complex that is biochemically and functionally distinct from the Srb-Mediator form of Pol II holoenzyme and is required for full expression of a subset of cell cycle-regulated genesMGI:1923988  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1494: YCL001W, ENSP00000302088YCL001WRER1: Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ERMGI:1915080  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4623: YCL010C, ENSP00000316114YCL010CSGF29: SaGa associated Factor 29kDa; Probable 29kKDa Subunit of SAGA histone acetyltransferase complexMGI:1922815  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5823: YCL016C, ENSP00000322180YCL016CDCC1: Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenanceMGI:1919357  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1645: YCL033C, ENSP00000277598YCL033C: Putative protein-methionine-R-oxide reductase; involved in response to oxidative stress; similar to mouse Sepx1p and fly SelRp; YCL033C is not an essential geneMGI:1923717  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1251: YCL039W, ENSP00000295024YCL039WGID7: Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functionsMGI:1923825  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2506: YCL045C, ENSP00000264214YCL045C: Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; interacts with Gal80p; YCL045C is not an essential geneMGI:2443696  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6044: YCL055W, ENSP00000274028YCL055WKAR4: Transcription factor required for induction of KAR3 and CIK1 during mating, also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromoneMGI:2442926  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12875: YCR002C, ENSP00000329161YCR002CCDC10: Component of the septin ring of the mother-bud neck that is required for cytokinesis; septins recruit proteins to the neck and can act as a barrier to diffusion at the membrane, and they comprise the 10nm filaments seen with EMMGI:1858222  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8154: YCR003W, ENSP00000223324YCR003WMRPL32: Mitochondrial ribosomal protein of the large subunitMGI:2137226  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL11461: YCR009C, ENSP00000276416YCR009CRVS161: Amphiphysin-like lipid raft protein; subunit of a complex (Rvs161p-Rvs167p) that regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stressMGI:1929883  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2483: YCR024C, ENSP00000281038YCR024CSLM5: Mitochondrial asparaginyl-tRNA synthetaseMGI:2142075  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4946: YCR027C, ENSP00000262187YCR027CRHB1: Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteinsMGI:97912  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3932: YCR036W, ENSP00000306817YCR036WRBK1: Putative ribokinaseMGI:1918586  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7949: YCR059C, ENSP00000284202YCR059CYIH1: Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT geneMGI:1098233  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5176: YCR063W, ENSP00000222969YCR063WBUD31: Protein involved in bud-site selection; analysis of integrated high-throughput datasets predicts an involvement in RNA splicing; diploid mutants display a random budding pattern instead of the wild-type bipolar patternMGI:2141291  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4080: YCR077C, ENSP00000300146YCR077CPAT1: Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1pMGI:2147679  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5834: YCR087C-A, ENSP00000345917YCR087C-A: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential geneMGI:107470  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6266: YCR090C, ENSP00000294360YCR090C: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential geneMGI:1921348  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5407: YDL033C, ENSP00000290846YDL033CSLM3: tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF)MGI:1919276  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4245: YDL047W, ENSP00000238362YDL047WSIT4: Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organizationMGI:1915107  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6479: YDL072C, ENSP00000343458YDL072CYET3: Endoplasmic reticulum transmembrane protein, homolog of human BAP31 proteinMGI:1350933  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7419: YDL091C, ENSP00000261942YDL091CUBX3: UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternMGI:1923827  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5451: YDL116W, ENSP00000229179YDL116WNUP84: Subunit of the nuclear pore complex (NPC), forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export and NPC biogenesisMGI:2143854  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12217: YDL119C, ENSP00000273158YDL119C: Putative mitochondrial transport protein; localizes to the mitochondrion; YDL119C is not an essential geneMGI:2384782  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6593: YDL122W, ENSP00000257548YDL122WUBP1: Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chainsMGI:2140991  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3693: YDL142C, ENSP00000202507YDL142CCRD1: Cardiolipin synthase; produces cardiolipin, which is an important constituent of mitochondrial membranes; required for normal mitochondrial membrane potential and functionMGI:1913836  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12548: YDL156W, ENSP00000263795YDL156W: Hypothetical proteinMGI:1926186  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1574: YDL185W, ENSP00000273398YDL185WTFP1: Vacuolar ATPase V1 domain subunit A containing the catalytic nucleotide binding sites; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonucleaseMGI:1201780  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8219: YDL200C, ENSP00000302111YDL200CMGT1: DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damageMGI:96977  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4914: YDL201W, ENSP00000314441YDL201WTRM8: Subunit of a tRNA methyltransferase complex composed of Trm8p and Trm82p that catalyzes 7-methylguanosine modification of tRNAMGI:1339986  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5534: YDL219W, ENSP00000262550YDL219WDTD1: D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotesMGI:1913294  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6688: YDR004W, ENSP00000343392YDR004WRAD57: Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55pMGI:1921585  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12499: YDR006C, ENSP00000299045YDR006CSOK1: Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13MGI:2444679  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6612: YDR057W, ENSP00000185150YDR057WYOS9: Lectin; soluble lumenal ER protein; member of the OS-9 protein family; similar to mannose-6-phosphate receptors (MPRs); serves as a receptor that recognizes misfolded N-glycosylated proteins and participates in their targeting to ERADMGI:1914003  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8815: YDR071C, ENSP00000250615YDR071CPAA1: Polyamine acetyltransferase; acetylates polyamines such as putrescine, spermidine and spermine; may be involved in transcription and/or DNA replication via regulation of levels of polyamines bound to chromosomal DNAMGI:1328365  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2810: YDR075W, ENSP00000279387YDR075WPPH3: Catalytic subunit of an evolutionarily conserved protein phosphatase complex containing Psy2p and the regulatory subunit Psy4p; required for cisplatin resistance; involved in activation of Gln3pMGI:1891763  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3053: YDR083W, ENSP00000254605YDR083WRRP8: Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutationMGI:1914251  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2018: YDR092W, ENSP00000316176YDR092WUBC13: Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleusMGI:1934835  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3043: YDR105C, ENSP00000342962YDR105CTMS1: Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistanceMGI:1926228  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL13073: YDR115W, ENSP00000252602YDR115W: Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteinsMGI:2137227  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4944: YDR121W, ENSP00000277334YDR121WDPB4: Shared subunit of DNA polymerase epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencingMGI:1933378  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5641: YDR140W, ENSP00000303584YDR140WMTQ2: S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; methylates release factor eRF1 (Sup45p) in vitro; is not an essential gene; similar to E.coli PrmCMGI:1915018  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6591: YDR198C, ENSP00000329189YDR198CRKM2: Ribosomal protein lysine methyltransferaseMGI:2136890  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4987: YDR204W, ENSP00000300452YDR204WCOQ4: Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complexMGI:1098826  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6007: YDR221W, ENSP00000252455YDR221WGTB1: Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ERMGI:107877  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL10017: YDR248C, ENSP00000277124YDR248C: Hypothetical proteinMGI:1922981  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2650: YDR268W, ENSP00000235521YDR268WMSW1: Mitochondrial tryptophanyl-tRNA synthetaseMGI:1917810  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1720: YDR284C, ENSP00000314854YDR284CDPP1: Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolismMGI:1919160  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8542: YDR286C, ENSP00000296662YDR286C: Hypothetical proteinMGI:1924672  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL10148: YDR323C, ENSP00000253699YDR323CPEP7: Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritanceMGI:1925537  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4591: YDR329C, ENSP00000036971YDR329CPEX3: Peroxisomal membrane protein (PMP) required to recruit Pex19p chaperone to peroxisomes; plays selective, essential, direct role in PMP import as a docking factor for Pex19pMGI:1929646  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1889: YDR330W, ENSP00000296328YDR330WUBX5: UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48pMGI:2146388  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4237: YDR336W, ENSP00000303802YDR336W: Hypothetical proteinMGI:1913317  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4309: YDR337W, ENSP00000264287YDR337WMRPS28: Mitochondrial ribosomal protein of the small subunitMGI:1913657  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4018: YDR363W-A, ENSP00000248566YDR363W-ASEM1: Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; ortholog of human DSS1MGI:109238  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4974: YDR364C, ENSP00000304370YDR364CCDC40: Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeatsMGI:1918963  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2159: YDR430C, ENSP00000224949YDR430CCYM1: Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphologyMGI:1916867  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7823: YDR432W, ENSP00000309558YDR432WNPL3: RNA-binding protein that carries poly(A)+ mRNA from the nucleus into the cytoplasm; phosphorylation by Sky1p in the cytoplasm may promote release of mRNAsMGI:1917689  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL9792: YDR452W, ENSP00000253065YDR452WPPN1: Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimerMGI:1916022  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8122: YDR511W, ENSP00000353548YDR511WACN9: Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotesMGI:1913288  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL10140: YDR517W, ENSP00000313869YDR517WGRH1: Protein involved in the spindle assembly checkpoint; homolog of human GRASP65, which is a Golgi localized protein that functions in postmitotic reassembly of Golgi stacksMGI:1921748  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4196: YEL003W, ENSP00000271485YEL003WGIM4: Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to itMGI:1276111  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4551: YEL020C, ENSP00000323811YEL020C: Hypothetical protein with low sequence identity to Pdc1pMGI:1929657  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4594: YEL051W, ENSP00000216442YEL051WVMA8: Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysisMGI:1921084  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2693: YEL052W, ENSP00000258002YEL052WAFG1: Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to mitochondriaMGI:2148801  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7885: YEL062W, ENSP00000232501YEL062WNPR2: Regulator of nitrogen permeases; transcription is induced in response to proline and urea; contains two PEST sequencesMGI:1914482  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL16396: YER005W, ENSP00000347031YER005WYND1: Apyrase with wide substrate specificity, involved in preventing the inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates which are inhibitors of glycotransferases; partially redundant with Gda1pMGI:2135885  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4415: YER014W, ENSP00000343943YER014WHEM14: Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IXMGI:104968  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL11220: YER044C, ENSP00000256319YER044CERG28: Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6pMGI:1915571  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7295: YER049W, ENSP00000337196YER049WTPA1: Hypothetical proteinMGI:2442978  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5229: YER069W, ENSP00000293404YER069WARG5,6: Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2pMGI:2387600  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6861: YER078C, ENSP00000349658YER078C: Metallopeptidase, localized to the mitochondrial matrixMGI:2445217  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4906: YER087W, ENSP00000294375YER087W: Hypothetical proteinMGI:2386296  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2867: YER140W, ENSP00000305198YER140W: Hypothetical proteinMGI:2683537  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4400: YER151C, ENSP00000219473YER151CUBP3: Ubiquitin-specific protease that interacts with Bre5p to co-regulate anterograde and retrograde transport between endoplasmic reticulum and Golgi compartments; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitinMGI:894652  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1641: YER156C, ENSP00000267103YER156C: Hypothetical proteinMGI:1929864  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6511: YER170W, ENSP00000276892YER170WADK2: Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain backgroundMGI:1860835  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1589: YER178W, ENSP00000254142YER178WPDA1: E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA, regulated by glucoseMGI:97532  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3509: YER183C, ENSP00000258874YER183CFAU1: 5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesisMGI:1340032  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6523: YFL027C, ENSP00000246077YFL027CGYP8: GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transportMGI:1914481  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5120: YFL030W, ENSP00000302620YFL030WAGX1: Alanine : glyoxylate aminotransferase, catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine : glyoxylate aminotransferasesMGI:1329033  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3188: YFL036W, ENSP00000215591YFL036WRPO41: Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognitionMGI:1915843  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7162: YFL044C, ENSP00000326813YFL044COTU1: Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) familyMGI:2442596  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4917: YFL046W, ENSP00000260054YFL046WFMP32: The authentic, non-tagged protein was localized to the mitochondriaMGI:1913615  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL9890: YFL047W, ENSP00000267939YFL047WRGD2: GTPase-activating protein (RhoGAP) for Cdc42p and Rho5pMGI:1321396  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5249: YFR006W, ENSP00000244137YFR006W: Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential geneMGI:97542  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6230: YFR009W, ENSP00000292808YFR009WGCN20: Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNAMGI:1351656  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL16441: YFR033C, ENSP00000327693YFR033CQCR6: Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1MGI:3045324  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5950: YFR041C, ENSP00000259293YFR041CERJ5: Endoplasmic reticulum protein that may function as a cochaperone, as suggested by the presence of a DnaJ-like domainMGI:103268  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL9879: YFR047C, ENSP00000219771YFR047CBNA6: Quinolinate phosphoribosyl transferase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathwayMGI:1914625  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2870: YGL003C, ENSP00000221926YGL003CCDH1: Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of mitotic cyclins resulting in exit from mitosis; targets the APC/C to specific substrates including CDC20, ASE1 and CIN8MGI:1926790  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2450: YGL027C, ENSP00000233616YGL027CCWH41: Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stressMGI:1929872  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6406: YGL029W, ENSP00000227520YGL029WCGR1: Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stressMGI:1277220  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL11283: YGL050W, ENSP00000294637YGL050WTYW3: Hypothetical proteinMGI:2445040  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL14041: YGL059W, ENSP00000005178YGL059W: Hypothetical proteinMGI:1351481  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3283: YGL070C, ENSP00000221859YGL070CRPB9: RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site; involved in telomere maintenanceMGI:1917170  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8616: YGL094C, ENSP00000257931YGL094CPAN2: Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexesMGI:1918984  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3735: YGL095C, ENSP00000259149YGL095CVPS45: Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartmentMGI:891965  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5636: YGL124C, ENSP00000296473YGL124CMON1: Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrateMGI:1920075  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4538: YGL127C, ENSP00000225728YGL127CSOH1: Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunitsMGI:1914529  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3846: YGL136C, ENSP00000327660YGL136CMRM2: Mitochondrial 21S rRNA methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJMGI:1915267  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4759: YGL154C, ENSP00000278618YGL154CLYS5: Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheineMGI:1914868  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12135: YGL156W, ENSP00000267978YGL156WAMS1: Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathwayMGI:1920994  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7182: YGL173C, ENSP00000264951YGL173CKEM1: Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenanceMGI:891964  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2560: YGL174W, ENSP00000260210YGL174WBUD13: Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar patternMGI:2443443  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2459: YGL203C, ENSP00000262288YGL203CKEX1: Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteinsMGI:1921867  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3540: YGL211W, ENSP00000270637YGL211WNCS6: Protein with a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hostsMGI:2385277  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5236: YGL231C, ENSP00000267750YGL231C: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulumMGI:1915282  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6756: YGL232W, ENSP00000173569YGL232WTAN1: Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNAMGI:2444479  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6214: YGL244W, ENSP00000260373YGL244WRTF1: Subunit of the RNA polymerase II-associated Paf1 complex; directly or indirectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in telomere maintenanceMGI:1309480  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3997: YGL246C, ENSP00000337759YGL246CRAI1: Nuclear protein that binds to and stabilizes the exoribonuclease Rat1p, required for pre-rRNA processingMGI:1890444  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6784: YGR001C, ENSP00000279993YGR001C: Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiaeMGI:1915293  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2747: YGR006W, ENSP00000298452YGR006WPRP18: Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, recruited to the spliceosome by Slu7pMGI:1914479  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6380: YGR019W, ENSP00000268251YGR019WUGA1: Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilizationMGI:2443582  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4315: YGR020C, ENSP00000249289YGR020CVMA7: Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membraneMGI:1913394  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6110: YGR021W, ENSP00000258975YGR021W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrionMGI:1917457  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL700: YGR028W, ENSP00000260709YGR028WMSP1: Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPaseMGI:1915229  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3470: YGR031W, ENSP00000222800YGR031W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrionMGI:1916008  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4736: YGR033C, ENSP00000169551YGR033CTIM21: Constituent of the mitochondrial inner membrane presequence translocase (TIM23 complex); may regulate protein import by binding to both the translocase of the outer membrane (TOM) and presequence-associated motor (PAM) complexesMGI:1920595  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7746: YGR036C, ENSP00000300477YGR036CCAX4: Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylationMGI:1914093  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4752: YGR054W, ENSP00000273435YGR054W: Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2AMGI:1098684  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5420: YGR057C, ENSP00000285071YGR057CLST7: Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surfaceMGI:2442184  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4047: YGR061C, ENSP00000313490YGR061CADE6: Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathwayMGI:2684864  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6582: YGR062C, ENSP00000295890YGR062CCOX18: Mitochondrial inner membrane protein, required for export of the Cox2p C terminus from the mitochondrial matrix to the intermembrane space during its assembly into cytochrome c oxidase; similar to Oxa2p of N. crassaMGI:2448532  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3709: YGR078C, ENSP00000286428YGR078CPAC10: Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein foldingMGI:1333804  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL11624: YGR080W, ENSP00000303908YGR080WTWF1: Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assemblyMGI:1346078  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4640: YGR093W, ENSP00000326411YGR093W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleusMGI:1919752  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3268: YGR096W, ENSP00000319574YGR096WTPC1: Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier familyMGI:1914533  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4771: YGR101W, ENSP00000325421YGR101WPCP1: Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidasesMGI:1277152  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5555: YGR135W, ENSP00000044462YGR135WPRE9: 20S proteasome beta-type subunit; the only nonessential 20S subunitMGI:1347060  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8646: YGR169C, ENSP00000007264YGR169CPUS6: Pseudouridine synthase responsible for modification of cytoplasmic and mitochondrial tRNAs at position 31; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viabilityMGI:1919186  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5298: YGR171C, ENSP00000282276YGR171CMSM1: Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1pMGI:2444136  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2982: YGR173W, ENSP00000225729YGR173WRBG2: Protein with similarity to mammalian developmentally regulated GTP-binding proteinMGI:1342307  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5023: YGR187C, ENSP00000321320YGR187CHGH1: Protein of unknown function with similarity to human HMG1 and HMG2; localizes to the cytoplasmMGI:1930628  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3833: YGR194C, ENSP00000207870YGR194CXKS1: Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strainsMGI:2142985  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4188: YGR207C, ENSP00000311930YGR207C: Protein of unknown function; homolog of mammalian electron transfer flavoprotein complex subunit ETF-beta; interacts with frataxin (Yfh1p)MGI:106098  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3083: YGR208W, ENSP00000275605YGR208WSER2: Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen sourceMGI:97788  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4644: YGR220C, ENSP00000264995YGR220CMRPL9: Mitochondrial ribosomal protein of the large subunitMGI:2137204  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8043: YGR223C, ENSP00000348848YGR223CHSV2: Phosphatidylinositol 3,5-bisphosphate-binding protein, predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localizationMGI:1859606  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7010: YGR232W, ENSP00000217958YGR232WNAS6: Regulatory, non-ATPase subunit of the 26S proteasome; homolog of the human oncoprotein gankyrin, which interacts with the retinoblastoma tumor suppressor (Rb) and cyclin-dependent kinase 4/6MGI:1858898  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12239: YGR234W, ENSP00000298352YGR234WYHB1: Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responsesMGI:2151886  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5605: YGR284C, ENSP00000277359YGR284CERV29: Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargoMGI:98445  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3924: YHL010C, ENSP00000330813YHL010C: Putative protein of unknown function, contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequencesMGI:1919649  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4980: YHL021C, ENSP00000263182YHL021CFMP12: The authentic, non-tagged protein was localized to the mitochondriaMGI:1891372  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5983: YHL031C, ENSP00000225724YHL031CGOS1: v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28MGI:1858260  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6034: YHR004C, ENSP00000321732YHR004CNEM1: Protein of the nuclear envelope required for the spherical shape of the nucleus; required for normal sporulationMGI:1914431  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3192: YHR026W, ENSP00000236067YHR026WPPA1: Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domainMGI:1890510  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5230: YHR051W, ENSP00000317780YHR051WCOX6: Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levelsMGI:88474  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2734: YHR078W, ENSP00000341588YHR078W: Hypothetical proteinMGI:1914799  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL11521: YHR114W, ENSP00000260506YHR114WBZZ1: SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosinsMGI:1925642  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8692: YHR116W, ENSP00000347469YHR116WCOX23: Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17pMGI:1913683  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4988: YHR156C, ENSP00000304903YHR156CLIN1: Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replicationMGI:1917483  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL10064: YHR181W, ENSP00000272438YHR181WSVP26: Integral membrane protein of the early Golgi apparatus, may function to promote retention of proteins in the early Golgi compartment; mutation affects protein N-glycosylation and cell wall integrityMGI:1096575  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3527: YHR189W, ENSP00000334277YHR189WPTH1: One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for cell growth and for mitochondrial respirationMGI:1913779  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2765: YHR207C, ENSP00000331557YHR207CSET5: Zinc-finger protein of unknown function, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virusMGI:1916976  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12484: YIL001W, ENSP00000232744YIL001W: Hypothetical proteinMGI:1933148  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8576: YIL008W, ENSP00000300461YIL008WURM1: Ubiquitin-like protein with only weak sequence similarity to ubiquitin; depends on the E1-like activating enzyme Uba4p; molecular function of the Urm1p pathway is unknown, but it is required for normal growth, particularly at high temperatureMGI:1915455  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL13120: YIL042C, ENSP00000219794YIL042CPKP1: Mitochondrial kinase, phosphorylates pyruvate dehydrogenase alpha subunit Pda1pMGI:1276121  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4615: YIL064W, ENSP00000351845YIL064W: Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand familyMGI:1919346  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5915: YIL073C, ENSP00000340995YIL073CSPO22: Meiosis-specific protein with similarity to phospholipase A2, involved in completion of nuclear divisions during meiosis; induced early in meiosisMGI:1933237  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6369: YIL097W, ENSP00000302830YIL097WFYV10: Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains CTLH domainMGI:1891748  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4693: YIL103W, ENSP00000263083YIL103WDPH1: Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11pMGI:2151233  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2424: YIR001C, ENSP00000216727YIR001CSGN1: Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiationMGI:1859158  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7640: YIR002C, ENSP00000267433YIR002CMPH1: Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, mutations confer a mutator phenotypeMGI:2442306  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4879: YIR026C, ENSP00000194039YIR026CYVH1: Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; transcription induced by low temperature and nitrogen starvation; member of the dual-specificity family of protein phosphatasesMGI:1890614  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL11763: YIR029W, ENSP00000252505YIR029WDAL2: Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradationMGI:2136971  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12819: YJL036W, ENSP00000251775YJL036WSNX4: Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX domain; forms complex with Snx41p and Atg20pMGI:1916400  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2111: YJL044C, ENSP00000253692YJL044CGYP6: GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transportMGI:1919488  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2809: YJL063C, ENSP00000288937YJL063CMRPL8: Mitochondrial ribosomal protein of the large subunitMGI:1351608  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4779: YJL101C, ENSP00000229416YJL101CGSH1: Gamma glutamylcysteine synthetase, catalyzes the first step in the gamma-glutamyl cycle for glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercuryMGI:104990  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3220: YJL124C, ENSP00000310596YJL124CLSM1: Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAsMGI:1914457  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5659: YJL126W, ENSP00000289807YJL126WNIT2: Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily memberMGI:1350916  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5573: YJL140W, ENSP00000272645YJL140WRPB4: RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; dispensable under some environmental conditions; involved in export of mRNA to cytoplasm under stress conditions; involved in telomere maintenanceMGI:1916491  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4835: YJL179W, ENSP00000261813YJL179WPFD1: Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulinMGI:1914449  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7106: YJL180C, ENSP00000304017YJL180CATP12: Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthaseMGI:2180561  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4641: YJL187C, ENSP00000262300YJL187CSWE1: Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrateMGI:2137630  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL480: YJR001W, ENSP00000217420YJR001WAVT1: Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transportersMGI:1194488  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5536: YJR010C-A, ENSP00000233025YJR010C-ASPC1: Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complexMGI:1916269  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5045: YJR014W, ENSP00000280557YJR014WTMA22: Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; has homology to human protein DRP1, which interacts with human Tma20p homolog MCT-1MGI:1915434  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2316: YJR019C, ENSP00000217455YJR019CTES1: Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acidsMGI:2158201  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL16966: YJR036C, ENSP00000298068YJR036CHUL4: Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viabilityMGI:2442663  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6059: YJR055W, ENSP00000225410YJR055WHIT1: Protein of unknown function, required for growth at high temperatureMGI:3051596  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6651: YJR058C, ENSP00000263270YJR058CAPS2: Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complexMGI:2141861  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4683: YJR070C, ENSP00000250937YJR070CLIA1: Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyses hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioningMGI:1915964  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2351: YJR088C, ENSP00000220853YJR088C: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulumMGI:1913986  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5752: YJR102C, ENSP00000253794YJR102CVPS25: Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosomeMGI:106354  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3028: YJR121W, ENSP00000262030YJR121WATP2: Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesisMGI:107801  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4246: YJR122W, ENSP00000317297YJR122WCAF17: Mitochondrial protein that interacts with Ccr4p in the two-hybrid system; 3'-untranslated region contains a putative mRNA localization element common to genes encoding mitochondrial proteinsMGI:3041174  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5204: YJR131W, ENSP00000320290YJR131WMNS1: Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membraneMGI:2684954  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5140: YKL002W, ENSP00000310440YKL002WDID4: Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosisMGI:1916203  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5281: YKL003C, ENSP00000355154YKL003CMRP17: Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activatorMGI:2153111  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5317: YKL009W, ENSP00000062038YKL009WMRT4: Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolusMGI:1917152  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL863: YKL025C, ENSP00000282391YKL025CPAN3: Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexesMGI:1919837  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3399: YKL033W-A, ENSP00000252304YKL033W-A: Putative protein of unknown function; similar to uncharacterized proteins from other fungiMGI:1914615  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6149: YKL047W, ENSP00000297761YKL047W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasmMGI:2444256  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4091: YKL053C-A, ENSP00000304997YKL053C-AMDM35: Protein of unknown function; mutation affects mitochondrial distribution and morphologyMGI:1916326  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2029: YKL080W, ENSP00000285415YKL080WVMA5: Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membraneMGI:1913585  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2237: YKL085W, ENSP00000327070YKL085WMDH1: Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycleMGI:97050  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL10061: YKL086W, ENSP00000302030YKL086WSRX1: Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxins Tsa1p and Ahp1p that are formed upon exposure to oxidants; conserved in higher eukaryotesMGI:104971  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4455: YKL100C, ENSP00000262657YKL100C: Hypothetical proteinMGI:95886  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6458: YKL143W, ENSP00000304233YKL143WLTV1: Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for growth at low temperatureMGI:2447810  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4686: YKL188C, ENSP00000263889YKL188CPXA2: Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteinsMGI:1349216  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4259: YKL190W, ENSP00000234310YKL190WCNB1: Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1MGI:107172  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3741: YKL191W, ENSP00000255108YKL191WDPH2: Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11pMGI:1914978  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3950: YKL197C, ENSP00000248633YKL197CPEX1: AAA-family ATPase peroxin required for peroxisome biogenesis, contains two 230 amino acid ATP-binding AAA cassettes, upregulated in anaerobiosis; Pex1p and Pex6p interact via their N-terminal AAA-cassettesMGI:1918632  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4238: YKL207W, ENSP00000245046YKL207W: Hypothetical proteinMGI:1913337  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4145: YKL216W, ENSP00000219240YKL216WURA1: Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acidMGI:1928378  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL989: YKR026C, ENSP00000228958YKR026CGCN3: Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expressionMGI:2384802  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL10682: YKR074W, ENSP00000352720YKR074W: Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasmMGI:1920353  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3253: YKR088C, ENSP00000316792YKR088CTVP38: Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate patternMGI:2140359  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4912: YLL018C-A, ENSP00000342015YLL018C-ACOX19: Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidaseMGI:1915283  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL638: YLL019C, ENSP00000347759YLL019CKNS1: Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residuesMGI:1098669  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4075: YLL041C, ENSP00000235768YLL041CSDH2: Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinoneMGI:1914930  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6377: YLR017W, ENSP00000297736YLR017WMEU1: Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expressionMGI:1914152  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2016: YLR025W, ENSP00000217402YLR025WSNF7: One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranesMGI:1922858  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1837: YLR038C, ENSP00000246554YLR038CCOX12: Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of fully active cytochrome c oxidase but not required for activity after assemblyMGI:107460  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5082: YLR059C, ENSP00000265881YLR059CREX2: RNA exonuclease, required for U4 snRNA maturation; functions redundantly with Rnh70p in 5.8S rRNA maturation, and with Rnh70p and Rex3p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases MGI:1888981  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4740: YLR065C, ENSP00000340697YLR065C: Putative protein of unknown function; YLR065C is not an essential geneMGI:1913570  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4171: YLR069C, ENSP00000264263YLR069CMEF1: Mitochondrial elongation factor involved in translational elongationMGI:107339  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5366: YLR074C, ENSP00000270812YLR074CBUD20: Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar patternMGI:1915290  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5630: YLR077W, ENSP00000333799YLR077WFMP25: The authentic, non-tagged protein was localized to the mitochondriaMGI:2137600  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6755: YLR085C, ENSP00000188312YLR085CARP6: Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexesMGI:1914269  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6949: YLR114C, ENSP00000315568YLR114CAVL9: Mutation is syntheticly lethal with apl2 vps1 double mutantMGI:1926187  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5482: YLR143W, ENSP00000256538YLR143W: Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential geneMGI:1913882  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3525: YLR148W, ENSP00000220509YLR148WPEP3: Vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis, forms complex with Pep5p that mediates protein transport to the vacuoleMGI:2443626  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4514: YLR172C, ENSP00000251159YLR172CDPH5: Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasmMGI:1916990  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6739: YLR181C, ENSP00000011652YLR181CVTA1: Multivesicular body (MVB) protein involved in endosomal protein sorting; binds to Vps20p and Vps4p; may regulate Vps4p function; bindsVps60p and may act at a late step in MVB formation; mutants show class E vacuolar-protein sorting defectsMGI:1913451  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6298: YLR191W, ENSP00000295030YLR191WPEX13: Integral peroxisomal membrane receptor for the PTS1 peroxisomal matrix protein signal recognition factor Pex5p, required for the translocation of peroxisomal matrix proteins, also interacts with Pex7p and Pex14p, contains a C-terminal SH3 domainMGI:1919379  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5480: YLR192C, ENSP00000261868YLR192CHCR1: Dual function protein involved in translation initiation as a substoichiometric component of eukaryotic translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNAMGI:1925905  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5344: YLR200W, ENSP00000230251YLR200WYKE2: Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actinMGI:95908  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5969: YLR201C, ENSP00000262507YLR201CCOQ9: Mitochondrial inner membrane protein required for ubiquinone (coenzyme Q) biosynthesis, which in turn is required for respiratory growth; exhibits genetic interaction with ABC1, suggesting a possible common functionMGI:1915164  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL9924: YLR231C, ENSP00000264170YLR231CBNA5: Kynureninase, required for biosynthesis of nicotinic acid from tryptophan via kynurenine pathwayMGI:1918039  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5221: YLR244C, ENSP00000296411YLR244CMAP1: Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2pMGI:1922874  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4503: YLR268W, ENSP00000286336YLR268WSEC22: R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homologMGI:1338759  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6411: YLR271W, ENSP00000281932YLR271W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YLR271W is not an essential geneMGI:1858435  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7877: YLR281C, ENSP00000253233YLR281C: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential geneMGI:1919900  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4327: YLR289W, ENSP00000281543YLR289WGUF1: Mitochondrial GTPase of unknown function, similar to E. coli elongation factor-type GTP-binding protein LepA and to LK1236.1 from Caenorhabditis elegansMGI:2140726  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5788: YLR306W, ENSP00000253023YLR306WUBC12: Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymesMGI:108278  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6723: YLR351C, ENSP00000265259YLR351CNIT3: Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily memberMGI:1261838  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3100: YLR377C, ENSP00000253266YLR377CFBP1: Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolismMGI:95492  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2014: YLR380W, ENSP00000252430YLR380WCSR1: Phosphatidylinositol transfer protein with a potential role in lipid turnover; interacts specifically with thioredoxin peroxidase (Tsa2p) and may have a role in oxidative stress resistanceMGI:1924013  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3866: YLR382C, ENSP00000265537YLR382CNAM2: Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenanceMGI:2142973  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4236: YLR386W, ENSP00000261776YLR386WVAC14: Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; activator of Fab1pMGI:2157980  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4121: YLR398C, ENSP00000347346YLR398CSKI2: Putative RNA helicase, involved in exosome mediated 3' to 5' mRNA degradation and translation inhibition of non-poly(A) mRNAs; forms complex with Ski3p and Ski8p; required for repressing propagation of dsRNA virusesMGI:1099835  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8372: YLR405W, ENSP00000265720YLR405WDUS4: Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3pMGI:1919166  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7081: YLR417W, ENSP00000258599YLR417WVPS36: Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosomeMGI:1917410  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6039: YLR418C, ENSP00000256767YLR418CCDC73: Constituent of Paf1 complex with RNA polymerase II, Paf1p, Hpr1p, Ctr9, Leo1, Rtf1 and Ccr4p, distinct from Srb-containing Pol II complexes; required for expression of certain genes, modification of some histones, and telomere maintenanceMGI:2384876  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2758: YLR421C, ENSP00000253003YLR421CRPN13: Subunit of the 19S regulatory particle of the 26S proteasome lidMGI:1929289  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4838: YLR435W, ENSP00000289479YLR435WTSR2: Protein with a potential role in pre-rRNA processingMGI:1916749  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3998: YLR439W, ENSP00000259038YLR439WMRPL4: Mitochondrial ribosomal protein of the large subunitMGI:1921850  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6658: YML005W, ENSP00000329858YML005WTRM12: S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNAMGI:1915510  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7931: YML030W, ENSP00000274787YML030W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YML030W is not an essential geneMGI:1914294  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4202: YML042W, ENSP00000315013YML042WCAT2: Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranesMGI:109501  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL1399: YML054C, ENSP00000217301YML054CCYB2: Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditionsMGI:96011  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3978: YML067C, ENSP00000201023YML067CERV41: Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transportMGI:1914706  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8881: YML096W, ENSP00000260952YML096W: Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10MGI:1917646  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3521: YML102W, ENSP00000315700YML102WCAC2: Component of the chromatin assembly complex (with Rlf2p and Msi1p) that assembles newly synthesized histones onto recently replicated DNA, required for building functional kinetochores, conserved from yeast to humansMGI:1314881  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5535: YML110C, ENSP00000288532YML110CCOQ5: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; located in mitochondriaMGI:1098643  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL13075: YMR004W, ENSP00000222990YMR004WMVP1: Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuoleMGI:2443816  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2794: YMR009W, ENSP00000333666YMR009WADI1: Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditionsMGI:2144929  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7800: YMR022W, ENSP00000338348YMR022WQRI8: Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assemblyMGI:1343188  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4967: YMR026C, ENSP00000225873YMR026CPEX12: RING-finger peroxisomal membrane peroxin that plays an essential role in peroxisome biogenesis and peroxisomal matrix protein import, forms translocation subcomplex with Pex2p and Pex10pMGI:2144177  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3670: YMR027W, ENSP00000275299YMR027W: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential geneMGI:1920669  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6087: YMR035W, ENSP00000329553YMR035WIMP2: Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1pMGI:2135611  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4580: YMR048W, ENSP00000261881YMR048WCSM3: Protein required for accurate chromosome segregation during meiosisMGI:1921571  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3819: YMR074C, ENSP00000221784YMR074C: Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR074C is not an essential geneMGI:1913538  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5601: YMR077C, ENSP00000317468YMR077CVPS20: Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranesMGI:3583942  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4677: YMR125W, ENSP00000259464YMR125WSTO1: Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80MGI:2140419  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2264: YMR130W, ENSP00000238379YMR130W: Hypothetical proteinMGI:1919998  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6802: YMR132C, ENSP00000348933YMR132CJLP2: Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)MGI:1914429  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5198: YMR152W, ENSP00000252638YMR152WYIM1: Protein of unknown function; proposed to be involved in responding to DNA damaging agentsMGI:2178759  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2667: YMR188C, ENSP00000285298YMR188CMRPS17: Mitochondrial ribosomal protein of the small subunitMGI:1913508  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4649: YMR193W, ENSP00000199706YMR193WMRPL24: Mitochondrial ribosomal protein of the large subunitMGI:1915861  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3487: YMR217W, ENSP00000295920YMR217WGUA1: GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvationMGI:2448526  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4434: YMR231W, ENSP00000300793YMR231WPEP5: Peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; forms complex with Pep3p that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, also interacts with Pep7pMGI:1918982  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4690: YMR272C, ENSP00000219368YMR272CSCS7: Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growthMGI:2443327  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2572: YMR292W, ENSP00000229314YMR292WGOT1: Evolutionarily conserved non-essential protein present in early Golgi cisternae that may be involved in ER-Golgi transport at a step after vesicle tethering to Golgi membranes, exhibits membrane topology similar to that of Sft2pMGI:1914214  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2778: YMR300C, ENSP00000264220YMR300CADE4: Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathwayMGI:2387203  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4985: YNL001W, ENSP00000274311YNL001WDOM34: Probable RNA-binding protein, functions in protein translation to promote G1 progression and differentiation, required for meiotic cell divisionMGI:2145154  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5225: YNL003C, ENSP00000336801YNL003CPET8: S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growthMGI:1914832  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3042: YNL005C, ENSP00000225969YNL005CMRP7: Mitochondrial ribosomal protein of the large subunitMGI:2137224  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2745: YNL021W, ENSP00000334061YNL021WHDA1: Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylationMGI:1333752  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5162: YNL035C, ENSP00000267522YNL035C: Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential geneMGI:1919588  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6932: YNL037C, ENSP00000217901YNL037CIDH1: Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycleMGI:1099463  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL729: YNL044W, ENSP00000222008YNL044WYIP3: Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1pMGI:1201692  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL8373: YNL063W, ENSP00000232854YNL063WMTQ1: S-adenosylmethionine-dependent Methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential geneMGI:1916786  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL2849: YNL071W, ENSP00000280346YNL071WLAT1: Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoAMGI:2385311  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5421: YNL072W, ENSP00000221486YNL072WRNH201: Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis; cooperates with Rad27p nucleaseMGI:1916974  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7566: YNL091W, ENSP00000287263YNL091WNST1: Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1MGI:1923017  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4350: YNL107W, ENSP00000247843YNL107WYAF9: Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domainMGI:1927224  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5501: YNL148C, ENSP00000221855YNL148CALF1: Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenanceMGI:1913661  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL12863: YNL155W, ENSP00000220669YNL155W: Hypothetical proteinMGI:1913611  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL5542: YNL168C, ENSP00000314622YNL168CFMP41: The authentic, non-tagged protein was localized to mitochondriaMGI:1915886  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL4627: YNL202W, ENSP00000219481YNL202WSPS19: Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleateMGI:1347059  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL6299: YNL219C, ENSP00000316397YNL219CALG9: Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylationMGI:1924753  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL3153: YNL224C, ENSP00000316109YNL224C: Hypothetical proteinMGI:1913799  
No systematic deletion data for mouse, yeast is nonessentialORTHOMCL7289: YNL252C, ENSP00000312311YNL252CMRPL17: Mitochondrial ribosomal protein of the large subunitMGI:1914558  
No systematic deletion data for mouse, y