YCL018W LEU2 322128 LEU2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper demonstrates complementation or suppression of an E. coli leuB mutation by an unidentified yeast DNA segment. leuB YCL018W LEU2 322128 LEU2 SACCHAROMYCES_CEREVISIAE SALMONELLA_TYPHIMURIUM no expt This paper demonstrates complementation or suppression of a Salmonella leuB mutation by an unidentified yeast DNA segment. leuB YOR202W HIS3 322128 HIS3 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper demonstrates complementation or suppression of an E. coli hisB mutation by an unidentified yeast DNA segment. hisB YBR082C UBC4 1310935 CG7425-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes Drosophila CG7425-PA (UbcD1) complements a yeast ubc4 ubc5 double mutant. YDR059C UBC5 1310935 CG7425-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes Drosophila CG7425-PA (UbcD1) complements a yeast ubc4 ubc5 double mutant. YNL088W TOP2 1331984 ENSMUSP00000068896|ENSMUSP00000074395 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YKL209C STE6 1348873 ENSMUSP00000041204 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YAR015W ADE1 1368674 C-ADE1 CANDIDA_MALTOSA SACCHAROMYCES_CEREVISIAE yes YIL126W STH1 1408766 ENSP00000218157|ENSP00000344854 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YOR290C SNF2 1408766 ENSP00000218157|ENSP00000344854 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YOR101W RAS1 1429624 P21H-RAS BOS_TAURUS SACCHAROMYCES_CEREVISIAE yes This paper shows that bovine P21H-RAS complements a yeast ras1 ras2 mutant that also has a temperature-sensitive cdc25 mutation. Yeast CDC25 was added back to the ras1 ras2 cdc25ts mutant to study the interaction between yeast Cdc25p and bovine P21H-RAS. YNL098C RAS2 1429624 P21H-RAS BOS_TAURUS SACCHAROMYCES_CEREVISIAE yes This paper shows that bovine P21H-RAS complements a yeast ras1 ras2 mutant that also has a temperature-sensitive cdc25 mutation. Yeast CDC25 was added back to the ras1 ras2 cdc25ts mutant to study the interaction between yeast Cdc25p and bovine P21H-RAS. YKL216W URA1 1446837 ENSP00000219240 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDL137W ARF2 1447192 ARF GIARDIA_LAMBLIA SACCHAROMYCES_CEREVISIAE yes G. lamblia ARF complements a yeast arf1 arf2 double mutant. YDL192W ARF1 1447192 ARF GIARDIA_LAMBLIA SACCHAROMYCES_CEREVISIAE yes G. lamblia ARF complements a yeast arf1 arf2 double mutant. YDL137W ARF2 1447192 ENSP00000298316 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF6 complements a yeast arf1 arf2 double mutant. YDL192W ARF1 1447192 ENSP00000298316 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF6 complements a yeast arf1 arf2 double mutant. YDL137W ARF2 1447192 ENSP00000000233 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF5 complements a yeast arf1 arf2 double mutant. YDL192W ARF1 1447192 ENSP00000000233 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF5 complements a yeast arf1 arf2 double mutant. YCL027W FUS1 1521771 FUS1 SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_KLUYVERI no expt "S. cerevisiae FUS1 was expressed in S. kluyveri, but no complementatrion experiment was performed." NONE YIL035C CKA1 1527008 CG17520-PA|CG17520-PB|CG17520-PC DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes The D. melanogaster casein kinase II alpha subunits (encoded by the gene CG17520) can rescue a yeast cka1 cka2 double mutant. YOR061W CKA2 1527008 CG17520-PA|CG17520-PB|CG17520-PC DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes The D. melanogaster casein kinase II alpha subunits (encoded by the gene CG17520) can rescue a yeast cka1 cka2 double mutant. YHR042W NCP1 1544575 cytochrome c P450 reductase RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt YJL005W CYR1 1545803 ESAG 4 TRYPANOSOMA_BRUCEI SACCHAROMYCES_CEREVISIAE yes YJL005W CYR1 1545803 GRESAG 4.1 TRYPANOSOMA_BRUCEI SACCHAROMYCES_CEREVISIAE yes YIR008C PRI1 1572541 ENSMUSP00000026461 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no YKL045W PRI2 1572541 ENSMUSP00000027312 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no YOR208W PTP2 1577774 PTP2 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no cdc25 YPL248C GAL4 1645781 GAL4 SACCHAROMYCES_CEREVISIAE MUS_MUSCULUS no expt This paper presents an analysis of the yeast GAL4 UAS in mouse cells. NONE YJR057W CDC8 1657913 TmpK VACCINIA_VIRUS SACCHAROMYCES_CEREVISIAE yes YIL061C SNP1 1714384 ENSP00000221448 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "This paper shows that human SNRP70 (ENSP00000221448) alone cannot complement the yeast snp1 mutation. However, the yeast snp1 mutation can be rescued by a chimera in which over half the yeast gene is replaced with the homologous region of the human SNRP70 gene, indicating some functional conservation between the two proteins." YBR160W CDC28 1714386 ENSP00000266970 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper describes complementation of a yeast cdc28 mutant by the 298aa peptide ENSP00000266970. The shorter peptide ENSP00000243067, which is also a product of ENSG00000123374, lacks 2 tyrosine kinase domains and is not a member of the same OrthoMCL family as Cdc28p." YBR160W CDC28 1714386 ENSP00000306043 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper describes complementation of a yeast cdc28 mutant by the 297aa peptide ENSP00000306043. The shorter peptide ENSP00000325970, which is also a product of ENSG00000170312, lacks 2 tyrosine kinase domains and is not a member of the same OrthoMCL family as Cdc28p." YER023W PRO3 1730675 ENSP00000328858 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YKL085W MDH1 1731644 mdh ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes This paper shows that E. coli mdh partially complementats a yeast mdh1 null mutant. YKL085W MDH1 1731644 Mdh2 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes This paper shows that rat Mdh2 (also known as Mor1) partially complements a yeast mdh1 null mutant. YGR152C RSR1 1732742 ENSP00000235108|ENSP00000348786 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YAL040C CLN3 1833066 ENSP00000319027 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR199W CLN1 1833066 ENSP00000319027 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPL256C CLN2 1833066 ENSP00000319027 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YAL040C CLN3 1833066 ENSP00000227507 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR199W CLN1 1833066 ENSP00000227507 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPL256C CLN2 1833066 ENSP00000227507 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YAL040C CLN3 1833066 ENSP00000262643|ENSP00000350625 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A 305 aa peptide of human cyclin E complements a yeast cln1 cln2 cln3 triple mutant. YMR199W CLN1 1833066 ENSP00000262643|ENSP00000350625 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A 305 aa peptide of human cyclin E complements a yeast cln1 cln2 cln3 triple mutant. YPL256C CLN2 1833066 ENSP00000262643|ENSP00000350625 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A 305 aa peptide of human cyclin E complements a yeast cln1 cln2 cln3 triple mutant. YAL040C CLN3 1833066 ENSP00000274026 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR199W CLN1 1833066 ENSP00000274026 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPL256C CLN2 1833066 ENSP00000274026 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YAL040C CLN3 1833066 ENSP00000256442 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR199W CLN1 1833066 ENSP00000256442 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPL256C CLN2 1833066 ENSP00000256442 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YAL040C CLN3 1833066 UNKNOWN:cyclin B2 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR199W CLN1 1833066 UNKNOWN:cyclin B2 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPL256C CLN2 1833066 UNKNOWN:cyclin B2 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YBR160W CDC28 1840925 AT3G48750.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes This paper shows that A. thaliana CDC2 partially complements an S. cerevisiae cdc28 mutant. YGL248W PDE1 1847489 ENSP00000270478|ENSP00000293683|ENSP00000270474|ENSP00000370078 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human hPDE1 (later called PDE4A; see OMIM entry 600126) complements a yeast pde1 pde2 double mutant. YOR360C PDE2 1847489 ENSP00000270478|ENSP00000293683|ENSP00000270474|ENSP00000370078 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human hPDE1 (later called PDE4A; see OMIM entry 600126) complements a yeast pde1 pde2 double mutant. YOR360C PDE2 1849280 ENSP00000270478|ENSP00000293683|ENSP00000270474|ENSP00000370078 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A human dunce-like phophodiesterase suppresses the constitutive yeast RAS2Val19 mutant and complements a yeast pde1 pde2 double mutant. YGL248W PDE1 1849280 ENSP00000270478|ENSP00000293683|ENSP00000270474|ENSP00000370078 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A human dunce-like phophodiesterase suppresses the constitutive yeast RAS2Val19 mutant and complements a yeast pde1 pde2 double mutant. YOR360C PDE2 1849280 ENSP00000255006|ENSP00000366590 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human RIN2 suppresses the constitutive yeast RAS2Val19 mutant but fails to suppress a pde1 pde2 double mutant. YGL248W PDE1 1849280 ENSP00000255006|ENSP00000366590 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human RIN2 suppresses the constitutive yeast RAS2Val19 mutant but fails to suppress a pde1 pde2 double mutant. YOR360C PDE2 1849280 ENSP00000265960|ENSP00000265961|ENSP00000362595|ENSP00000362596|ENSP00000362597|ENSP00000362599|ENSP00000362602|ENSP00000362604|ENSP00000362610 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human MAPKAP1 suppresses the constitutive yeast RAS2Val19 mutant but fails to suppress a pde1 pde2 double mutant. YGL248W PDE1 1849280 ENSP00000265960|ENSP00000265961|ENSP00000362595|ENSP00000362596|ENSP00000362597|ENSP00000362599|ENSP00000362602|ENSP00000362604|ENSP00000362610 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human MAPKAP1 suppresses the constitutive yeast RAS2Val19 mutant but fails to suppress a pde1 pde2 double mutant. YOR360C PDE2 1849280 ENSP00000310406 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human RIN1 suppresses the constitutive yeast RAS2Val19 mutant but fails to suppress a pde1 pde2 double mutant. YGL248W PDE1 1849280 ENSP00000310406 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human RIN1 suppresses the constitutive yeast RAS2Val19 mutant but fails to suppress a pde1 pde2 double mutant. YNL312W RFA2 1885001 ENSP00000263698 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YDL137W ARF2 1899243 ENSP00000272102 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF1 complements a yeast arf1 arf2 double mutant. YDL192W ARF1 1899243 ENSP00000272102 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF1 complements a yeast arf1 arf2 double mutant. YDL137W ARF2 1899243 ENSP00000306010 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF4 complements a yeast arf1 arf2 double mutant. YDL192W ARF1 1899243 ENSP00000306010 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ARF4 complements a yeast arf1 arf2 double mutant. YOL127W RPL25 1920406 RPL25 SACCHAROMYCES_CEREVISIAE XENOPUS_LAEVIS no expt YDR477W SNF1 1924320 RKIN1 SECALE_CEREALE SACCHAROMYCES_CEREVISIAE yes YPR183W DPM1 1978413 DPM1 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS no expt UNKNOWN YGL055W OLE1 1978720 stearoyl-CoA desaturase RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YNL238W KEX2 1988035 KEX2 SACCHAROMYCES_CEREVISIAE CRICETULUS_GRISEUS no expt This paper describes the expression of yeast Kex2p endopeptidase in baby hamster kidney (BHK) cells in order to induce endoproteolytic processing of the coexpressed human protein C precursor. YNL135C FPR1 1996117 FPR1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YNL135C FPR1 1996117 ENSP00000262925 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Based on references referred to in this paper, the authors appear to be referring to FKBP1A (ENSP00000262925)." YJR057W CDC8 2017365 ENSP00000304802|ENSP00000341279 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGL097W SRM1 2022190 SRM1 SACCHAROMYCES_CEREVISIAE CRICETULUS_GRISEUS yes YJL005W CYR1 2065652 eESAG4c TRYPANOSOMA_EQUIPERDUM SACCHAROMYCES_CEREVISIAE yes YKL184W SPE1 2103440 SPE1 SACCHAROMYCES_CEREVISIAE NICOTIANA_RUSTICA no expt YHR005C GPA1 2111439 Galphas RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes "Partially complements the growth and morphological phenotypes, but cells are still sterile. " YHR005C GPA1 2111439 Galphai RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YHR005C GPA1 2111439 Galphao RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YKR059W TIF1 2119809 ENSMUSP00000023599 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no YOL081W IRA2 2121369 ENSP00000351015|ENSP00000348498 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All 3 peptides map to the same human gene, ENSG00000196712." YBR140C IRA1 2121371 ENSP00000351015|ENSP00000348498 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All 3 peptides map to the same human gene, ENSG00000196712." YOL081W IRA2 2121371 ENSP00000351015|ENSP00000348498 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All 3 peptides map to the same human gene, ENSG00000196712." YKR059W TIF1 2169888 TIF1 SACCHAROMYCES_CEREVISIAE ORYCTOLAGUS_CUNICULUS no expt Yeast eIF-4A was analyzed in a rabbit reticulocyte expression system. NONE YGL040C HEM2 2178784 ENSP00000277315 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGR204W ADE3 2186031 Mthfd1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YOR061W CKA2 2196445 CG17520-PA|CG17520-PB|CG17520-PC DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes The D. melanogaster casein kinase II alpha subunits (encoded by the gene CG17520) can rescue a yeast cka1 cka2 double mutant. YIL035C CKA1 2196445 CG17520-PA|CG17520-PB|CG17520-PC DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes The D. melanogaster casein kinase II alpha subunits (encoded by the gene CG17520) can rescue a yeast cka1 cka2 double mutant. YBR135W CKS1 2227411 suc1+ SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YBR135W CKS1 2227411 ENSP00000243756 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YBR135W CKS1 2227411 ENSP00000311083 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Ensembl peptide ENSP00000311083 maps to the human CKS1B gene ENSG00000173207 which is located on chromosome 1 and corresponds to SwissProt accession id P61024. YNL238W KEX2 2284001 KEX2 SACCHAROMYCES_CEREVISIAE MUS_MUSCULUS no expt This paper describes the characterization of yeast KEX2 endoprotease activity in mouse NIH 3T3 fibroblasts. YPL248C GAL4 2405489 GAL4 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS no expt This paper describes an in vitro biochemical characterization of yeast GAL4 in HeLa cell extracts. NONE YOR074C CDC21 2646281 TS CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes The C. albicans gene TS encodes thymidylate synthase. YJL187C SWE1 2649252 SWE1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes This paper shows that S. cerevisiae SWE1 (alias MIH1) is the functional homolog of the cdc25+ mitotic inducer of S. pombe. YJL187C SWE1 2649252 wee1+ SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE no expt This paper shows that expression of S. pombe wee1+ in an S. cerevisiae swe1 (alias mih1) strain prevents the initiation of mitosis. YOL139C CDC33 2663851 ENSMUSP00000087625 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes The mouse eIF-4E protein described in this paper is only 198aa long. YJL005W CYR1 2682634 CYR1 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YOR386W PHR1 2689865 PHR1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YER023W PRO3 2824433 PRO3 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes proC YER023W PRO3 2824433 PRO3 SACCHAROMYCES_CEREVISIAE SALMONELLA_TYPHIMURIUM no proC YDR300C PRO1 2824433 PRO1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes proB YDR300C PRO1 2824433 PRO1 SACCHAROMYCES_CEREVISIAE SALMONELLA_TYPHIMURIUM yes proB YOR323C PRO2 2824433 PRO2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no proA YOR323C PRO2 2824433 PRO2 SACCHAROMYCES_CEREVISIAE SALMONELLA_TYPHIMURIUM yes proA YEL021W URA3 2835631 DdPYR5-6 DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes DdPYR5-6 encodes a bifunctional enzyme that complements both the ura3 and ura5 mutations in yeast. YML106W URA5 2835631 DdPYR5-6 DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes DdPYR5-6 encodes a bifunctional enzyme that complements both the ura3 and ura5 mutations in yeast. YGL008C PMA1 2891694 pma1+ SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YGL008C PMA1 2900469 PMA1 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS no expt "This paper shows expression of yeast PMA1 in human fibroblasts, but not a complementation experiment." NONE YLR420W URA4 2907604 PYR3 USTILAGO_MAYDIS SACCHAROMYCES_CEREVISIAE yes PYR3 also complements an E. coli pyrC mutation. YOR386W PHR1 2911265 PHR1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no expt This paper describes the expression of the S. cerevisiae photoreactivation repair PHR1 gene attached to the 5'-flanking sequence of the CYC-1 gene in S. pombe. The transformed photoreactivation repair (Phr) negative S. pombe cells acquired high Phr activity. YJR048W CYC1 2911265 CYC1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no expt This paper describes the expression of the S. cerevisiae photoreactivation repair PHR1 gene attached to the 5'-flanking sequence of the CYC-1 gene in S. pombe. The transformed photoreactivation repair (Phr) negative S. pombe cells acquired high Phr activity. YNL098C RAS2 2981628 ENSP00000309845 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ENSP00000309845 (HRAS) complements a yeast ras1 ras2 double mutant. YOR101W RAS1 2981628 ENSP00000309845 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ENSP00000309845 (HRAS) complements a yeast ras1 ras2 double mutant. YML032C RAD52 3045825 RAD52 SACCHAROMYCES_CEREVISIAE BACTERIOPHAGE_T4 yes gene 46 YML032C RAD52 3045825 RAD52 SACCHAROMYCES_CEREVISIAE BACTERIOPHAGE_T4 yes gene 47 YPL248C GAL4 3047590 GAL4 SACCHAROMYCES_CEREVISIAE CRICETULUS_GRISEUS no expt This paper describes an analysis of the transcriptional activating activity of yeast Gal4p domains in CHO cells. NONE YHR007C ERG11 3065144 P450L1A1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YHR005C GPA1 3113738 Galphas RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YPL248C GAL4 3128741 GAL4 SACCHAROMYCES_CEREVISIAE DROSOPHILA_MELANOGASTER no expt This paper shows that yeast Gal4p is active in Drosophila tissues. NONE YPL248C GAL4 3165494 GAL4 SACCHAROMYCES_CEREVISIAE NICOTIANA_TABACUM no expt This paper shows that yeast Gal4p is active in tobacco cells NONE YCL018W LEU2 3256308 LEU2 SACCHAROMYCES_CARLSBERGENSIS SACCHAROMYCES_CEREVISIAE yes YDR050C TPI1 3521890 tpiA ASPERGILLUS_NIDULANS SACCHAROMYCES_CEREVISIAE yes YOR202W HIS3 3543377 HIS3 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes hisB YNL098C RAS2 3939254 ENSP00000309845 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt YOR101W RAS1 3939254 ENSP00000309845 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt YJR057W CDC8 6091111 TK HUMAN_HERPESVIRUS_1 SACCHAROMYCES_CEREVISIAE yes YJR048W CYC1 6287225 CYTOCHROME C SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YKL211C TRP3 6294052 TRP3 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes YOL086C ADH1 6294096 Alcohol dehydrogenase SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YML106W URA5 6323917 UNKNOWN:not named DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes This Dictyostelium gene encodes a bifunctional enzyme that complements both the ura3 and ura5 mutations in yeast. YEL021W URA3 6323917 UNKNOWN:not named DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes This Dictyostelium gene encodes a bifunctional enzyme that complements both the ura3 and ura5 mutations in yeast. YBR010W HHT1 6350605 BGAL/HHT1 ESCHERICHIA_COLI/SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes the expression of a chimeric construct containing yeast histone H3 (HHT1 or HHT2) fused to beta-galactosidase. The yeast histone H3 fragment has the GenBank ID of K009000.1 which may correspond to either yeast HHT1 or the identical HHT2 protein. YNL031C HHT2 6350605 BGAL/HHT2 ESCHERICHIA_COLI/SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes the expression of a chimeric construct containing yeast histone H3 (HHT1 or HHT2) fused to beta-galactosidase. The yeast histone H3 fragment has the GenBank ID of K009000.1 which may correspond to either yeast HHT1 or the identical HHT2 protein. YCL043C PDI1 7499282 PDI RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YHR175W CTR2 7499355 AT5G59030.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper describes the cloning of A. thaliana COPT1 by complementation of yeast a ctr1 mutant; however, COPT1 shows stronger homology to yeast CTR2." YPR124W CTR1 7499355 AT5G59030.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt "This paper describes the cloning of A. thaliana COPT1 by complementation of yeast a ctr1 mutant; however, COPT1 shows stronger homology to yeast CTR2." YNL098C RAS2 7499408 ENSP00000348498|ENSP00000348498 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt "The authors looked at the suppression of ras, not complementation." YNL135C FPR1 7507662 ENSP00000262925 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Based on references referred to in this paper, the authors appear to be referring to FKBP1A (ENSP00000262925)." YML074C FPR3 7525596 FPR3 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YBR143C SUP45 7556078 eRF1 XENOPUS_LAEVIS SACCHAROMYCES_CEREVISIAE yes "In conjunction with Sup35p, yeast Sup45p acts as an antisupressor of SUP4; both human and X. laevis eRF1 can substitute for Sup45p in this regard." YBR143C SUP45 7556078 ENSP00000353741 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "In conjunction with Sup35p, yeast Sup45p acts as an antisupressor of SUP4; both human and X. laevis eRF1 can substitute for Sup45p in this regard." YGL008C PMA1 7559560 PMA2 NICOTIANA_PLUMBAGINIFOLIA SACCHAROMYCES_CEREVISIAE yes This paper shows that N. plumbaginifolia PMA2 allows growth of a yeast pma1 pma2 mutant. YPL036W PMA2 7559560 PMA2 NICOTIANA_PLUMBAGINIFOLIA SACCHAROMYCES_CEREVISIAE yes This paper shows that N. plumbaginifolia PMA2 allows growth of a yeast pma1 pma2 mutant. YGL008C PMA1 7580256 AT4G30190.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper shows that wild-type AHA2 does not complement a pma1 mutant, but certain deletion mutants of AHA2 do complement." YOL004W SIN3 7601471 ENSP00000353622/SIN3 MUS_MUSCULUS/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE no "The C-terminal half of S. cerevisiae SIN3 was replaced with mouse Sin3a (ENSP00000353622) in one chimeric protein, and in another chimeric protein the third PAH domain and surrounding core region of homology from yeast SIN3 was replaced with that of mouse Sin3a. Neither chimeric protein complemented a yeast sin3 null mutant." YKR050W TRK2 7621817 HAK1 SCHWANNIOMYCES_OCCIDENTALIS SACCHAROMYCES_CEREVISIAE yes HAK1 complements a trk1 mutant and a trk1 trk2 double mutant. YJL129C TRK1 7621817 HAK1 SCHWANNIOMYCES_OCCIDENTALIS SACCHAROMYCES_CEREVISIAE yes HAK1 complements a trk1 mutant and a trk1 trk2 double mutant. YFR052W RPN12 7621825 ENSP00000215071 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human p31 (ENSP00000215071) could not complement the temperature sensitive yeast nin1-1 mutant. YER171W RAD3 7629061 ENSP00000221481 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "ERCC2, the human homolog of yeast RAD3, is mutated in two different disorders, XPD and TTD. Wild type ERC22 and alleles with mutations associated with XPD complement yeast rad3 mutants." YMR186W HSC82 7637703 HSP83 TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE yes The T. cruzi HSP90 homolog complements a yeast hsp82 hsc82 double mutant. YPL240C HSP82 7637703 HSP83 TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE yes The T. cruzi HSP90 homolog complements a yeast hsp82 hsc82 double mutant. YMR186W HSC82 7637703 htpG ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no YPL240C HSP82 7637703 htpG ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no YMR186W HSC82 7637703 ENSP00000329390|ENSP00000341495|ENSP00000325875|ENSP00000360574|ENSP00000360609|ENSP00000360611|ENSP00000360617|ENSP00000360620|ENSP00000360709 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes The human HSP90Beta protein complements a yeast hsp82 hsc82 double mutant. YPL240C HSP82 7637703 ENSP00000329390|ENSP00000341495|ENSP00000325875|ENSP00000360574|ENSP00000360609|ENSP00000360611|ENSP00000360617|ENSP00000360620|ENSP00000360709 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes The human HSP90Beta protein complements a yeast hsp82 hsc82 double mutant. YBR154C RPB5 7651387 ENSP00000215587 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human hsRPB5 (ENSP00000215587) does not complement a yeast rpb5 null mutant. YHR143W-A RPC10 7651387 ENSP00000342889 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YHR143W-A RPC10 7651387 Sp10 alpha SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YOR210W RPB10 7651387 ENSP00000324124 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOR224C RPB8 7651387 ENSP00000296223 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPR187W RPO26 7651387 ENSP00000215960 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPR187W RPO26 7651387 CG1163-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YKR093W PTR2 7656990 AT2G02040.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YJL129C TRK1 7708709 AT5G46240.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana KAT1 complements a yeast trk1 trk2 double mutant. YKR050W TRK2 7708709 AT5G46240.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana KAT1 complements a yeast trk1 trk2 double mutant. YBL030C PET9 7736606 KIAAC KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes YHR008C SOD2 7753785 SOD2/FeSOD SACCHAROMYCES_CEREVISIAE/ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes "Expression of E. coli FeSOD complements a yeast sod2 mutant, but only if the E. coli protein is fused to the mitochondrial targeting sequence from yeast Sod2p." YOR117W RPT5 7754704 ENSP00000298852 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YHR135C YCK1 7759525 CK1 gamma 1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes "R. norvegicus (rat) CK1-gamma-1 and CK1-gamma-3 rescue a yeast yck1 yck2 double mutant, suggesting overlap of function between the yeast YCK proteins and the rat CK1 isoforms." YHR135C YCK1 7759525 CK1 gamma 3 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes "R. norvegicus (rat) CK1-gamma-1 and CK1-gamma-3 rescue a yeast yck1 yck2 double mutant, suggesting overlap of function between the yeast YCK proteins and the rat CK1 isoforms." YNL154C YCK2 7759525 CK1 gamma 1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes "R. norvegicus (rat) CK1-gamma-1 and CK1-gamma-3 rescue a yeast yck1 yck2 double mutant, suggesting overlap of function between the yeast YCK proteins and the rat CK1 isoforms." YNL154C YCK2 7759525 CK1 gamma 3 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes "R. norvegicus (rat) CK1-gamma-1 and CK1-gamma-3 rescue a yeast yck1 yck2 double mutant, suggesting overlap of function between the yeast YCK proteins and the rat CK1 isoforms." YDL195W SEC31 7760818 E1A ADENOVIRUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of a yeast sec31 null mutant by the adenovirus E1A protein. YHR164C DNA2 7760818 E1A ADENOVIRUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of a yeast dna2 null mutant by the adenovirus E1A protein. YPL111W CAR1 7770544 AT4G08900.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YMR297W PRC1 7785327 PRC1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no expt YNR052C POP2 7791755 ENSMUSP00000034012|ENSMUSP00000091254 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Both peptides map to the same mouse gene Cnot7 (NSMUSG00000031601). YDR129C SAC6 7799970 ENSP00000289290|ENSP00000348163 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Human T-fimbrin/T-plastin (ENSP00000289290, ENSP00000348163) can complement a yeast sac6 null mutant. T-fimbrin is a human fimbrin isoform." YDR129C SAC6 7799970 ENSP00000315757|ENSP00000368101 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Human L-fimbrin/L-plastin (ENSP00000315757, ENSP00000368101) can complement a yeast sac6 null mutant. L-fimbrin is a human fimbrin isoform." YDR129C SAC6 7799970 ENSP00000336831|ENSP00000348922 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "Human I-fimbrin/I-plastin (ENSP00000336831, ENSP00000348922) cannot complement a yeast sac6 null mutant. I-fimbrin is a human fimbrin isoform." YHR084W STE12 7802635 CPH1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes C. albicans CPH1 is also known as ACPR. YDL030W PRP9 7816610 PRP9/ENSP00000329527 SACCHAROMYCES_CEREVISIAE/HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt "This paper shows that a chimeric protein containing yeast PRP9 with the zinc finger region of human SF3A3 (ENSP00000329527 ) complements the temperature-sensitive phenotype of the yeast prp9-1 mutation, indicating that the essential function of the zinc finger-like region is evolutionarily conserved between the human and yeast proteins." YFL031W HAC1 7816617 HAC1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no expt S. cerevisiae HAC1 suppresses an S. pombe cdc10 mutant. Cdc10 is an S. pombe MBF transcription factor complex subunit. YGR240C PFK1 7825568 ENSP00000345771|ENSP00000352842 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human gene, ENSG00000152556." YMR205C PFK2 7825568 ENSP00000345771|ENSP00000352842 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human gene, ENSG00000152556." YJL129C TRK1 7835694 ENSMUSP00000001884 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes SKD3 complements a yeast trk1 trk2 double mutant. YKR050W TRK2 7835694 ENSMUSP00000001884 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes SKD3 complements a yeast trk1 trk2 double mutant. YGL048C RPT6 7870181 ENSP00000310572 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes ENSP00000310572 is referred to as PSMC5 and also TRIP1. YDL200C MGT1 7885384 ENSP00000302111 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGR170W PSD2 7890740 PSD2 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt This paper describes biochemical characterization of Psd2p in Sf-9 insect cell lysates. NONE YJR010W MET3 7920699 StMet3-1 SOLANUM_TUBEROSUM SACCHAROMYCES_CEREVISIAE yes YJR010W MET3 7920699 StMet3-2 SOLANUM_TUBEROSUM SACCHAROMYCES_CEREVISIAE yes YML074C FPR3 7925954 FPR3 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YOL081W IRA2 7935405 RAS GAP RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YER013W PRP22 7935475 ENSP00000262415 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows partial complementation of a yeast prp22 temperature-sensitive mutant by expression of human HRH1/DHX8 (ENSP00000262415). The results strongly suggest that HRH1 is a functional human homolog of the yeast Prp22 protein. YPR165W RHO1 7937763 ENSP00000265538 HOMO_SAPIENS/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE yes Intact human ENSP00000265538 (RHOA) does not confer full function in yeast rho1 null mutants. Full complementation of the yeast rho1 null mutant by human RHOA requires a 27-residue region of yeast RHO1 to be substituted into human RHOA. YMR199W CLN1 7958855 UNKNOWN:Cyclin E HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human cyclin E allows phosphorylation of human Rb in a yeast cln1 cln2 double mutant. YPL256C CLN2 7958855 UNKNOWN:Cyclin E HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human cyclin E allows phosphorylation of human Rb in a yeast cln1 cln2 double mutant. YAL040C CLN3 7958855 UNKNOWN:Cyclin E HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human cyclin E did not allow phosphorylation of human Rb in a yeast cln1 cln3 double mutant. YMR199W CLN1 7958855 UNKNOWN:Cyclin D1 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human cyclin E allows phosphorylation of human Rb in a yeast cln1 cln3 double mutant. YPL256C CLN2 7958855 UNKNOWN:Cyclin D1 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human cyclin E does not allow phosphorylation of human Rb in a yeast cln1 cln2 double mutant. YAL040C CLN3 7958855 UNKNOWN:Cyclin D1 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human cyclin E allows phosphorylation of human Rb in a yeast cln1 cln3 double mutant. YNL138W SRV2 7962207 ENSP00000229922 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows partial complementation of a yeast srv2 null mutant by human CAP2 (ENSP00000229922). YNL138W SRV2 7962207 ENSP00000344832 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows partial complementation of a yeast srv2 null mutant by human CAP1 (ENSP00000344832). YEL034W HYP2 7969034 Hypp DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes YEL034W HYP2 7969034 Hypp MEDICAGO_SATIVA SACCHAROMYCES_CEREVISIAE yes YEL034W HYP2 7969034 Hypp SULFOLOBUS_ACIDOCALDARIUS SACCHAROMYCES_CEREVISIAE no YEL034W HYP2 7969034 ENSP00000336702|ENSP00000336776|ENSP00000346541|ENSP00000347180 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YHR084W STE12 7992058 CPH1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YLR377C FBP1 8011172 FBP1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YGR155W CYS4 8022826 ENSP00000344460|ENSP00000352643 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All 3 peptides map to the same human gene, ENSG00000160200." YJR057W CDC8 8024690 ENSP00000304802|ENSP00000341279 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YEL021W URA3 8041358 AT3G54470.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YIL035C CKA1 8061317 AT5G47080.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper shows that A. thaliana CKB1 (AT5G47080.1) suppresses a yeast cka1 cka2-8 double mutant. YOR061W CKA2 8061317 AT5G47080.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper shows that A. thaliana CKB1 (AT5G47080.1) suppresses a yeast cka1 cka2-8 double mutant. YIL035C CKA1 8061317 AT4G17640.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper shows that A. thaliana CKB2 (AT4G17640.1) suppresses a yeast cka1 cka2-8 double mutant. YOR061W CKA2 8061317 AT4G17640.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper shows that A. thaliana CKB2 (AT4G17640.1) suppresses a yeast cka1 cka2-8 double mutant. YHR053C CUP1-1 8061521 AT1G07600.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis MT1 complements a yeast cup1 mutant. YHR055C CUP1-2 8061521 AT1G07600.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis MT1 complements a yeast cup1 mutant. YHR053C CUP1-1 8061521 AT3G09390.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis MT2 complements a yeast cup1 mutant. YHR055C CUP1-2 8061521 AT3G09390.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis MT2 complements a yeast cup1 mutant. YHR084W STE12 8083193 ACPR/STE12 CANDIDA_ALBICANS/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE no expt This paper describes a domain-swapping experiment used to analyze the function of C. albicans ACPR. YGR037C ACB1 8093000 ACB1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YGR286C BIO2 8117110 BIO2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes "In Escherichia coli, biotin synthase is encoded by the bioB gene." YOL096C COQ3 8125303 DHHB-MTase RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes R. norvegicus DHHB-MTase corresponds to GenBank acession id NP_062060. YDR477W SNF1 8164654 NPK5 NICOTIANA_TABACUM SACCHAROMYCES_CEREVISIAE yes YOR176W HEM15 8175771 AT5G26030.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YPR187W RPO26 8196653 RPB6 CRICETULUS_GRISEUS SACCHAROMYCES_CEREVISIAE yes YBL040C ERD2 8248265 AT1G29330.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YMR079W SEC14 8255295 SEC14 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS no expt This paper shows that yeast Sec14p can substitute biochemically for the non-homologous human gene PITP. ENSP00000316809 YIL034C CAP2 8257793 M106.5 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes "C. elegans cap-2 complements a yeast cap2 mutant, and coexpression of C. elegans cap-1 and cap-2 complements a yeast cap1 cap2 double mutant." YKL007W CAP1 8257793 D2024.6 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes "C. elegans cap-1 complements a yeast cap1 mutant, and coexpression of C. elegans cap-1 and cap-2 complements a yeast cap1 cap2 double mutant." YBR140C IRA1 8264648 ENSP00000351015|ENSP00000352435|ENSP00000348498 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All 3 peptides map to the same human gene, ensg00000196712." YMR186W HSC82 8289821 ENSP00000216281|ENSP00000335153 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human HSP90alpha complements a yeast hsc82 hsp82 double mutant. YPL240C HSP82 8289821 ENSP00000216281|ENSP00000335153 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human HSP90alpha complements a yeast hsc82 hsp82 double mutant. YFR053C HXK1 8321195 RAG5 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE no K. lactis RAG5 does not restore glucose repression in a yeast hxk1 hxk2 double mutant. YGL253W HXK2 8321195 RAG5 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE no K. lactis RAG5 does not restore glucose repression in a yeast hxk1 hxk2 double mutant. YGR240C PFK1 8326866 KLPFK1 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes K. lactis KLPFK1 and KLPFK2 each complement a yeast pfk1 pfk2 double mutant. YMR205C PFK2 8326866 KLPFK2 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes K. lactis KLPFK1 and KLPFK2 each complement a yeast pfk1 pfk2 double mutant. YER095W RAD51 8341671 ENSMUSP00000028795 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YGR240C PFK1 8344431 ENSP00000345771|ENSP00000352842 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human gene, ENSG00000152556." YGR240C PFK1 8344431 PFKA ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YMR205C PFK2 8344431 ENSP00000345771|ENSP00000352842 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human gene, ENSG00000152556." YMR205C PFK2 8344431 PFKA ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YGR074W SMD1 8346029 ENSP00000300413 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YBR195C MSI1 8350924 ENSP00000294520 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt "This paper shows that human RbAp48 (ENSP00000294520) shows homology to yeast MSI1. However, the authors did not use human RbAp48 to complement a yeast msi1 strain, instead they showed that human RbAp48 mimics the function of yeast Msi1p by suppressing the heat-shock sensitivity of a yeast ira1 strain and RAS2(Val19) strain." YBR248C HIS7 8366040 HIS7 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no Yeast His7p has the functions of both hisF and hisH from E. coli. hisA YBR248C HIS7 8366040 HIS7 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes Yeast His7p has the functions of both hisF and hisH from E. coli. hisF YBR248C HIS7 8366040 HIS7 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes Yeast His7p has the functions of both hisF and hisH from E. coli. hisH YJR104C SOD1 8367458 MT-I UNKNOWN:MONKEY SACCHAROMYCES_CEREVISIAE yes "Suppression, rather than complementation was probably demonstrated." YJR104C SOD1 8367458 MT-II UNKNOWN:MONKEY SACCHAROMYCES_CEREVISIAE yes YBR127C VMA2 8373794 subunit B BOS_TAURUS SACCHAROMYCES_CEREVISIAE yes YBR127C VMA2 8373794 subunit B CANDIDA_TROPICALIS SACCHAROMYCES_CEREVISIAE yes YCL043C PDI1 8385117 ENSMUSP00000076521 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that murine ERp72 (ENSMUSP00000076521) partially complements a yeast pdi1 null mutant. YCL043C PDI1 8385117 ENSMUSP00000026122 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that murine ERp59/PDI (ENSMUSP00000026122) partially complements a yeast pdi1 null mutant. YCL043C PDI1 8385117 ERp61 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no YGL248W PDE1 8389765 ENSP00000368730 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human HCP1 complements a yeast pde1 pde2 double mutant. YOR360C PDE2 8389765 ENSP00000368730 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human HCP1 complements a yeast pde1 pde2 double mutant. YNL088W TOP2 8393377 ENSP00000269577|ENSP00000342944|ENSP00000350217 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Expression of a recombinant human enzyme, in which the first 28 of the 1531 codons of human DNA topoisomerase II alpha were replaced by the first 5 codons of yeast DNA topoisomerase II, rescued the lethal phenotype of a thermal sensitive yeast top2 mutant." YDL052C SLC1 8408076 SLC1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes The corresponding E. coli gene complemented by S. cerevisiae SLC1 is named plsC. YDR337W MRPS28 8411168 MRPS28 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes S15 YNL135C FPR1 8413204 ENSP00000262925 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Based on references referred to in this paper, the authors appear to be referring to FKBP1A (ENSP00000262925)." YER171W RAD3 8413672 ENSP00000221481 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Only partial complementation was observed. ERC22 (XPD) complements the inviability phenotype, but not the DNA repair phenotype of a yeast rad3 mutant." YNL055C POR1 8420959 ENSP00000344876|ENSP00000301937|ENSP00000298468 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes All three peptides map to the same human gene VDAC2 (ENSG00000165637). YNL055C POR1 8420959 ENSP00000265333 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes ENSP00000265333 is encoded by the human gene VDAC1 (ENSG00000073905). YBR049C REB1 8423784 REB1 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes YGL008C PMA1 8425607 AT4G30190.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes This paper shows that a truncated form of A. thaliana AHA2 complements a yeast pma1 mutant. YBL105C PKC1 8429022 PKC-alpha BOS_TAURUS SACCHAROMYCES_CEREVISIAE no expt YDR226W ADK1 8439550 ADK1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YLL050C COF1 8440472 Cof SUS_SCROFA SACCHAROMYCES_CEREVISIAE yes YBR082C UBC4 8441382 M7.1 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes "C. elegans M7.1 (ubc-2) partially complemented a yeast ubc4 ubc5 double mutant, resulting in a ubc5 phenotype that suggested that ubc-2 can functionally subsitute for yeast UBC4." YMR072W ABF2 8441424 ENSP00000320311 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YHR053C CUP1-1 8444189 CUP1-1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt Yeast Cup1p was characterized biochemically in E. coli. NONE YHR055C CUP1-2 8444189 CUP1-2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt Yeast Cup1p was characterized biochemically in E. coli. NONE YGR037C ACB1 8452523 ACBP BOS_TAURUS SACCHAROMYCES_CEREVISIAE no expt YBR126C TPS1 8467996 TPS1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes otsA YEL021W URA3 8500761 PYR5-6 DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes DdPYR5-6 encodes a bifunctional enzyme that complements both the ura3 and ura5 mutations in yeast. YML106W URA5 8500761 PYR5-6 DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes DdPYR5-6 encodes a bifunctional enzyme that complements both the ura3 and ura5 mutations in yeast. YDL014W NOP1 8508778 ENSP00000221801 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that human fibrillarin (ENSP00000221801) partially complements a yeast nop1 null mutant, but yeast nop1 null mutants complemented by human fibrillarin are temperature sensitive for growth and impaired in prerRNA processing." YDL126C CDC48 8521820 AT3G09840.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YBL079W NUP170 8522578 NUP155 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YGL070C RPB9 8524256 ENSP00000221859 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Expression of human ENSP00000221859 (hsRPB9) on a high-copy-number plasmid, but not a low-copy-number plasmid, restored growth of the yeast rpb9 null mutant at high temperatures." YOR210W RPB10 8524256 ENSP00000324124 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOR224C RPB8 8524256 ENSP00000296223 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGR155W CYS4 8528202 ENSP00000344460|ENSP00000352643 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YBR154C RPB5 8524256 ENSP00000215587 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human ENSP00000215587 (hsRPB5) did not complement a yeast rpb5 null mutant even when human hsRPB5 was expressed on a high-copy-number plasmid. YJL129C TRK1 8534918 gpIRK1 CAVIA_PORCELLUS SACCHAROMYCES_CEREVISIAE yes gpIRK1 complements a yeast trk1 trk2 double mutant. YKR050W TRK2 8534918 gpIRK1 CAVIA_PORCELLUS SACCHAROMYCES_CEREVISIAE yes gpIRK1 complements a yeast trk1 trk2 double mutant. YAL040C CLN3 8535138 cycMs4 MEDICAGO_SATIVA SACCHAROMYCES_CEREVISIAE yes Alfalfa cycMs4 complements a yeast cln1 cln2 cln3 triple mutant. YMR199W CLN1 8535138 cycMs4 MEDICAGO_SATIVA SACCHAROMYCES_CEREVISIAE yes Alfalfa cycMs4 complements a yeast cln1 cln2 cln3 triple mutant. YPL256C CLN2 8535138 cycMs4 MEDICAGO_SATIVA SACCHAROMYCES_CEREVISIAE yes Alfalfa cycMs4 complements a yeast cln1 cln2 cln3 triple mutant. YOR231W MKK1 8544826 HST7 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE no expt YPL140C MKK2 8544826 HST7 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE no expt YJL128C PBS2 8544826 HST7 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE no expt YDL159W STE7 8544826 HST7 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YJL129C TRK1 8550001 UNKNOWN:KAT1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana KAT1 complements a yeast trk1 trk2 double mutant. YKR050W TRK2 8550001 UNKNOWN:KAT1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana KAT1 complements a yeast trk1 trk2 double mutant. YJL129C TRK1 8550001 UNKNOWN:AKT1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR202W HIS3 8590485 HIS3 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes his5-303 YBR115C LYS2 8590485 LYS2 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes lys1-131 YKL182W FAS1 8595667 FAS RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt YPL231W FAS2 8595667 FAS RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt YJR066W TOR1 8595879 RAFT1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no "Rat RAFT1 does not complement a yeast tor1 mutant, but a RAFT1-TOR1 chimera does." YKL203C TOR2 8595879 RAFT1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no "Rat RAFT1 does not complement a yeast tor2 mutant, but a RAFT1-TOR2 chimera does." YKL209C STE6 8597596 AT4G08500.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt "This Arabidopsis cDNA suppresses a yeast ste6 mutant, but the genes are not homologous." YHL007C STE20 8597596 AT4G08500.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YLR362W STE11 8597596 AT4G08500.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGR040W KSS1 8597596 AT4G08500.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This Arabidopsis cDNA fails to suppress a yeast fus3 kss1 double mutant. YBL016W FUS3 8597596 AT4G08500.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This Arabidopsis cDNA fails to suppress a yeast fus3 kss1 double mutant. YHR072W ERG7 8604986 SPU41368 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes The S. pombe lanosterol synthase cloned in this paper has the Genbank id U41368. YLR377C FBP1 8606152 FbPase ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no expt YHR037W PUT2 8621661 ENSP00000290597|ENSP00000336944 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes ENSP00000290597 and ENSP00000336944 are identical. YGL055W OLE1 8632982 NONE HISTOPLASMA_CAPSULATUM SACCHAROMYCES_CEREVISIAE no expt "This paper analyzes the expression of yeast OLE1 when the promoter, not the open reading frame, is replaced with the OLE1 promoter from Histoplasma capsulatum." YAL016W TPD3 8641277 AT1G25490.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YMR058W FET3 8643627 AT4G19690.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt "IRT1 was cloned by transforming an Arabidopsis library into fet3 fet4 yeast, but IRT1 is more closely related to yeast ZRT1 and ZRT2 and shows no similarity to FET3 or FET4." YMR319C FET4 8643627 AT4G19690.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt "IRT1 was cloned by transforming an Arabidopsis library into fet3 fet4 yeast, but IRT1 is more closely related to yeast ZRT1 and ZRT2 and shows no similarity to FET3 or FET4." YGR063C SPT4 8649394 ENSP00000225504 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YER023W PRO3 8654976 PRO3 ZALERION_ARBORICOLA SACCHAROMYCES_CEREVISIAE yes YKL190W CNB1 8662738 At1g27730.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt Arabidopsis At1g27730.1 suppresses the salt-sensitive phenotype of yeast calcineurin cnb1 mutants. YLR433C CNA1 8662738 AT1G06040.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt Arabidopsis AT1G06040.1 suppresses the salt-sensitive phenotype of yeast calcineurin cna1 cmp2 mutants. YML057W CMP2 8662738 AT1G06040.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt Arabidopsis AT1G06040.1 suppresses the salt-sensitive phenotype of yeast calcineurin cna1 cmp2 mutants. YER021W RPN3 8668124 CG10484-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes "This paper shows that Dox-A2 complements an rpn3 mutant at the permissive temperature but, at the restrictive temperature, has the same phenotype as a truncated Rpn3p." YDL064W UBC9 8668125 ENSP00000219558|ENSP00000324897|ENSP00000344402|ENSP00000345942 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All four peptides map to the same gene ENSG00000103275O (UBE21, hUBC9). Overexpression of human hUBC9 partially complements an S. cerevisiae ubc9 temperature-sensitive mutation, indicating that the UBC9 gene family is functionally conserved." YPR183W DPM1 8670162 Dol-P-Man synthase TRYPANOSOMA_BRUCEI_BRUCEI SACCHAROMYCES_CEREVISIAE yes YLR452C SST2 8673468 ENSP00000235382|ENSP00000356427 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YBL030C PET9 8675018 ANC SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YDR376W ARH1 8681964 adrenodoxin BOS_TAURUS SACCHAROMYCES_CEREVISIAE no expt YPL252C YAH1 8681964 NADPH adrenodoxin reductase BOS_TAURUS SACCHAROMYCES_CEREVISIAE no expt YER009W NTF2 8702493 ENSP00000219169 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YKL209C STE6 8702500 ENSMUSP00000041204|ENSMUSP00000088389 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no expt YOL096C COQ3 8703953 ubiG ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes "The E. coli ubiG gene is able to complement the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence." YKL209C STE6 8706740 HLYB ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no YGL048C RPT6 8710853 ENSMUSP00000021049 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YKL152C GPM1 8765231 PGAM SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE no expt Expression of PGAM was carried out for biochemical studies only. YHR027C RPN1 8774743 ENSP00000310129 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YER165W PAB1 8776896 AT1G71770.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana PAB5 (AT1G71770.1) partially complements a yeast pab1 null mutant. YCL018W LEU2 8781173 leu2A ASPERGILLUS_NIGER SACCHAROMYCES_CEREVISIAE yes This paper demonstrates complementation of a yeast leu2 mutant by a plasmid carrying 2 genes (leu2A and leu2B) from A. niger. YCL018W LEU2 8781173 leu2B ASPERGILLUS_NIGER SACCHAROMYCES_CEREVISIAE yes This paper demonstrates complementation of a yeast leu2 mutant by a plasmid carrying 2 genes (leu2A and leu2B) from A. niger. YOR212W STE4 8789259 UNKNOWN:GBeta1 UNKNOWN:MAMMALIAN SACCHAROMYCES_CEREVISIAE no "A mammalian G protein Beta1 subunit from an unspecified species was unable to complement a yeast ste4 mutant, even when co-transfected with either a G Gamma1 or G Gamma2 subunit (STE18 homolog)." YMR202W ERG2 8798407 ENSMUSP00000033509 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YMR202W ERG2 8798407 ENSP00000276096 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOR232W MGE1 8798629 MGE1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes the biochemical characterization of yeast Mge1p in E. coli. GrpE YIL075C RPN2 8816993 ENSP00000309474 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that human p112 cDNA (ENSP00000309474) suppressed the growth defect at high temperature of an rpn2 mutant, indicating that p112 is a functional homologue of yeast Rpn2p." YPR165W RHO1 8846785 ENSP00000265538 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper shows that when yeast RHO1 is replaced with human RhoA (ENSP00000265538) it results in a recessive temperature-sensitive growth phenotype. This paper describes how a dominant suppressor mutant was isolated from this strain. YGL008C PMA1 8852338 PMA1 CANDIDA_ALBICANS/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE no expt This paper describes a domain-swapping experiment used to analyze the function of C. albicans PMA1. YMR080C NAM7 8855285 ENSP00000262803 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "This paper shows that full-length human RENT1 does not complement a yeast nam7 (aka upf1) mutant, but a chimeric human/yeast protein does." YMR080C NAM7 8855285 ENSP00000262803/YMR080C HOMO_SAPIENS/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE yes "This paper shows that full-length human RENT1 does not complement a yeast nam7 (aka upf1) mutant, but a chimeric human/yeast protein does." YFL018C LPD1 8894701 ENSP00000205402 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDL006W PTC1 8898906 AT4G26080.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes This paper shows that a truncated form of A. thaliana ABI1 complements a yeast ptc1 mutant. YJL041W NSP1 8918934 NSP1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes a biochemical analysis of yeast Nsp1p expressed in E. coli. NONE YML123C PHO84 8927627 AT5G43350.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YML123C PHO84 8927627 AT2G38940.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YPR165W RHO1 8947028 ENSP00000265538 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJL042W MHP1 8947554 CG1483-PA|CG1483-PB DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE no expt "This paper shows that haploid yeast mhpl-A1 cells are partially rescued by the expression of D. melanogaster 205K MAP (CG1483-PA, CG1483-PB), and that 205K MAP and Mhplp share some functional similarity. Suppression, rather than complementation was probably demonstrated." YOL127W RPL25 8947565 RL23a RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YPR005C HAL1 8954095 beta-globin RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of the hal1 null mutant phenotype by rat beta-globin. YPR005C HAL1 8954095 lambda-crystallin RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of the hal1 null mutant phenotype by rat lambda-crystallin. YPR005C HAL1 8954095 androgen-regulated protein RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of the hal1 null mutant phenotype by rat androgen-regulated protein. YPR005C HAL1 8954095 mitochondrial cytochrome b RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of the hal1 null mutant phenotype by rat mitochondrial cytochrome b. YPR005C HAL1 8954095 homolog of infant brain cDNA RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of the hal1 null mutant phenotype by a rat homolog of infant brain cDNA. YPR005C HAL1 8954095 salt-tolerant protein RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt This paper shows suppression of the hal1 null mutant phenotype by rat salt-tolerant protein (STP). YHR027C RPN1 8970163 ENSP00000310129 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGR252W GCN5 8972232 ENSP00000225916 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "Human GCN5 (ENSP00000225916) does not complement a yeast gcn5 null mutant, but a yeast-human chimera containing the putative HAT domain of human GCN5 fused to the remainder of yeast GCN5 does complement a yeast gcn5 mutant for growth and transcriptional activation." YFL038C YPT1 8973313 Piypt1 PHYTOPHTHORA_INFESTANS SACCHAROMYCES_CEREVISIAE yes YDR331W GPI8 8978684 ENSP00000271047|ENSP00000352041|ENSP00000359846|ENSP00000359848|ENSP00000359849 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGR007W MUQ1 8982874 MUQ1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YKL149C DBR1 9001235 C55B7.8 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes YKL149C DBR1 9001235 dbr1 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YLR142W PUT1 9003320 AT5G38710.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YDL047W SIT4 9013334 ENSP00000238362 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YER021W RPN3 9017604 ENSP00000264639 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that a truncated form of ENSP00000264639 missing the first 150 aa can complement a yeast rpn3 mutant, although full-length ENSP00000264639 cannot." YKL209C STE6 9020050 ENSMUSP00000041204|ENSMUSP00000088389 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YDR397C NCB2 9023340 ENSP00000236164|ENSP00000359290|ENSP00000359295 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human Dr1 complements a yeast ncb2 (aka ydr1) mutant. YER159C BUR6 9023340 ENSP00000307850|ENSP00000366190 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Human DRAP1 complements a yeast bur6 mutant, but only when yeast ncb2 is also replaced with human Dr1." YGL055W OLE1 9031643 P-OLE1 PICHIA_ANGUSTA SACCHAROMYCES_CEREVISIAE yes YPR005C HAL1 9032977 HAL1 SACCHAROMYCES_CEREVISIAE CUCUMIS_MELO no expt This paper shows that the heterologous expression of yeast HAL1 in melon plants improves their salt tolerance. YNL055C POR1 9045642 Tavdac1 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes Wheat Tavdac1 complements a yeast por1 mutant indicating that it functions as a voltage-dependent anion channel (VDAC). YNL055C POR1 9045642 Tavdac2 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes Wheat Tavdac2 complements a yeast por1 mutant indicating that it functions as a voltage-dependent anion channel (VDAC). YNL055C POR1 9045642 Tavdac3 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes Wheat Tavdac3 complements a yeast por1 mutant indicating that it functions as a voltage-dependent anion channel (VDAC). YLL009C COX17 9050918 ENSP00000261070 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOR210W RPB10 9054344 ABC10beta SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YOR014W RTS1 9079645 B'alpha ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that expression of the rabbit B'alpha subunit of protein phosphatase 2A (PP2A) complements a yeast temperature-sensitive rts1 mutant. YOR014W RTS1 9079645 B'gamma ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that expression of the rabbit B'gamma isoform of the B-subunit of protein phosphatase 2A (PP2A) partially complements a yeast temperature-sensitive rts1 mutant. YBR276C PPS1 9083070 PPS1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YML123C PHO84 9090882 StPT1 SOLANUM_TUBEROSUM SACCHAROMYCES_CEREVISIAE yes YML123C PHO84 9090882 StPT2 SOLANUM_TUBEROSUM SACCHAROMYCES_CEREVISIAE yes YER136W GDI1 9091322 AT2G44100.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGR040W KSS1 9099733 KFR1 TRYPANOSOMA_BRUCEI SACCHAROMYCES_CEREVISIAE no T. brucei KFR1 failed to complement a yeast kss1 fus3 double mutant. YBL016W FUS3 9099733 KFR1 TRYPANOSOMA_BRUCEI SACCHAROMYCES_CEREVISIAE no T. brucei KFR1 failed to complement a yeast kss1 fus3 double mutant. YOR236W DFR1 9108546 PFD0830w PLASMODIUM_FALCIPARUM SACCHAROMYCES_CEREVISIAE yes YBR029C CDS1 9115637 ENSP00000295887 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDL090C RAM1 9121446 LeFTA LYCOPERSICON_ESCULENTUM SACCHAROMYCES_CEREVISIAE yes "Yeast RAM1 encodes the beta subunit of the CAAX farnesyltransferase (FTase), and although this paper shows that a yeast ram1 null mutant could not be complemented by the tomato FTase beta subunit alone, co-expression of the tomato FTase alpha (LeFTA) and beta (LeFTB) subunits could rescue a yeast ram1 mutant. " YDL090C RAM1 9121446 LeFTB LYCOPERSICON_ESCULENTUM SACCHAROMYCES_CEREVISIAE yes "Yeast RAM1 encodes the beta subunit of the CAAX farnesyltransferase (FTase), and although this paper shows that a yeast ram1 null mutant could not be complemented by the tomato FTase beta subunit alone, co-expression of the tomato FTase alpha (LeFTA) and beta (LeFTB) subunits could rescue a yeast ram1 mutant." YMR001C CDC5 9154840 ENSMUSP00000033154 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Mouse Plk1 (ENSMUSP00000033154) is a functional homolog of yeast CDC5 that complements the cell division defect associated with the yeast cdc5-1 mutation. YBR049C REB1 9159465 NONE SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YGR175C ERG1 9161422 SE CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE no expt YLR229C CDC42 9197407 CG12530-PA|CG12530-PB DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes "This paper shows that D. melanogaster CDC42 (CG12530-PA, CG12530-PB) compelments a temperature-sensitive cdc42-1 yeast mutant and that they are functional homologs." YPR165W RHO1 9197407 ENSP00000265538 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPR165W RHO1 9197407 CG8416-PA|CG8416-PB|CG8416-PC|CG8416-PD|CG8416-PE|CG8416-PF|CG8416-PG DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YJR104C SOD1 9199172 UNKNOWN:Bcl-2 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt Human Bcl-2 suppresses a yeast sod1 mutation. YKL196C YKT6 9211930 ENSP00000223369 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPR183W DPM1 9223280 DPM1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes This paper shows that human DPM1 also complements S. pombe dpm1+. dpm1+ YPR183W DPM1 9223280 dpm1+ SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE no YPR183W DPM1 9223280 ENSP00000001585 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YGL006W PMC1 9238019 AT1G07810.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper shows that A. thaliana AT1G07810.1 suppresses the phenotype associated with the yeast triple mutant (pmr1 pmc1 cnb1) which is deficient in golgi and vacuolar Ca(2+) pumps and calcineurin B. YGL167C PMR1 9238019 AT1G07810.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper shows that A. thaliana AT1G07810.1 complements a yeast pmr1 mutant, indicating that it functions as a Ca(2+) pump, and also suppresses a triple mutant (pmr1 pmc1 cnb 1) deficient in Golgi and vacuolar Ca(2+) pumps and calcineurin B." YKL190W CNB1 9238019 AT1G07810.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper shows that A. thaliana AT1G07810.1 suppresses the phenotype associated with the yeast triple mutant (pmr1 pmc1 cnb 1) which is deficient in Golgi and vacuolar Ca(2+) pumps and calcineurin B. YDR040C ENA1 9238019 AT1G07810.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no This paper shows that A. thaliana AT1G07810.1 does not complement a yeast ena1 (alias pmr2) null mutant and does not function as a Na+ and Li+ efflux pump. YBR088C POL30 9247551 PCNA BRASSICA_NAPUS SACCHAROMYCES_CEREVISIAE yes YDR270W CCC2 9261163 ENSP00000242839|ENSP00000342559 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Both peptides map to the same human gene ENSG00000123191. YPL218W SAR1 9275220 SAR1 SACCHAROMYCES_CEREVISIAE MYXOCOCCUS_XANTHUS yes MglA YAR007C RFA1 9275237 Os-RPA1/RPA1 ORYZA_SATIVA/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE yes This paper shows that a chimeric rice/yeast RPA1 can complement a yeast rfa1 mutation. YGL008C PMA1 9282738 PMA1 SCHIZOSACCHAROMYCES_POMBE/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE yes A chimeric S. pombe/S. cerevisiae PMA1 restores partial function to an S. cerevisiae pma1 pma2 strain. YPL036W PMA2 9282738 PMA1 SCHIZOSACCHAROMYCES_POMBE/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE yes A chimeric S. pombe/S. cerevisiae PMA1 restores partial function to an S. cerevisiae pma1 pma2 strain. YHR143W-A RPC10 9290054 Rpc10 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YML008C ERG6 9290641 ESMT1 ZEA_MAYS SACCHAROMYCES_CEREVISIAE yes YEL021W URA3 9299778 URA3 SACCHAROMYCES_CEREVISIAE SCHWANNIOMYCES_ALLUVIUS yes This unidentified ura- strain is complemented by S. cerevisiae URA3 UNKNOWN YER148W SPT15 9303315 SPT15 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YCR073C SSK22 9305639 ENSP00000265125|ENSP00000297332 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Although human MTK1 (ENSP00000265125, ENSP00000297332) was cloned by functional complementation of the yeast ssk2 ssk22 sho1 triple mutant, MTK1 shows stronger homology to yeast Ssk2/Ssk22 and MTK1 can functionally replace Ssk2 and Ssk22 in the yeast HOG MAP kinase pathway. " YNR031C SSK2 9305639 ENSP00000265125|ENSP00000297332 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Although human MTK1 (ENSP00000265125, ENSP00000297332) was cloned by functional complementation of the yeast ssk2 ssk22 sho1 triple mutant, MTK1 shows stronger homology to yeast Ssk2/Ssk22 and MTK1 can functionally replace Ssk2 and Ssk22 in the yeast HOG MAP kinase pathway. " YCL001W RER1 9309388 ENSP00000302088 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YFL016C MDJ1 9324254 MDJ1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes "This paper describes a biochemical and genetic analysis of yeast Mdj1p, Ssc1p, and Mge1p in E. coli." DnaJ YJR045C SSC1 9324254 SSC1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no "This paper describes a biochemical and genetic analysis of yeast Ssc1p, Mdj1p, and Mge1p in E. coli." DnaK YOR232W MGE1 9324254 MGE1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes "This paper describes a biochemical and genetic analysis of yeast Mge1p, Mdj1p, and Ssc1p in E. coli." GrpE YJL129C TRK1 9350997 AT2G30070.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes ATKT1 complements a yeast trk1 trk2 double mutant. YKR050W TRK2 9350997 AT2G30070.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes ATKT1 complements a yeast trk1 trk2 double mutant. YJL129C TRK1 9350997 AT2G40540.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes ATKT2 complements a yeast trk1 trk2 double mutant. YKR050W TRK2 9350997 AT2G40540.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes ATKT2 complements a yeast trk1 trk2 double mutant. YMR272C SCS7 9353282 AT2G34770.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "The A. thaliana FAH1 homolog (AT2G34770.1), which does not contain the cytochrome b5 domain, partially complemented a yeast scs7 null mutant. The A. thaliana homolog plays a similar role in very long chain fatty acid hydroxylation, but apparently uses an alternate electron donor." YMR001C CDC5 9353331 ENSP00000310097 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human Prk (ENSP00000310097) shows homology to yeast CDC5 and is able to complement a yeast cdc5 temperature-sensitive mutant. YDR270W CCC2 9354393 Y76A2A.2 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes YFR028C CDC14 9367992 ENSP00000336739|ENSP00000354916 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YKL184W SPE1 9371082 ODC HAEMONCHUS_CONTORTUS SACCHAROMYCES_CEREVISIAE yes YGL058W RAD6 9371881 AT2G02760.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis ATUBC2 partially complementats a yeast rad6 mutant. YHR069C RRP4 9390555 ENSP00000253010 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Human RRP4 (ENSP00000253010) complements a yeast rrp4-1 mutant that has a temperature-sensitive growth phenotype, but not a yeast rrp4 null mutant. However, no other yeast protein is homologous to Rrp4p and a genetic screen did not identify any multicopy extragenic suppressors of the rrp4-1 mutation. Therefore, the authors concluded that human RRP4 encodes a functional homolog of yeast Rrp4p." YKL184W SPE1 9392083 SPE1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YML121W GTR1 9394008 ENSP00000286334 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This papers shows that human RRAGA (ENSP00000286334) is 52% identical to yeast GTR1 and complements a yeast cold-sensitive gtr1-11 mutant, indicating that the human and yeast proteins are functional homologs." YML121W GTR1 9394008 ENSP00000262850|ENSP00000262851 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human RRAGB gene (ENSG00000083750). This papers shows that human RRAGB is 52% identical to yeast GTR1 and complements a yeast cold-sensitive gtr1-11 mutant, indicating that the human and yeast proteins are functional homologs." YJL166W QCR8 9395324 QCR8 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes S. pombe QCR8 partially complements the respiratory-deficient phenotype of a S. cerevisiae qcr8 null mutant. YJL166W QCR8 9395324 QCR8 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes K. lactis QCR8 partially complements the respiratory-deficient phenotype of a S. cerevisiae qcr8 null mutant. YJL166W QCR8 9395324 QCR8 BOS_TAURUS SACCHAROMYCES_CEREVISIAE no Bovine QCR8 does not complement the respiratory-deficient phenotype of a S. cerevisiae qcr8 null mutant. YML123C PHO84 9425684 MtPT1 MEDICAGO_TRUNCATULA SACCHAROMYCES_CEREVISIAE yes YBL105C PKC1 9427282 ENSP00000306124 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJL095W BCK1 9427282 ENSP00000306124 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YMR062C ECM40 9428669 ECM40 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt "Overexpression of yeast ECM40 complements an E. coli argA mutation affecting acetylglutamate synthase, thereby demonstrating that aside from from functioning as an ornithine acetyltransferase, ECM40 also has some acetylglutamate synthase activity." YDR040C ENA1 9430707 ENA1 SCHWANNIOMYCES_OCCIDENTALIS SACCHAROMYCES_CEREVISIAE yes YNL259C ATX1 9430722 ENSP00000316854 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Overexpression of Atx1p suppresses the lysine auxotrophy of sod1 yeast, as does expression of human ATOX1 (HAH1)." YMR197C VTI1 9446565 ENSP00000281221 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDR270W CCC2 9452509 ENSP00000343026|ENSP00000345728 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human gene, ENSG00000165240." YER136W GDI1 9461425 AT3G59920.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YER136W GDI1 9461425 AT2G44100.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGR078C PAC10 9463374 ENSP00000286428|ENSP00000358467 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR200W YKE2 9463374 ENSMUSP00000025163 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YDR294C DPL1 9464245 ENSMUSP00000090155 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YHR042W NCP1 9468503 UNKNOWN:CYP51 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper describes the biochemical characterization of human CYP51 expressed in and NCP1 strain. YGL048C RPT6 9469929 CG1489-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YLR175W CBF5 9483794 KLCBF5 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes YDR477W SNF1 9484448 SNFL1 SORGHUM_BICOLOR SACCHAROMYCES_CEREVISIAE no YGL130W CEG1 9512541 ENSP00000339517 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that the 597aa Hce1p complements a yeast ceg1 mutant, but that the shorter peptides Hce1ap and Hce1bp do not." YGL130W CEG1 9512541 ENSP00000265607 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "ENSP00000265607 is the 574aa Hce1ap described in this paper. A shorter peptide, Hce1b, also fails to complement a yeast ceg1 mutant but is not currently listed in Ensembl." YPL228W CET1 9512541 ENSP00000339517 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that the 597aa Hce1p complements a yeast cet1 mutant, but that the shorter peptides Hce1ap and Hce1bp do not." YPL228W CET1 9512541 ENSP00000265607 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "ENSP00000265607 is the 574aa Hce1ap described in this paper. A shorter peptide, Hce1b, also fails to complement a yeast cet1 mutant but is not currently listed in Ensembl." YDL140C RPO21 9524248 ENSMUSP00000050771|ENSMUSP00000071200 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YHR007C ERG11 9527767 CYP51A1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YGL006W PMC1 9528801 tca1 TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE yes "T. cruzi tca1 complements a yeast pmc1 vcx1 mutant and exhibits the same phenotype as a yeast vcx1 mutant alone with wildtype PMC1, suggesting that tca1 functionally complements pmc1." YDL128W VCX1 9528801 tca1 TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE no "T. cruzi tca1 complements a yeast pmc1 vcx1 mutant and exhibits the same phenotype as a yeast vcx1 mutant alone with wildtype PMC1, suggesting that tca1 functionally complements pmc1." YPR183W DPM1 9535917 DPM1 SACCHAROMYCES_CEREVISIAE MUS_MUSCULUS yes This paper also shows that human DPM1 complements the mouse mutation. ENSMUSP00000029055 YPR183W DPM1 9535917 DPM1 SACCHAROMYCES_CEREVISIAE CRICETULUS_GRISEUS yes This paper also shows that human DPM1 does not complement mutation of DPM1 in CHO cells. DPM1 YFL029C CAK1 9560221 AT4G28980.1|AT4G28980.2 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes AT4G28980.1 and AT4G28980.2 are identical peptides and are 1 aa longer than the sequence published in this paper. YDL200C MGT1 9573177 DNA polymerase beta RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt Rat DNA polymerase beta was expressed in a yeast mgt1 mutant. YER142C MAG1 9573177 DNA polymerase beta RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt Rat DNA polymerase beta was expressed in a yeast mag1 mutant. YKL114C APN1 9573177 DNA polymerase beta RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt Rat DNA polymerase beta was expressed in a yeast apn1 mutant. YKL024C URA6 9576794 AT5G26667.2 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "A nearly identical peptide, AT5G26667.1, is also in the same OrthoMCL family." YGL142C GPI10 9576863 ENSP00000164305 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJL093C TOK1 9579518 TOK1 SACCHAROMYCES_CEREVISIAE XENOPUS_LAEVIS no expt This is a biochemical study of Tok1p heterologously expressed in Xenopus oocytes. NONE YDL235C YPD1 9582274 YPD1 SACCHAROMYCES_CEREVISIAE DICTYOSTELIUM_DISCOIDEUM yes YNL001W DOM34 9584085 CG3959-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YNL232W CSL4 9584087 ENSP00000306711 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "According to this paper, human CSL4 (ENSP00000306711) partially complements a yeast csl4 null mutant." YKL117W SBA1 9584173 ENSP00000262033 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR012W CLU1 9601101 CLU1 SACCHAROMYCES_CEREVISIAE DICTYOSTELIUM_DISCOIDEUM yes The D. discoideum cluA gene was shown to be a functional homolog of yeast CLU1. YDR503C LPP1 9603941 LPP1 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt This paper describes biochemical characterization of Lpp1p in Sf-9 insect cells. YEL059C-A SOM1 9604886 SOM1 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes YKR050W TRK2 9614085 HAK1 SCHWANNIOMYCES_OCCIDENTALIS SACCHAROMYCES_CEREVISIAE yes HAK1 complements a trk1 trk2 double mutant. YJL129C TRK1 9614085 HAK1 SCHWANNIOMYCES_OCCIDENTALIS SACCHAROMYCES_CEREVISIAE yes HAK1 complements a trk1 trk2 double mutant. YKR050W TRK2 9614085 HKT1 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes HKT1 complements a trk1 trk2 double mutant. YJL129C TRK1 9614085 HKT1 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes HKT1 complements a trk1 trk2 double mutant. YDR410C STE14 9614111 ENSP00000313340 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows partial complementation of a yeast ste14 mutant by human ICMT (ENSP00000313340). YJL059W YHC3 9618513 ENSP00000353116|ENSP00000353116|ENSP00000346650 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "ENSP00000350523, ENSP00000353116, ENSP00000346650 map to the human CLN3 gene (ENSG00000188603)." YDL132W CDC53 9636170 ENSP00000326804 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDL006W PTC1 9649525 T19C3.8 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes YGL040C HEM2 9654753 HEM2 CANDIDA_GLABRATA SACCHAROMYCES_CEREVISIAE yes YBR082C UBC4 9658002 UBC1Cg COLLETOTRICHUM_GLOEOSPORIOIDES SACCHAROMYCES_CEREVISIAE yes C. gloeosporioides UBC1Cg complements a yeast ubc4 ubc5 double mutant. YDR059C UBC5 9658002 UBC1Cg COLLETOTRICHUM_GLOEOSPORIOIDES SACCHAROMYCES_CEREVISIAE yes C. gloeosporioides UBC1Cg complements a yeast ubc4 ubc5 double mutant. YMR190C SGS1 9671747 ENSP00000347232|ENSP00000349859 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Mutation of SGS1 suppresses the slow-growth phenotype of top3 mutants; this paper shows that the Bloom's syndrome gene can restore the slow-growth phenotype of sgs1 top3 double mutants. Both complementing peptides map to the same human gene, ENSG00000197299." YMR190C SGS1 9671747 ENSP00000298139 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YJR006W HYS2 9677405 HYS2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes co-expression of yeast Pol31p and Pol32p in E. coli. NONE YJR043C POL32 9677405 POL32 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes co-expression of yeast Pol31p and Pol32p in E. coli. NONE YOL139C CDC33 9680993 AT4G18040.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YDR135C YCF1 9681016 AT3G13080.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis ATMRP3 partially complements a yeast ycf1 mutant. YML120C NDI1 9689052 NDI1 SACCHAROMYCES_CEREVISIAE CRICETULUS_GRISEUS no expt This paper shows that functional expression of NDI1 in a CHO cell line lacking complex I restores NADH oxidase activity. COMPLEX I YKL190W CNB1 9689141 CNB1 SACCHAROMYCES_CEREVISIAE NICOTIANA_TABACUM no expt YML057W CMP2 9689141 CMP2 SACCHAROMYCES_CEREVISIAE NICOTIANA_TABACUM no expt YBL106C SRO77 9691031 ENSP00000321537|ENSP00000321993 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human LLGL complements a yeast sro7 sro77 mutant. YPR032W SRO7 9691031 ENSP00000321537|ENSP00000321993 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human LLGL complements a yeast sro7 sro77 mutant. YPL218W SAR1 9697342 AT1G56330.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YPL218W SAR1 9697342 NtSAR1 NICOTIANA_TABACUM SACCHAROMYCES_CEREVISIAE yes YHR037W PUT2 9700195 ENSP00000290597|ENSP00000336944 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes ENSP00000290597 and ENSP00000336944 are identical. YNL259C ATX1 9701579 AT3G56240.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGL087C MMS2 9705497 ENSP00000352224 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows functional complementation of a yeast mms2 mutant by human hMMS2 (ENSP00000352224). A second hMMS2 peptide (ENSP00000326473) in the same OrthoMCL family and is also a product of ENSG00000169139 but was not the sequence used in the experiment. YGL087C MMS2 9705497 ENSP00000354653 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that a truncated form of ENSP00000354653 (CROC-1B 81-221) complements a yeast mms2 mutant, but full-length CROC-1B does not. There are several other peptides associated with ENSG00000124208, including two (ENSP00000340305 and ENSP00000344166) in the same OrthoMCL family." YPL228W CET1 9710603 ENSMUSP00000029942 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YOR176W HEM15 9753778 AT5G26030.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR176W HEM15 9753778 AT2G30390.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YPL228W CET1 9755857 CaCET1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YPL228W CET1 9755857 ENSP00000339517 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that the 597aa Hce1p complements a yeast cet1 mutant, but that the shorter peptides Hce1ap and Hce1bp do not." YPL228W CET1 9755857 ENSP00000265607 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "ENSP00000265607 is the 574aa Hce1ap described in this paper. A shorter peptide, Hce1b, also fails to complement a yeast cet1 mutant but is not currently listed in Ensembl." YHR030C SLT2 9770551 Mps1 MAGNAPORTHE_GRISEA SACCHAROMYCES_CEREVISIAE yes YLL026W HSP104 9784498 HSP101 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes YLL026W HSP104 9784498 HSP101 NICOTIANA_TABACUM SACCHAROMYCES_CEREVISIAE yes YBR058C UBP14 9786928 UbpA DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes This paper shows complementation in both directions. YBR058C UBP14 9786928 UBP14 SACCHAROMYCES_CEREVISIAE DICTYOSTELIUM_DISCOIDEUM yes This paper shows complementation in both directions. UbpA YEL022W GEA2 9790530 GEA2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes the production of the Gea2p Sec7 domain in E. coli for structural studies. NONE YEL046C GLY1 9797278 GLY1 ASHBYA_GOSSYPII SACCHAROMYCES_CEREVISIAE yes YBR160W CDC28 9803415 CRK2 PLASMODIUM_KNOWLESI SACCHAROMYCES_CEREVISIAE no YBR160W CDC28 9803415 CRK2 PLASMODIUM_BERGHEI SACCHAROMYCES_CEREVISIAE no YLR216C CPR6 9819421 ENSP00000303754 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human cyclophilin 40 fails to complement either a yeast cpr7 mutant or a cpr6 cpr7 double mutant. YJR032W CPR7 9819421 ENSP00000303754 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no Human cyclophilin 40 fails to complement either a yeast cpr7 mutant or a cpr6 cpr7 double mutant. YKL113C RAD27 9823303 ENSP00000284576|ENSP00000311873 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that a truncated 803aa peptide of hEXO1, like yeast Exo1p, is capable of suppressing the mutator phenotype of rad27 yeast. The Ensembl peptides listed here each have 846 aa." YJL140W RPB4 9829926 RPB4 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YKL113C RAD27 9830061 UNKNOWN:FEN-1 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes FEN-1 may be ENSP00000305480. YBL106C SRO77 9837945 CG2671-PA|CG2671-PB|CG2671-PC|CG2671-PD|CG2671-PE|CG2671-PF DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes This paper shows that Drosophila l(2)gl partially complements a yeast sro7 sro77 double mutant. YPR032W SRO7 9837945 CG2671-PA|CG2671-PB|CG2671-PC|CG2671-PD|CG2671-PE|CG2671-PF DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes This paper shows that Drosophila l(2)gl partially complements a yeast sro7 sro77 double mutant. YKL113C RAD27 9852084 FEN-1 XENOPUS_LAEVIS SACCHAROMYCES_CEREVISIAE yes YNL259C ATX1 9862443 ZK652.11 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes YDR045C RPC11 9869639 C11 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes This paper shows complementation by S. pombe C11 and mentions non-complementation by human C11. YDR045C RPC11 9869639 ENSP00000293860 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no This paper shows complementation by S. pombe C11 and mentions non-complementation by human C11. YHL003C LAG1 9872981 ENSP00000247005 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human LAG1 complements a yeast lag1 lac1 mutant. YKL008C LAC1 9872981 ENSP00000247005 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that human LAG1 complements a yeast lag1 lac1 mutant. YHL003C LAG1 9872981 C09G4.1 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes This paper shows that C. elegans LAG1 complements a yeast lag1 lac1 mutant. YKL008C LAC1 9872981 C09G4.1 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE yes This paper shows that C. elegans LAG1 complements a yeast lag1 lac1 mutant. YHL003C LAG1 9872981 ENSP00000262213 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no This paper shows that human TRAM does not complement a yeast lag1 lac1 mutant. YKL008C LAC1 9872981 ENSP00000262213 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no This paper shows that human TRAM does not complement a yeast lag1 lac1 mutant. YMR079W SEC14 9874205 AT4G39180.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOL090W MSH2 9889267 ENSP00000233146 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "Introduction of human MSH2 (ENSP00000233146), MSH3 (ENSP00000265081) or MSH6 (ENSP00000234420), either alone or in combination, does not decrease the high reversion rate of a yeast msh2 mutant." YOL090W MSH2 9889267 ENSP00000265081 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "Introduction of human MSH2 (ENSP00000233146), MSH3 (ENSP00000265081) or MSH6 (ENSP00000234420), either alone or in combination, does not decrease the high reversion rate of a yeast msh2 mutant." YOL090W MSH2 9889267 ENSP00000234420 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "Introduction of human MSH2 (ENSP00000233146), MSH3 (ENSP00000265081) or MSH6 (ENSP00000234420), either alone or in combination, does not decrease the high reversion rate of a yeast msh2 mutant." YJR069C HAM1 9918490 HAM1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt This paper describes functional expression of Ham1p in E. coli. NONE YDR363W-A SEM1 9927667 ENSMUSP00000040741 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes DSS1 is a synonym of Shfm1. YOR224C RPB8 9927738 rpb8 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE no YMR224C MRE11 9931460 ENSP00000325863|ENSP00000326094 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt "This paper deals with MRE11B, which is now known to be a pseudogene of MRE11A." YGL008C PMA1 9952459 PMA4 NICOTIANA_PLUMBAGINIFOLIA SACCHAROMYCES_CEREVISIAE yes This paper shows that NICOTIANA_PLUMBAGINIFOLIA PMA4 restores function to a yeast pma1 pma2 strain. YPL036W PMA2 9952459 PMA4 NICOTIANA_PLUMBAGINIFOLIA SACCHAROMYCES_CEREVISIAE yes This paper shows that NICOTIANA_PLUMBAGINIFOLIA PMA4 restores function to a yeast pma1 pma2 strain. YGR202C PCT1 9990094 LjNPP2C1 LOTUS_JAPONICUS SACCHAROMYCES_CEREVISIAE yes YBL019W APN2 10022867 APN2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes Yeast YBL019W/APN2/ETH1 complements an E.coli dut-1 xthA3 double mutant; yeast APN2 is identified as a homolog of E. coli exonuclease III. YGL006W PMC1 10027971 SERCA1a ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that the rabbit SERCA1a Ca(2+)-ATPase complements yeast pmr1 pmc1 cnb1 and pmr1 pmc1 vcx1 triple mutants. YGL167C PMR1 10027971 SERCA1a ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that the rabbit SERCA1a Ca(2+)-ATPase complements yeast pmr1 pmc1 cnb1 and pmr1 pmc1 vcx1 triple mutants. YGR267C FOL2 10049741 ENSP00000352686|ENSP00000254299 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YGR267C FOL2 10049741 FOLE ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YHR008C SOD2 10066423 FeSOD ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YJL129C TRK1 10066736 HKT1 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE no expt YKR050W TRK2 10066736 HKT1 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE no expt YER026C CHO1 10066765 TaPSS1 TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE yes YMR190C SGS1 10069810 ENSP00000347232|ENSP00000349859 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same human gene, ENSG00000197299. Human BLM partially complements the phenotypes assoicated with sgs1 mutations in a yeast sgs1 top3 double mutant." YDR490C PKH1 10074427 ENSP00000344220|ENSP00000346895 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A yeast pkh1 pkh2 double mutant was used because the two are functionally redundant. YKL126W YPK1 10074427 ENSP00000305509|ENSP00000340608 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant. YMR104C YPK2 10074427 ENSP00000305509|ENSP00000340608 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A yeast ypk1 ypk2 double mutant was used because the two are functionally redundant. YOL100W PKH2 10074427 ENSP00000344220|ENSP00000346895 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A yeast pkh1 pkh2 double mutant was used because the two are functionally redundant. YLR237W THI7 10074490 THI7 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS yes "This paper shows that the yeast thiamine transporter THI10 (alias for THI7) rescues thiamine-responsive megaloblastic anemia (TRMA) fibroblasts indicating an apparent deficiency of a thiamine transporter in the TRMA cells. Although this paper did not identify the human thiamine transporter, two separate publications (PubMed ids: 10391221, 10391223) identified mutations in the human SLC19A2 gene (ENSP00000236137) encoding a thiamine transporter that were found to cause thiamine-responsive megaloblastic anaemia syndrome." ENSP00000236137 YFL014W HSP12 10080714 Em TRITICUM_AESTIVUM SACCHAROMYCES_CEREVISIAE no expt "This paper shows functional expression of the wheat Group 1 late embryogenesis-abundant (LEA) protein, Em, in yeast, but not complementation." YPR016C TIF6 10085284 ENSP00000246231 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YAL035W FUN12 10200264 ENSP00000289371 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human eukaryotic translation initiation factor 5B (eIF-5B) (ENSP00000289371) is also known as Translation initiation factor IF-2. YJR153W PGU1 10206190 EPG1 KLUYVEROMYCES_MARXIANUS SACCHAROMYCES_CEREVISIAE no expt "This paper shows functional expression of Kluyveromyces marxianus EPG1 in Saccharomyces cerevisiae, but not complementation." YJR053W BFA1 10209303 BFA1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no Saccharomyces cerevisiae BFA1 is also known as IBD1. YEL009C GCN4 10220324 GCN4 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YMR216C SKY1 10225947 UNKNOWN:SRPK1 UNKNOWN:MAMMALIAN SACCHAROMYCES_CEREVISIAE yes YOR122C PFY1 10231360 ENSP00000225655 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "In this paper, human PFN1 (Ensembl peptide id: ENSP00000225655) was used to complement yeast pfy1." YGR142W BTN2 10319861 ENSP00000353116 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt ENSP00000353116 is one of the peptides encoded by the human CLN3 gene (ENSG00000188603). YBR289W SNF5 10325430 AT3G17590.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana AT3G17590.1 (BSH) partially complements the yeast snf5 mutant. YGR121C MEP1 10330477 AT1G64780.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "A. thaliana AT1G64780.1 is an ammonium transporter 1, member 2 (AMT1.2) that is nearly identical to AMT2 (AT2G38290.1, AT2G38290.2) which is in the OrthoMCL family with yeast MEP1. " YOR204W DED1 10336476 ENSP00000310870 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human ENSP00000310870 corresponds to the Genbank accession number AF000982 noted in the paper. YGL173C KEM1 10349620 CG3291-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YGL008C PMA1 10353834 AT4G30190.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper shows that wild-type AHA2 does not complement a pma1 mutant, but mutants of AHA2 lacking the C-terminal domain or with key residues mutated do complement." YML120C NDI1 10354494 NDI1 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS no expt This paper describes the functional expression of NDI1 in human 293 cells. NONE YOL004W SIN3 10357820 ENSMUSP00000004494 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no expt This paper shows that the mSin3B mouse homolog of yeast SIN3 (ENSMUSP00000004494) interacts with mouse Ikaros (ENSMUSP00000018798) in a yeast two-hybrid assay. YGL073W HSF1 10358080 ENSP00000332698 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Although human HSF1 is an inactive monomer in yeast that is unable to substitute for the essential yeast HSF protein, mutations in the linker region between the DNA binding domain and the first coiled-coil allow human HSF1 to homotrimerize and rescue the viability defect of a hsf yeast strain." YPL252C YAH1 10375636 ENSP00000260270 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YEL021W URA3 10380627 URA3 SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_EXIGUUS no expt YLR109W AHP1 10391912 AHP1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YJL080C SCP160 10393197 CG5170-PA|CG5170-PB|CG5170-PC|CG5170-PD|CG5170-PE|CG5170-PF DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YMR197C VTI1 10397763 AT5G39510.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes This paper shows that A. thaliana VTI11 (also known as VTI11a) complements a yeast vti1 null mutant. YMR197C VTI1 10397763 AT1G26670.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes This paper shows that A. thaliana VTI11 (also known as VTI11b) complements a yeast vti1 null mutant. YHR007C ERG11 10398344 ENSP00000003100 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt YIL144W TID3 10409732 ENSP00000261597 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YNL088W TOP2 10416608 ENSP00000342944 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDR394W RPT3 10417703 AT5G58290.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGL048C RPT6 10417703 AT5G19990.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "AT5G19990.1 is the Arabidopsis RPT6a subunit, whereas AT5G20000.1 is almost identical to the RPT6a subunit." YKL145W RPT1 10417703 AT1G53750.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "AT1G53750.1 is the Arabidopsis RPT1a subunit, whereas AT1G53780.1 is similar to the RPT1a subunit. " YOR117W RPT5 10417703 AT3G05530.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "AT3G05530.1 is the Arabidopsis RPT5a subunit, whereas AT1G09100.1 is similar to the RPT5a subunit." YOR259C RPT4 10417703 AT5G43010.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YPR060C ARO7 10428795 aroC ASPERGILLUS_NIDULANS SACCHAROMYCES_CEREVISIAE yes YBR201W DER1 10430031 UNKNOWN:murine mu MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no expt "This paper shows heterologous expression of murine mu in yeast, not complementation." YER100W UBC6 10430031 UNKNOWN:murine mu MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no expt "This paper shows heterologous expression of murine mu in yeast, not complementation." YJL034W KAR2 10430031 UNKNOWN:murine mu MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no expt "This paper shows heterologous expression of murine mu in yeast, not complementation." YMR022W QRI8 10430031 UNKNOWN:murine mu MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no expt "This paper shows heterologous expression of murine mu in yeast, not complementation." YOR057W SGT1 10445024 ENSP00000298172 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR117C CLF1 10445879 CG3193-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YEL027W CUP5 10464277 16 kDa proteolipid NEPHROPS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YGR289C MAL11 10481063 AJ132781 THERMOCOCCUS_HYDROTHERMALIS SACCHAROMYCES_CEREVISIAE yes AJ132781 is the EMBL Nucleotide Database accession number for the T. hydrothermal protein. YBR218C PYC2 10481094 Phosphoenolpyruvate carboxylase ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YGL062W PYC1 10481094 Phosphoenolpyruvate carboxylase ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YDR529C QCR7 10491129 ENSP00000287022 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no The human protein referred to as Hum7 in this paper corresponds to Emsembl peptide ENSP00000287022. Hum7 was found not to functionally complement the yeast qcr7 mutant (see table 1 of paper). YDR529C QCR7 10491129 POT7 SOLANUM_TUBEROSUM SACCHAROMYCES_CEREVISIAE no YJL166W QCR8 10491129 BOV8 BOS_TAURUS SACCHAROMYCES_CEREVISIAE no YJL166W QCR8 10491129 POT8 SOLANUM_TUBEROSUM SACCHAROMYCES_CEREVISIAE no YJL166W QCR8 10491129 Nc8-1 NEUROSPORA_CRASSA SACCHAROMYCES_CEREVISIAE yes YDL164C CDC9 10497258 EcoLIG ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes E. coli EcoLIG complements a yeast cdc9 mutant. YDL164C CDC9 10497258 ChVLIG CHLORELLA_VIRUS SACCHAROMYCES_CEREVISIAE yes ChVLIG complements a yeast cdc9 mutant. YOR005C DNL4 10497258 EcoLIG ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no expt E. coli EcoLIG rescues a yeast cdc9 dnl4 double mutant. The yeast double mutant was tested in case Dnl4p was compensating for EcoLIG in the yeast cdc9 complementation assay. YOR005C DNL4 10497258 ChVLIG CHLORELLA_VIRUS SACCHAROMYCES_CEREVISIAE no expt ChVLIG rescues a yeast cdc9 dnl4 double mutant. The yeast double mutant was tested in case Dnl4p was compensating for ChVLIG in the yeast cdc9 complementation assay. YML086C ALO1 10508108 ALO1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt "This paper shows functional expression of Alo1p in E. coli, but not complementation." NONE YOR107W RGS2 10523302 ENSMUSP00000027606 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no YOR107W RGS2 10523302 ENSMUSP00000083137 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YOR107W RGS2 10523302 ENSMUSP00000027748 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YOR107W RGS2 10523302 ENSP00000204113 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YOR107W RGS2 10523302 ENSP00000235382 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YOR107W RGS2 10523302 ENSP00000322496 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "A truncated form of RGS3, RGS3T, also fails to complement." YOR107W RGS2 10523302 Rgs4 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YGR252W GCN5 10536141 TgGCN5 TOXOPLASMA_GONDII SACCHAROMYCES_CEREVISIAE no YHR007C ERG11 10537193 CaERG11 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE no expt YKL113C RAD27 10545607 ENSP00000305480 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDL141W BPL1 10551847 BPL1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no YDR331W GPI8 10564469 ENSP00000271047|ENSP00000352041|ENSP00000359846|ENSP00000359848|ENSP00000359849 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJR010W MET3 10564518 MET3 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YPL031C PHO85 10567344 ENSMUSP00000018813 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Mouse ENSMUSP00000018813 (Cdk5) partially complements a yeast pho85 null mutant. YFR019W FAB1 10567352 ENSMUSP00000079926 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YFR019W FAB1 10567352 FAB1 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes This paper shows partial complementation of a yeast fab1 null mutant by S. pombe FAB1. YOR143C THI80 10567383 ENSMUSP00000065631|ENSMUSP00000087596 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same mouse gene, ENSMUSG00000029735." YDR490C PKH1 10567559 ENSP00000344220|ENSP00000346895 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A yeast pkh1 pkh2 double mutant was used because the two are functionally redundant. YOL100W PKH2 10567559 ENSP00000344220|ENSP00000346895 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A yeast pkh1 pkh2 double mutant was used because the two are functionally redundant. YDR069C DOA4 10570463 DOA4 SACCHAROMYCES_CEREVISIAE DROSOPHILA_MELANOGASTER no CG1945-PA|CG1945-PC YER151C UBP3 10570463 UBP3 SACCHAROMYCES_CEREVISIAE DROSOPHILA_MELANOGASTER yes CG1945-PA|CG1945-PC YOR124C UBP2 10570463 UBP2 SACCHAROMYCES_CEREVISIAE DROSOPHILA_MELANOGASTER yes CG1945-PA|CG1945-PC YLR200W YKE2 10581246 MtGim-beta METHANOBACTERIUM_THERMOAUTOTROPHICUM SACCHAROMYCES_CEREVISIAE yes M. thermoautotrophicum MtGim-beta partially complements a yeast yke2 mutant. YML094W GIM5 10581246 MtGim-alpha METHANOBACTERIUM_THERMOAUTOTROPHICUM SACCHAROMYCES_CEREVISIAE no YEL003W GIM4 10581246 MtGim-beta METHANOBACTERIUM_THERMOAUTOTROPHICUM SACCHAROMYCES_CEREVISIAE yes M. thermoautotrophicum MtGim-beta partially complements a yeast gim4 mutant. YKL117W SBA1 10581266 SBA1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes This paper shows that S. cerevisiae SBA1 is a functional homolog of S. pombe Wos2 (GenBank id: YSPWOS2). YML077W BET5 10582700 ENSP00000302783 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YER136W GDI1 10592042 OsGDI1 ORYZA_SATIVA SACCHAROMYCES_CEREVISIAE yes YER136W GDI1 10592042 OsGDI2 ORYZA_SATIVA SACCHAROMYCES_CEREVISIAE yes YGL125W MET13 10593891 MTHFR ZEA_MAYS SACCHAROMYCES_CEREVISIAE yes Maize MTHFR complements a yeast met12 met13 double mutant. YGL125W MET13 10593891 AT3G59970.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana MTHFR-1 complements a yeast met12 met13 double mutant. YGL125W MET13 10593891 AT2G44160.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana MTHFR-1 complements a yeast met12 met13 double mutant. YPL023C MET12 10593891 MTHFR ZEA_MAYS SACCHAROMYCES_CEREVISIAE yes Maize MTHFR complements a yeast met12 met13 double mutant. YPL023C MET12 10593891 AT3G59970.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana MTHFR-1 complements a yeast met12 met13 double mutant. YPL023C MET12 10593891 AT2G44160.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana MTHFR-1 complements a yeast met12 met13 double mutant. YGL125W MET13 10600168 ENSP00000315965 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human MTHFR complements a yeast met13 mutant and a met12 met13 double mutant. YGL125W MET13 10600168 UNKNOWN:MTHFR ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis MTHFR complements a yeast met13 mutant and a met12 met13 double mutant. YGL125W MET13 10600168 MetF ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no E. coli MetF complements neither a yeast met13 mutant nor a met12 met13 double mutant. YPL023C MET12 10600168 ENSP00000315965 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human MTHFR complements a yeast met13 mutant and a met12 met13 double mutant. YPL023C MET12 10600168 UNKNOWN:MTHFR ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes Arabidopsis MTHFR complements a yeast met13 mutant and a met12 met13 double mutant. YPL023C MET12 10600168 MetF ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE no E. coli MetF complements neither a yeast met13 mutant nor a met12 met13 double mutant. YJR104C SOD1 10601249 ENSP00000307870 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes A D200H mutant of human CCS complements a yeast sod1 mutant. YJR104C SOD1 10601249 UNKNOWN:SOD1 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "Wild-type human SOD1, but not an H120D mutant, complements a yeast sod1 mutant." YDR192C NUP42 10610322 ENSP00000258742 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "The authors tested human ENSP00000258742 (NUPL2, hCG1) and found that it did not complement a yeast nup42 mutant which they refer to as a yeast rip1 mutant due to a nomenclature conflict." YLR113W HOG1 10620778 HOG1 DEBARYOMYCES_HANSENII SACCHAROMYCES_CEREVISIAE yes The D. Hansenii HOG1 Genbank accession identifier is AF185278. YHR164C DNA2 10636853 XDna2 XENOPUS_LAEVIS SACCHAROMYCES_CEREVISIAE yes YLR340W RPP0 10636918 RPP0 ASPERGILLUS_FUMIGATUS SACCHAROMYCES_CEREVISIAE yes This paper shows complementation of a conditional yeast RPP0 null phenotype that is viable only when grown in galactose as a carbon source. The heterologous RPP0 protein was considered tofunctionally substitute for the essential yeast Rpp0 protein if the transformed strain could grow in glucose media. YLR340W RPP0 10636918 RPP0 DICTYOSTELIUM_DISCOIDEUM SACCHAROMYCES_CEREVISIAE yes This paper shows complementation of a conditional yeast RPP0 null phenotype that is viable only when grown in galactose as a carbon source. The heterologous RPP0 protein was considered tofunctionally substitute for the essential yeast Rpp0 protein if the transformed strain could grow in glucose media. YLR340W RPP0 10636918 RPP0 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes This paper shows complementation of a conditional yeast RPP0 null phenotype that is viable only when grown in galactose as a carbon source. The heterologous RPP0 protein was considered tofunctionally substitute for the essential yeast Rpp0 protein if the transformed strain could grow in glucose media. YLR340W RPP0 10636918 RPP0 LEISHMANIA_INFANTUM SACCHAROMYCES_CEREVISIAE no This paper shows complementation of a conditional yeast RPP0 null phenotype that is viable only when grown in galactose as a carbon source. The heterologous RPP0 protein was considered tofunctionally substitute for the essential yeast Rpp0 protein if the transformed strain could grow in glucose media. YNL088W TOP2 10636919 ENSP00000342944 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR340W RPP0 10637325 CcP0 CERATITIS_CAPITATA SACCHAROMYCES_CEREVISIAE no expt This paper describes an in vivo functional analysis that involved expressing the ribosomal P-protein genes of the medfly C.capitata in S.cerevisiae rpp0 conditional null mutants. YLR340W RPP0 10637325 CcP1 CERATITIS_CAPITATA SACCHAROMYCES_CEREVISIAE no expt This paper describes an in vivo functional analysis that involved expressing the ribosomal P-protein genes of the medfly C.capitata in S.cerevisiae rpp0 conditional null mutants. YLR340W RPP0 10637325 CcP2 CERATITIS_CAPITATA SACCHAROMYCES_CEREVISIAE no expt This paper describes an in vivo functional analysis that involved expressing the ribosomal P-protein genes of the medfly C.capitata in S.cerevisiae rpp0 conditional null mutants. YKL049C CSE4 10639145 CSE4 SACCHAROMYCES_CEREVISIAE DROSOPHILA_MELANOGASTER no expt NONE YBR143C SUP45 10648963 Tt-eRF1 TETRAHYMENA_THERMOPHILA SACCHAROMYCES_CEREVISIAE no YBR143C SUP45 10648963 Ra-eRF1 ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes YLR029C RPL15A 10673398 rpl10a CHLAMYDOMONAS_REINHARDTII SACCHAROMYCES_CEREVISIAE no expt "This paper shows that C. reihnardtii rpl10a is able to suppress a yeast yap1 null mutant, but it shows greater homology to yeast RPL15A (alias RPL10A)." YDR397C NCB2 10675336 ENSP00000236164|ENSP00000359290|ENSP00000359295 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YER159C BUR6 10675336 ENSP00000307850|ENSP00000366190 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJL101C GSH1 10675565 CG2259-PA|CG2259-PB DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes "Both peptides map to the same D. melanogaster gene, Gclc. This paper shows that D. melanogaster Gclc partially complements a yeast gsh1 null mutant." YBL075C SSA3 10677504 UNKNOWN:Ht HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper describes the characterization of variant truncated forms of the human Huntington's disease protein expressed in yeast. YLL026W HSP104 10677504 UNKNOWN:Ht HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper describes the characterization of variant truncated forms of the human Huntington's disease protein expressed in yeast. YNL007C SIS1 10677504 UNKNOWN:Ht HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper describes the characterization of variant truncated forms of the human Huntington's disease protein expressed in yeast. YJR117W STE24 10692417 ENSP00000196805 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOL086C ADH1 10732677 alcohol dehydrogenase CERATITIS_CAPITATA SACCHAROMYCES_CEREVISIAE yes "This paper describes the cloning of a C. capitata alcohol dehydrogenase gene by functional complementation of a yeast adh1 null mutant, however the cloned gene is unrelated in sequence to yeast ADH1." YOL086C ADH1 10732677 alcohol dehydrogenase BACTROCERA_OLEAE SACCHAROMYCES_CEREVISIAE yes YOR150W MRPL23 10743564 KlMRP-L23 KLUYVEROMYCES_LACTIS SACCHAROMYCES_CEREVISIAE yes YGR121C MEP1 10743657 LeAMT1;1|LeAMT1;2|LeAMT1;3 LYCOPERSICON_ESCULENTUM SACCHAROMYCES_CEREVISIAE yes YLR304C ACO1 10748225 IRP1 ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes YDR135C YCF1 10753671 YCF1 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt The authors expressed yeast YCF1 in Sf21 insect cells and found that the localization of the protein was different from that in yeast. YMR062C ECM40 10753950 ECM40 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt "This paper shows functional expression of yeast ECM40 in E. coli, but not complementation." YOR241W MET7 10775416 folC LACTOBACILLUS_CASEI SACCHAROMYCES_CEREVISIAE yes YIL144W TID3 10779342 ENSP00000261597 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YER031C YPT31 10791890 PRA2 PISUM_SATIVUM SACCHAROMYCES_CEREVISIAE no YER136W GDI1 10791890 PRA2 PISUM_SATIVUM SACCHAROMYCES_CEREVISIAE no YFL005W SEC4 10791890 PRA2 PISUM_SATIVUM SACCHAROMYCES_CEREVISIAE no YFL038C YPT1 10791890 PRA2 PISUM_SATIVUM SACCHAROMYCES_CEREVISIAE no YGL210W YPT32 10791890 PRA2 PISUM_SATIVUM SACCHAROMYCES_CEREVISIAE no YDR302W GPI11 10793139 ENSP00000281382 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YBR018C GAL7 10799308 ENSP00000338703 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes This paper shows that overexpression of human UGP2 (ENSP00000338703) rescues a yeast gal7 null mutant. YPR200C ARR2 10801893 ARR2 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes YPR005C HAL1 10806256 HAL1 SACCHAROMYCES_CEREVISIAE LYCOPERSICON_ESCULENTUM no expt This paper shows that the heterologous expression of yeast HAL1 in tomato plants improves their salt tolerance. YPR113W PIS1 10809447 AT1G68000.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YFL016C MDJ1 10821188 DnaJ ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes YDR276C PMP3 10835350 AT3G05880.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YBL078C ATG8 10837468 ATG8 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt Recombinant yeast Atg8p was produced in E. coli and used in an assay to demonstrate that it is a functional homologue of mammalian GATE-16. YJR104C SOD1 10882731 ENSP00000270142 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YKL212W SAC1 10887188 Sac1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YBR133C HSL7 10903903 ENSP00000319169 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLL026W HSP104 10920207 UNKNOWN:huntingtin HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper describes the characterization of the human Huntington's disease protein expressed in yeast. YGL115W SNF4 10929106 AT1G09020.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGR195W SKI6 10930416 AT3G61620.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YDR270W CCC2 10942420 ENSP00000242839|ENSP00000342559 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt Both peptides map to the same human ATP7B gene (ENSG00000123191). This paper shows the localization of human variant ATP7B proteins in yeast. YGL142C GPI10 10954751 TbGPI10 TRYPANOSOMA_BRUCEI SACCHAROMYCES_CEREVISIAE yes YGL142C GPI10 10954751 ENSP00000164305 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPR124W CTR1 10974539 ENSMUSP00000081574 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes mCTR1 complemented a yeast ctr1 ctr3 double deletion. YPR124W CTR1 10974539 ENSP00000259393|ENSP00000363329 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes hCTR1 complemented a yeast ctr1 ctr3 double deletion. YKL149C DBR1 10982890 ENSP00000260803|ENSP00000349649 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOL012C HTZ1 11000274 tHTZ1 TETRAHYMENA_THERMOPHILA SACCHAROMYCES_CEREVISIAE yes YIL051C MMF1 11003673 ENSP00000254878 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YMR038C CCS1 11027581 ENSP00000307870 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YPR183W DPM1 11030744 dpm1 TRICHODERMA_REESEI SACCHAROMYCES_CEREVISIAE no "Trdpm1 complements S. pombe dpm1+, but neither gene complements S. cerevisiae dpm1." YDL120W YFH1 11030757 ENSP00000297735 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR284C ECI1 11032827 MFE TYPE 1 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt YLR284C ECI1 11032827 ECI RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE no expt YML004C GLO1 11050082 GLO1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YLR242C ARV1 11063737 ENSP00000312458 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YDL208W NHP2 11074001 ENSP00000274606 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YHR072W-A NOP10 11074001 ENSP00000332198 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR382C NAM2 11087829 ENSP00000265537 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR382C NAM2 11087829 LeuRS MYCOBACTERIUM_TUBERCULOSIS SACCHAROMYCES_CEREVISIAE yes YOR048C RAT1 11106401 AT5G42540.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR048C RAT1 11106401 AT1G75660.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR048C RAT1 11106401 AT1G54490.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR274W MOD5 11111046 ENSP00000046894|ENSP00000321810 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOR334W MRS2 11115130 AT1G16010.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR334W MRS2 11115130 AT5G64560.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no YDR074W TPS2 11115409 treA BACILLUS_SUBTILIS SACCHAROMYCES_CEREVISIAE yes B. subtilis treA phosphotrehalase corresponds to the SwissProt accession id P39795. YGL006W PMC1 11115896 AT2G41560.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper shows that AT2G41560.1 (ACA4) functions as a Ca2+ Pump, but only an N-terminally modified form of ACA4 rescues a yeast pmr1 pmc1 cnb1 triple mutant. The truncation of the N-terminal region seems to transfer ACA4 into an activated state." YGL167C PMR1 11115896 AT2G41560.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper shows that AT2G41560.1 (ACA4) functions as a Ca2+ Pump, but only an N-terminally modified form of ACA4 rescues a yeast pmr1 pmc1 cnb1 triple mutant. The truncation of the N-terminal region seems to transfer ACA4 into an activated state." YPR062W FCY1 11118048 FCY1 SACCHAROMYCES_CEREVISIAE HOMO_SAPIENS no expt The authors generated stable HT29 human colon cancer cell lines expressing yeast FCY1 (yCD) and found that FCY1 cytosine deaminase improves the radiosensitization and bystander effect by 5-fluorocytosine. YBR037C SCO1 11118289 SCO1/ENSP00000255390 SACCHAROMYCES_CEREVISIAE/HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes The authors used chimeric proteins with the amino-terminal portion from yeast Sco1p and carboxy-terminal portion from the human ENSP00000255390 (hSco1p). These chimeras are able to complement yeast sco1 null mutants. YJR017C ESS1 11118437 DlPar13 DIGITALIS_LANATA SACCHAROMYCES_CEREVISIAE yes YJR017C ESS1 11118437 ENSP00000247970 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJR017C ESS1 11118437 ENSP00000218432 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no "Human Par14/Pin4 (ENSP00000218432) was shown not to complement a yeast ess1 mutant, whereas human Pin1 (ENSP00000247970) did complement the yeast ess1 mutant indicating that it is likely the functional homolog of yeast Ess1p." YJR017C ESS1 11118438 MdPin1 MALUS_DOMESTICA SACCHAROMYCES_CEREVISIAE yes MdPin1 has the GenBank accession id AF209200. YJR017C ESS1 11118438 AT2G18040.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YHR002W LEU5 11158296 ENSP00000265870 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YHR002W LEU5 11158296 ENSP00000265870 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOR100C CRC1 11162577 ENSP00000326305 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "This paper shows that human CACT (ENSP00000326305) complements a yeast crc1 cit2 double mutant, but the authors state that human CACT is the functional ortholog of yeast Crc1p, not Cit2p." YGL253W HXK2 11164592 LeHXK2 LYCOPERSICON_ESCULENTUM SACCHAROMYCES_CEREVISIAE yes This paper shows that L. esculentum LEHXK2 complements a yeast hxk1 hxk2 glk1 triple mutant which lacks the ability to phosphorylate glucose and fructose. YFR053C HXK1 11164592 LeHXK2 LYCOPERSICON_ESCULENTUM SACCHAROMYCES_CEREVISIAE yes This paper shows that L. esculentum LEHXK2 complements a yeast hxk1 hxk2 glk1 triple mutant which lacks the ability to phosphorylate glucose and fructose. YCL040W GLK1 11164592 LeHXK2 LYCOPERSICON_ESCULENTUM SACCHAROMYCES_CEREVISIAE yes This paper shows that L. esculentum LEHXK2 complements a yeast hxk1 hxk2 glk1 triple mutant which lacks the ability to phosphorylate glucose and fructose. YCR048W ARE1 11171173 H19N07.4 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE no expt This paper describes the heterologous expression of several DGAT's in wild-type yeast. YNR019W ARE2 11171173 H19N07.4 CAENORHABDITIS_ELEGANS SACCHAROMYCES_CEREVISIAE no expt This paper describes the heterologous expression of several DGAT's in wild-type yeast. YCR048W ARE1 11171173 AT2G19450.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper describes the heterologous expression of several DGAT's in wild-type yeast. YNR019W ARE2 11171173 AT2G19450.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt This paper describes the heterologous expression of several DGAT's in wild-type yeast. YCR048W ARE1 11171173 NtDGAT NICOTIANA_TABACUM SACCHAROMYCES_CEREVISIAE no expt This paper describes the heterologous expression of several DGAT's in wild-type yeast. YNR019W ARE2 11171173 NtDGAT NICOTIANA_TABACUM SACCHAROMYCES_CEREVISIAE no expt This paper describes the heterologous expression of several DGAT's in wild-type yeast. YER177W BMH1 11182236 14-3-3 protein TOXOPLASMA_GONDII SACCHAROMYCES_CEREVISIAE yes YDR023W SES1 11223940 CaSES1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YDL108W KIN28 11226158 KIN28 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE no expt KIN28 was used for a suppression experiment in S. pombe. NONE YFL029C CAK1 11226158 csk1 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YFL029C CAK1 11226158 CAK1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes csk1 YFL029C CAK1 11226158 mcs2 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes Both mcs2 and mcs6 are required for complementation. YFL029C CAK1 11226158 mcs6 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes Both mcs2 and mcs6 are required for complementation. YAL016W TPD3 11247601 RPA1 ORYZA_SATIVA SACCHAROMYCES_CEREVISIAE yes YDR477W SNF1 11252725 AT3G29160.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt "This paper shows functional expression of A. thaliana AT3G29160.1 (AKIN11) in yeast, but not complementation." YGL115W SNF4 11252725 AT1G09020.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGL115W SNF4 11252725 ZmAKINbeta ZEA_MAYS SACCHAROMYCES_CEREVISIAE yes YJR074W MOG1 11290418 ENSP00000226105 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YIL002C INP51 11311145 ENSMUSP00000071671 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Mouse Inpp5b complements a yeast inp51 inp52 double mutant and inp51 inp52 inp53 triple mutant. YNL106C INP52 11311145 ENSMUSP00000071671 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Mouse Inpp5b complements a yeast inp51 inp52 double mutant and inp51 inp52 inp53 triple mutant. YOR109W INP53 11311145 ENSMUSP00000071671 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Mouse Inpp5b complements a yeast inp51 inp52 double mutant and inp51 inp52 inp53 triple mutant. YJR040W GEF1 11326746 ENSMUSP00000030879 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes YJR040W GEF1 11326746 ENSMUSP00000035964 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE no YBR126C TPS1 11329880 TPS1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI yes This article is in Chinese. otsA YDR410C STE14 11352465 AT5G23320.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana AT5G23320.1 corresponds to the MKD15 clone referred to in the GenBank entry AB007648 listed in this paper. YKL149C DBR1 11355701 ENSMUSP00000070991 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes This paper shows that mouse mDBR1 (ENSMUSP00000070991) complements an S. cerevisiae dbr1 null mutant to the wild type level when mDBR1 is expressed using a high copy plasmid. YGL006W PMC1 11382780 TcSCA TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE yes "This paper shows that T. cruzi TcSCA contains several sequence motifs found in Ca2+-ATPases and that it complements a yeast triple mutant (pmr1 pmc1 cnb 1) deficient in the Ca(2+) pumps, indicating that TsSCA encodes a functional Ca2+-ATPase. " YGL167C PMR1 11382780 TcSCA TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE yes "This paper shows that T. cruzi TcSCA contains several sequence motifs found in Ca2+-ATPases and that it complements a yeast triple mutant (pmr1 pmc1 cnb 1) deficient in the Ca(2+) pumps, indicating that TsSCA encodes a functional Ca2+-ATPase." YFR028C CDC14 11427967 CaCDC14 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YIL004C BET1 11445081 AT4G14455.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no YIL004C BET1 11445081 AT3G58170.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no YKL006C-A SFT1 11445081 AT4G14455.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YKL006C-A SFT1 11445081 AT3G58170.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YER026C CHO1 11461929 SDC BRASSICA_NAPUS SACCHAROMYCES_CEREVISIAE yes YGR170W PSD2 11461929 AT1G43710.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YNL169C PSD1 11461929 AT1G43710.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGL130W CEG1 11463793 PCE1 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YPL228W CET1 11463793 ENSMUSP00000029942 MUS_MUSCULUS SACCHAROMYCES_CEREVISIAE yes Figure 3 of this paper shows that a recombinant protein consisting of a truncated form of ENSMUSP00000029942 (MCE1 1-210) fused to yeast Ceg1p can partially complement a yeast cet1 ceg1 double mutant when overexpressed at the permissive temperature. YGL130W CEG1 11463793 ENSMUSP00000029942/PCE1 MUS_MUSCULUS/SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes This paper shows that a recombinant protein consisting of a truncated form of ENSMUSP00000029942 (MCE1 1-210) fused to S. pombe PCE1 can complement a yeast cet1 ceg1 double mutant. YPL228W CET1 11463793 ENSMUSP00000029942/PCE1 MUS_MUSCULUS/SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes This paper shows that a recombinant protein consisting of a truncated form of ENSMUSP00000029942 (MCE1 1-210) fused to S. pombe PCE1 can complement a yeast cet1 ceg1 double mutant. YGR181W TIM13 11489896 ENSP00000215570 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJR135W-A TIM8 11489896 ENSP00000247385 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOL133W HRT1 11500045 CG16982-PA DROSOPHILA_MELANOGASTER SACCHAROMYCES_CEREVISIAE yes YNL007C SIS1 11551903 TcJ6 TRYPANOSOMA_CRUZI SACCHAROMYCES_CEREVISIAE yes YLR192C HCR1 11560931 ENSP00000261868 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Hcr1p is a bifunctional protein in yeast. Human eIF3j (aka p35) complements the slow growth phenotype (i.e. the translation initiation defect) but not the 40S biogenesis defect of hcr1 mutant yeast. YGL253W HXK2 11571755 ENSP00000338009|ENSP00000223366|ENSP00000350996 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes All 3 human peptides map to the same GCK gene (ENSG00000106633). This paper shows that human GCK rescues a yeast hxk1 hxk2 glk1 triple mutant. YFR053C HXK1 11571755 ENSP00000338009|ENSP00000223366|ENSP00000350996 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes All 3 human peptides map to the same GCK gene (ENSG00000106633). This paper shows that human GCK rescues a yeast hxk1 hxk2 glk1 triple mutant. YCL040W GLK1 11571755 ENSP00000338009|ENSP00000223366|ENSP00000350996 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes All 3 human peptides map to the same GCK gene (ENSG00000106633). This paper shows that human GCK rescues a yeast hxk1 hxk2 glk1 triple mutant. YBR058C UBP14 11576424 AT3G20630.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YMR216C SKY1 11585720 ENSP00000339450|ENSP00000354674|ENSP00000246231 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YOL139C CDC33 11606200 ENSP00000280892 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJR074W MOG1 11686304 MOG1 SACCHAROMYCES_CEREVISIAE SCHIZOSACCHAROMYCES_POMBE yes YPL154C PEP4 11693924 PEP4 SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_KLUYVERI no expt YDR388W RVS167 11701884 AT1G31440.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt Complementation of the yeast rvs167 mutation by AtSH3P1 (AT1G31440.1; GenBank id: AF367773) suggested a functional role of AtSH3Ps in vesicle trafficking and actin organization in vivo. YDR388W RVS167 11701884 AT4G34660.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt Complementation of the yeast rvs167 mutation by AtSH3P2 (AT4G34660.1; GenBank id: AF367774) suggested a functional role of AtSH3Ps in vesicle trafficking and actin organization in vivo. YDR388W RVS167 11701884 AT4G18060.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no expt Complementation of the yeast rvs167 mutation by AtSH3P3 (AT4G18060.1; GenBank id: AF367775) suggested a functional role of AtSH3Ps in vesicle trafficking and actin organization in vivo. YML130C ERO1 11707280 ENSP00000352044|ENSP00000346447 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YJR017C ESS1 11707530 Pin1 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YIL035C CKA1 11725943 BvCKA2 BETA_VULGARIS SACCHAROMYCES_CEREVISIAE yes "Overexpression of B. vulgaris BvCKA2 can complement a yeast cka1 cka2 double mutant. According to the authors, yeast CKA1 and CKA2 are redundant genes encoding two related catalytic subunits." YOR061W CKA2 11725943 BvCKA2 BETA_VULGARIS SACCHAROMYCES_CEREVISIAE yes "Overexpression of B. vulgaris BvCKA2 can complement a yeast cka1 cka2 double mutant. According to the authors, yeast CKA1 and CKA2 are redundant genes encoding two related catalytic subunits." YDR062W LCB2 11726713 AT5G23670.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes AT5G23670.2 is a splice variant of A. thaliana LCB2 (AT5G23670.1). YEL027W CUP5 11733003 AACEVAPD2 ACETABULARIA_ACETABULUM SACCHAROMYCES_CEREVISIAE no expt This paper shows the heterologous expression of A. acetabulum AACEVAPD2 in a yeast cup5 null mutant in order to demonstrate that it encodes a functional proteolipid subunit of the V-ATPase complex. YEL027W CUP5 11733003 AACEVAPD4 ACETABULARIA_ACETABULUM SACCHAROMYCES_CEREVISIAE no expt This paper shows the heterologous expression of A. acetabulum AACEVAPD4 in a yeast cup5 null mutant in order to demonstrate that it encodes a functional proteolipid subunit of the V-ATPase complex. YEL027W CUP5 11733003 AACEVAPD5 ACETABULARIA_ACETABULUM SACCHAROMYCES_CEREVISIAE no expt This paper shows the heterologous expression of A. acetabulum AACEVAPD5 in a yeast cup5 null mutant in order to demonstrate that it encodes a functional proteolipid subunit of the V-ATPase complex. YEL027W CUP5 11733003 AACEVAPD6 ACETABULARIA_ACETABULUM SACCHAROMYCES_CEREVISIAE no expt This paper shows the heterologous expression of A. acetabulum AACEVAPD6 in a yeast cup5 null mutant in order to demonstrate that it encodes a functional proteolipid subunit of the V-ATPase complex. YOL006C TOP1 11733535 ENSP00000354522 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes Human Top1 restores camptothecin susceptibility to a yeast top1 mutant. YGL167C PMR1 11741891 ENSP00000306816|ENSP00000329664|ENSP00000352665 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes "All three peptides map to the same human gene ATP2C1 (ENSG00000017260). Human ATP2C1/hSPCA1 complements the yeast triple mutant (pmr1 pmc1 cnb1) deficient in the Golgi and vacuolar Ca(2+) pumps. In this study, ATP2C1/hSPCA1 also transports Ca2+ and Mn2+ with a high affinity similar to yeast PMR1 which was also re-introduced into the triple mutant in a separate ""complementation"" experiment. Human ATP2C1/hSPCA1 appears to be the functional homolog of yeast PMR1." YGL008C PMA1 11744700 AT4G30190.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "This paper shows that wild-type AHA2 does not complement a pma1 mutant, but mutants of AHA2 lacking the C-terminal domain or with key residues mutated do complement." YHR011W DIA4 11747308 SerZMm ZEA_MAYS SACCHAROMYCES_CEREVISIAE yes YGL087C MMS2 11752188 UEV STERKIELLA_HISTRIOMUSCORUM SACCHAROMYCES_CEREVISIAE yes YLR229C CDC42 11772396 CDC42 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YBL017C PEP1 11801606 PEP1/ENSG00000197081 SACCHAROMYCES_CEREVISIAE/HOMO_SAPIENS MUS_MUSCULUS no expt The chimeric construct contained the yeast PEP1 cytoplasmic domain in place of the human MPR300 (ENSG00000197081) cytoplasmic domain and it was expressed in mouse embryonic fibroblasts that lacked endogenous MPR46 and MPR300. YDL125C HNT1 11805111 Hint ORYCTOLAGUS_CUNICULUS SACCHAROMYCES_CEREVISIAE yes YML021C UNG1 11812822 ENSP00000242576|ENSP00000337398 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YNL216W RAP1 11816032 scasRAP1 SACCHAROMYCES_CASTELLII SACCHAROMYCES_CEREVISIAE yes S. castellii scasRAP1 is able to complement S. cerevisiae rap1 temperature-sensitive strains and is able to function as a regulator to maintain the original telomere lengths. YAL039C CYC3 11827457 ENSP00000326579 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YKL087C CYT2 11827457 ENSP00000326579 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no YBR109C CMD1 11855649 AT3G43810.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes A. thaliana AT3G43810.1 (CAM7) functionally complements yeast cmd1 to a greater extent than AT4G14640.1 and AT3G51920.1. YBR109C CMD1 11855649 AT4G14640.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "Although A. thaliana AT4G14640.1 (CAM8) can complement a yeast cmd1 mutant, AT3G43810.1 (CAM7) functionally complements yeast cmd1 to a greater extent." YBR109C CMD1 11855649 AT3G51920.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes "Although A. thaliana AT3G51920.1 (CAM9) can complement a yeast cmd1 mutant, AT3G43810.1 (CAM7) functionally complements yeast cmd1 to a greater extent." YDR400W URH1 11872485 ENSP00000330032 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper shows that human uridine phosphorylase (ENSP00000330032) rescues a yeast ura3 urk1 urh1 triple mutant. YNR012W URK1 11872485 ENSP00000330032 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper shows that human uridine phosphorylase (ENSP00000330032) rescues a yeast ura3 urk1 urh1 triple mutant. YEL021W URA3 11872485 ENSP00000330032 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE no expt This paper shows that human uridine phosphorylase (ENSP00000330032) rescues a yeast ura3 urk1 urh1 triple mutant. YDR400W URH1 11872485 Cf-IUNH CRITHIDIA_FASCICULATA SACCHAROMYCES_CEREVISIAE yes This paper shows that C. fasciculata Cf-IUNK is nucleoside hydrolase that can complement the growth defect on uridine caused by a urh1 mutation in a urk1 ura3 background. YPR005C HAL1 11910760 HAL1 SACCHAROMYCES_CEREVISIAE LYCOPERSICON_ESCULENTUM no expt This paper shows that the heterologous expression of yeast HAL1 in tomato plants improves their salt tolerance. The article is in Chinese and therefore the curation was based on the abstract alone. YER183C FAU1 11923304 FAU1 SACCHAROMYCES_CEREVISIAE ESCHERICHIA_COLI no expt YNR032C-A HUB1 11923536 ENSP00000351492 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YNR032C-A HUB1 11923536 ubl4 SCHIZOSACCHAROMYCES_POMBE SACCHAROMYCES_CEREVISIAE yes YLR186W EMG1 11935223 ENSP00000261406 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLR186W EMG1 11935223 CaNEP1 CANDIDA_ALBICANS SACCHAROMYCES_CEREVISIAE yes YLR186W EMG1 11935223 CgNEP1 CANDIDA_GLABRATA SACCHAROMYCES_CEREVISIAE yes YNL064C YDJ1 11939789 ENSP00000218763|ENSP00000353853|ENSP00000365991 HOMO_SAPIENS/SACCHAROMYCES_CEREVISIAE SACCHAROMYCES_CEREVISIAE yes A chimeric protein in which the human p58IPK J domain replaces the yeast Ydj1p J domain can complement a yeast ydj1 mutant. YBR109C CMD1 11950928 CMD1 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt YDR356W SPC110 11950928 SPC110 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt YHR172W SPC97 11950928 SPC97 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt YLR212C TUB4 11950928 TUB4 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt YNL126W SPC98 11950928 SPC98 SACCHAROMYCES_CEREVISIAE SPODOPTERA_FRUGIPERDA no expt YGR181W TIM13 11956200 ENSP00000215570 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YJR135W-A TIM8 11956200 ENSP00000247385 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YLL043W FPS1 11972053 AQP9 RATTUS_NORVEGICUS SACCHAROMYCES_CEREVISIAE yes YBR126C TPS1 11978181 SlTPS1 SELAGINELLA_LEPIDOPHYLLA SACCHAROMYCES_CEREVISIAE yes YBR126C TPS1 11978181 UNKNOWN:AtTPS1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YOR274W MOD5 11999372 AT2G27760.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE yes YGL115W SNF4 12008897 HSnIP1 ORDEUM_VULGARE SACCHAROMYCES_CEREVISIAE no YJR090C GRR1 12008900 AT4G03190.1 ARABIDOPSIS_THALIANA SACCHAROMYCES_CEREVISIAE no YGL236C MTO1 12011058 ENSP00000322398|ENSP00000322654|ENSP00000350506 HOMO_SAPIENS SACCHAROMYCES_CEREVISIAE yes YKL114C APN1 12032096 Nfo ESCHERICHIA_COLI SACCHAROMYCES_CEREVISIAE yes